ID   MRS2_MACFA              Reviewed;         408 AA.
AC   Q4R4M1;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Magnesium transporter MRS2 homolog, mitochondrial;
DE   AltName: Full=MRS2-like protein;
DE   Flags: Precursor;
GN   Name=MRS2; Synonyms=MRS2L; ORFNames=QflA-11728;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Frontal cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Magnesium transporter that mediates the influx of magnesium
CC       into the mitochondrial matrix. Required for normal expression of the
CC       mitochondrial respiratory complex I subunits.
CC       {ECO:0000250|UniProtKB:Q9HD23}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9HD23}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q9HD23}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC       family. {ECO:0000305}.
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DR   EMBL; AB169873; BAE01954.1; -; mRNA.
DR   AlphaFoldDB; Q4R4M1; -.
DR   SMR; Q4R4M1; -.
DR   STRING; 9541.XP_005553974.1; -.
DR   eggNOG; KOG2662; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0045016; P:mitochondrial magnesium ion transmembrane transport; ISS:UniProtKB.
DR   CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR   InterPro; IPR039204; MRS2-like.
DR   PANTHER; PTHR13890; PTHR13890; 1.
PE   2: Evidence at transcript level;
KW   Ion transport; Magnesium; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix; Transport.
FT   TRANSIT         1..62
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           63..408
FT                   /note="Magnesium transporter MRS2 homolog, mitochondrial"
FT                   /id="PRO_0000042838"
FT   TOPO_DOM        63..339
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        361..372
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        394..408
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   408 AA;  46385 MW;  551201F09C810A38 CRC64;
     MECLRSLPCL LPRAMRLPRR TLCALALDLT SVARPVAACG RAANLVGRSR AAQLCGPGRL
     RVAGEVHRLR TSDVSQATLA SVAPVFTVTK FDKQGNVTSF EKKKTELYQE LGLQARDLRF
     QHVMSITVRN NRIIMRMEYL KAVITPECLL ILDYRNLNLE QWLFRELPSQ LSGEGQLVTY
     PLPFEFRAIE ALLQYWINTL QGKLSILQPL ILETLDALVD PKHSSVDRSK LHILLQNGKS
     LSELETDIKI FKESILEILD EEELLEELCL SKWSDPQVFE KSSAGIDHAE EMELLLENYY
     RLADDLSNAA RELRVLIDDS QSIIFINLDS HRNVMMRLNL QLTMGTFSLS LFGLMGVAFG
     MNLESSLEED HRIFWLIIGI MFMGSGLIWR RLLSFLGRQL EAPLPPMV