ID   MP62_LYTPI              Reviewed;         411 AA.
AC   P91753;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Mitotic apparatus protein p62;
OS   Lytechinus pictus (Painted sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Temnopleuroida; Toxopneustidae; Lytechinus.
OX   NCBI_TaxID=7653;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9013612; DOI=10.1074/jbc.272.6.3606;
RA   Ye X., Sloboda R.D.;
RT   "Molecular characterization of p62, a mitotic apparatus protein required
RT   for mitotic progression.";
RL   J. Biol. Chem. 272:3606-3614(1997).
CC   -!- FUNCTION: Required for mitotic progression. Binds to chromatin.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- PTM: Phosphorylated by CaM-kinase II in vitro.
CC   -!- SIMILARITY: Belongs to the nucleoplasmin family. {ECO:0000305}.
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DR   EMBL; U76750; AAB47481.1; -; mRNA.
DR   AlphaFoldDB; P91753; -.
DR   SMR; P91753; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR032569; NPM1_C.
DR   InterPro; IPR004301; Nucleoplasmin.
DR   InterPro; IPR024057; Nucleoplasmin_core_dom.
DR   InterPro; IPR036824; Nucleoplasmin_core_dom_sf.
DR   PANTHER; PTHR22747; PTHR22747; 1.
DR   Pfam; PF16276; NPM1-C; 1.
DR   Pfam; PF03066; Nucleoplasmin; 1.
DR   SUPFAM; SSF69203; SSF69203; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Mitosis; Nucleus; Phosphoprotein.
FT   CHAIN           1..411
FT                   /note="Mitotic apparatus protein p62"
FT                   /id="PRO_0000219494"
FT   REGION          134..378
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..156
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        184..200
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        219..233
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        244..320
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        348..378
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   411 AA;  46386 MW;  D2DE04293C362254 CRC64;
     MAKEYFWGAT LSKDKKIFKW DPESDFLDDE DDDEEDSISH FLFLKQAVLG VNAKDDDRNV
     IEVETINFDG ETVIQPLLSL RLGLNESTNL DIGLQPPVTF KLALGSGPVY LSGQHALDLQ
     EDEEFGKDFE GAEAYEVGDE DLEDEDEGEE DEEEEETPKK GSPKRIVKKI AAVKGRMKGK
     GDELDEDEDD DEEEEEEEEE IQTAKGKKRP APSAKGPAKK LAKVDKDGTS KRKVPNGSVE
     NGHAIDDDED DEEDEDYKVG DEEEEEEATS GEEEEEDEEE EEEEDDEEMA LGDDDDEDDD
     EEDDEDEEGM DDEDEEEEED SSPVKPAKKA KGKVNGTAKP KGTPKSQANK GMKEKKTYSL
     EDMKQDLIKS PSKPKKEEKF KNFVKSKFHL SEGKKIQELW GWYKSTQLTA K