ID   MORN_HYDVU              Reviewed;          11 AA.
AC   P69251; P01163;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 26.
DE   RecName: Full=Morphogenetic neuropeptide;
DE   AltName: Full=Head activator;
DE            Short=HA;
OS   Hydra vulgaris (Hydra) (Hydra attenuata).
OC   Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC   Aplanulata; Hydridae; Hydra.
OX   NCBI_TaxID=6087;
RN   [1]
RP   PROTEIN SEQUENCE, AND PYROGLUTAMATE FORMATION AT GLN-1.
RX   PubMed=16593123; DOI=10.1073/pnas.78.11.7000;
RA   Schaller H.C., Bodenmuller H.;
RT   "Isolation and amino acid sequence of a morphogenetic peptide from hydra.";
RL   Proc. Natl. Acad. Sci. U.S.A. 78:7000-7004(1981).
RN   [2]
RP   SYNTHESIS.
RX   PubMed=7297679; DOI=10.1016/0014-5793(81)80394-8;
RA   Birr C., Zachmann B., Bodenmuller H., Schaller H.C.;
RT   "Synthesis of a new neuropeptide, the head activator from hydra.";
RL   FEBS Lett. 131:317-321(1981).
CC   -!- FUNCTION: HA acts as an autocrine growth factor for neural cells in the
CC       G2/mitosis transition. {ECO:0000250}.
CC   -!- CAUTION: This peptide was first isolated from nerve cells of hydra and
CC       was called head activator by the authors, because it induced head-
CC       specific growth and differentiation in this animal. It has been found
CC       in mammalian intestine and hypothalamus. {ECO:0000305}.
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DR   PIR; B93900; YHJFHY.
DR   Proteomes; UP000694840; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; IPI:UniProtKB.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0048018; F:receptor ligand activity; IDA:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0002031; P:G protein-coupled receptor internalization; IDA:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IDA:UniProtKB.
DR   GO; GO:0090068; P:positive regulation of cell cycle process; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Direct protein sequencing; Growth factor;
KW   Mitosis; Pyrrolidone carboxylic acid; Reference proteome.
FT   PEPTIDE         1..11
FT                   /note="Morphogenetic neuropeptide"
FT                   /id="PRO_0000044168"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:16593123"
SQ   SEQUENCE   11 AA;  1142 MW;  37927417C325B878 CRC64;
     QPPGGSKVIL F