ID   MNS1_DANRE              Reviewed;         486 AA.
AC   Q6PBA8;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Meiosis-specific nuclear structural protein 1;
GN   Name=mns1; ORFNames=zgc:65845;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in the control of meiotic division and germ
CC       cell differentiation through regulation of pairing and recombination
CC       during meiosis (By similarity). Required for sperm flagella assembly
CC       (By similarity). May play a role in the assembly and function of the
CC       outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein
CC       arms (ODA) binding onto the axonemal doublet microtubules (By
CC       similarity). {ECO:0000250|UniProtKB:Q61884,
CC       ECO:0000250|UniProtKB:Q8NEH6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q61884}.
CC       Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q2KIQ2}.
CC       Cytoplasm, cytoskeleton, flagellum axoneme
CC       {ECO:0000250|UniProtKB:Q8NEH6}. Note=Microtubule inner protein (MIP)
CC       part of the dynein-decorated doublet microtubules (DMTs) in cilia
CC       axoneme. {ECO:0000250|UniProtKB:Q2KIQ2}.
CC   -!- SIMILARITY: Belongs to the MNS1 family. {ECO:0000305}.
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DR   EMBL; BC059798; AAH59798.1; -; mRNA.
DR   RefSeq; NP_955465.1; NM_199433.1.
DR   AlphaFoldDB; Q6PBA8; -.
DR   SMR; Q6PBA8; -.
DR   STRING; 7955.ENSDARP00000109926; -.
DR   PaxDb; Q6PBA8; -.
DR   PRIDE; Q6PBA8; -.
DR   GeneID; 573382; -.
DR   KEGG; dre:573382; -.
DR   CTD; 55329; -.
DR   ZFIN; ZDB-GENE-030521-42; mns1.
DR   eggNOG; ENOG502QS9D; Eukaryota.
DR   InParanoid; Q6PBA8; -.
DR   OrthoDB; 962490at2759; -.
DR   PhylomeDB; Q6PBA8; -.
DR   PRO; PR:Q6PBA8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; IDA:ZFIN.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0044782; P:cilium organization; IBA:GO_Central.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR026504; MNS1.
DR   InterPro; IPR043597; TPH_dom.
DR   PANTHER; PTHR19265; PTHR19265; 1.
DR   Pfam; PF13868; TPH; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum;
KW   Meiosis; Nucleus; Reference proteome.
FT   CHAIN           1..486
FT                   /note="Meiosis-specific nuclear structural protein 1"
FT                   /id="PRO_0000298925"
FT   COILED          52..198
FT                   /evidence="ECO:0000255"
FT   COILED          230..440
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   486 AA;  60446 MW;  EF61A10FE0777ABA CRC64;
     MILEHRKQEE RREDHSKRVV KERQLEANLS CEDRIERKRL LRKLQDEEYG KQIEESLLRA
     EEDKLFRERQ LEQEERMAKE LARINNEKLR DEKMRQYIKE NSVELRELEL KLKSAYLNRE
     RAAQMAEKEA MRYETLREEA MIARTMRDEH ELAEMEKEKL EQKKYEEVVR YQQELERQLE
     EKERKRQEAY EEFLKEKHMV DEIVRKIYME DQMELQLQLD KMKATQRYIE DFKKQQAEWR
     RMEREKVEAE NRRIIEFAQY QQRKEEDRMA KVREREQAKE TLHKMLSEQI ELEKQQREKM
     ERAREELCLE EQAEAARQQE IEEMEKRIRQ RLELQQTQQE MMAFKKLRLQ EEKEEEEAFR
     QMMMAKFAED DRIEQMNAQK RRMKQLEHKR AVEQLLEERR QQYLAEQERE EQERAVELER
     EAQRRKIIEE ERQRLLKQHA TKLLGYLPKG IFKEEDLEHF DEDFKSNFKQ RQADIFSDEG
     WGDDSQ