ID   MOS_CHICK               Reviewed;         349 AA.
AC   P10741;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Serine/threonine-protein kinase mos;
DE            EC=2.7.11.1;
DE   AltName: Full=Oocyte maturation factor mos;
GN   Name=MOS;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2832744; DOI=10.1128/mcb.8.2.923-929.1988;
RA   Schmidt M., Oskarsson M.K., Dunn J.K., Blair D.G., Hughes S., Propst F.,
RA   Vande Woude G.F.;
RT   "Chicken homolog of the mos proto-oncogene.";
RL   Mol. Cell. Biol. 8:923-929(1988).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1;
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC       kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR   EMBL; M19412; AAA48959.1; -; Genomic_DNA.
DR   PIR; A28130; TVCHMS.
DR   RefSeq; NP_001026687.1; NM_001031516.1.
DR   AlphaFoldDB; P10741; -.
DR   SMR; P10741; -.
DR   STRING; 9031.ENSGALP00000024805; -.
DR   PaxDb; P10741; -.
DR   Ensembl; ENSGALT00000063000; ENSGALP00000049891; ENSGALG00000042082.
DR   GeneID; 428537; -.
DR   KEGG; gga:428537; -.
DR   CTD; 4342; -.
DR   VEuPathDB; HostDB:geneid_428537; -.
DR   eggNOG; KOG0192; Eukaryota.
DR   GeneTree; ENSGT00940000160233; -.
DR   HOGENOM; CLU_000288_7_35_1; -.
DR   InParanoid; P10741; -.
DR   OMA; ITREQPY; -.
DR   OrthoDB; 993493at2759; -.
DR   PhylomeDB; P10741; -.
DR   BRENDA; 2.7.10.2; 1306.
DR   PRO; PR:P10741; -.
DR   Proteomes; UP000000539; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004709; F:MAP kinase kinase kinase activity; ISS:UniProtKB.
DR   GO; GO:0004672; F:protein kinase activity; IBA:GO_Central.
DR   GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR   GO; GO:0000165; P:MAPK cascade; ISS:UniProtKB.
DR   GO; GO:1902103; P:negative regulation of metaphase/anaphase transition of meiotic cell cycle; IBA:GO_Central.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; IBA:GO_Central.
DR   GO; GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase.
FT   CHAIN           1..349
FT                   /note="Serine/threonine-protein kinase mos"
FT                   /id="PRO_0000086351"
FT   DOMAIN          64..345
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   ACT_SITE        205
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT                   ECO:0000255|PROSITE-ProRule:PRU10027"
FT   BINDING         70..78
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         91
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ   SEQUENCE   349 AA;  38263 MW;  19182B0AC8934BF6 CRC64;
     MPSPIPFNSF LPLELSPSAD LRPCSSPVVI PGKDGKAFLG GTPSPRTRRL PPRLAWCSID
     WDRLCLLQPL GSGGFGAVYK ATYHGVTVAV KQVKKSSKNR LASRQSFWAE LNVARLQHDN
     VVRVVAASTC APASQNSLGT IIMEYVGNVT LHHVIYGTRD AWRQGEEEEG GCGRKALSMA
     EAVCYSCDIV TGLAFLHSQG IVHLDLKPAN ILITEHGACK IGDFGCSQRL EEGLSQSHHV
     CQQGGTYTHR APELLKGERV TAKADIYSFA ITLWQIVMRE QPYLGERQYV LYAVVAYNLR
     PPLAAAIFHE SAVGQRLRSI ISCCWKADVE ERLSAAQLLP SLRALKENL