ID   ARMET_DROER             Reviewed;         173 AA.
AC   B3P113;
DT   19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Mesencephalic astrocyte-derived neurotrophic factor homolog;
DE   AltName: Full=MANF/CDNF-like protein;
DE   Flags: Precursor;
GN   Name=Manf {ECO:0000250|UniProtKB:Q9XZ63}; ORFNames=GG16999;
OS   Drosophila erecta (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7220;
RN   [1] {ECO:0000312|EMBL:EDV49132.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14021-0224.01 {ECO:0000312|EMBL:EDV49132.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required during the maturation of the embryonic nervous
CC       system for maintenance of neuronal and cuticular connectivity.
CC       Essential for maintenance of dopaminergic neurons and dopamine levels
CC       (By similarity). {ECO:0000250|UniProtKB:Q9XZ63}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9XZ63}.
CC   -!- SIMILARITY: Belongs to the ARMET family. {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH954181; EDV49132.1; -; Genomic_DNA.
DR   RefSeq; XP_001980174.1; XM_001980138.2.
DR   AlphaFoldDB; B3P113; -.
DR   SMR; B3P113; -.
DR   STRING; 7220.FBpp0135545; -.
DR   EnsemblMetazoa; FBtr0137053; FBpp0135545; FBgn0109227.
DR   GeneID; 6553590; -.
DR   KEGG; der:6553590; -.
DR   eggNOG; KOG4154; Eukaryota.
DR   HOGENOM; CLU_099080_1_0_1; -.
DR   OMA; ECEVCVS; -.
DR   OrthoDB; 1427430at2759; -.
DR   PhylomeDB; B3P113; -.
DR   ChiTaRS; Manf; fly.
DR   Proteomes; UP000008711; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblMetazoa.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0042417; P:dopamine metabolic process; IEA:EnsemblMetazoa.
DR   GO; GO:0070050; P:neuron cellular homeostasis; IEA:EnsemblMetazoa.
DR   GO; GO:0031175; P:neuron projection development; IEA:EnsemblMetazoa.
DR   GO; GO:0001963; P:synaptic transmission, dopaminergic; IEA:EnsemblMetazoa.
DR   Gene3D; 1.10.720.30; -; 1.
DR   InterPro; IPR045333; ARMET-like.
DR   InterPro; IPR019345; ARMET_C.
DR   InterPro; IPR045332; ARMET_N.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR036361; SAP_dom_sf.
DR   PANTHER; PTHR12990; PTHR12990; 1.
DR   Pfam; PF10208; ARMET_C; 1.
DR   Pfam; PF20145; ARMET_N; 1.
DR   SUPFAM; SSF68906; SSF68906; 1.
PE   3: Inferred from homology;
KW   Developmental protein; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..173
FT                   /note="Mesencephalic astrocyte-derived neurotrophic factor
FT                   homolog"
FT                   /id="PRO_0000390939"
FT   DISULFID        28..114
FT                   /evidence="ECO:0000250|UniProtKB:P55145"
FT   DISULFID        31..103
FT                   /evidence="ECO:0000250|UniProtKB:P55145"
FT   DISULFID        61..72
FT                   /evidence="ECO:0000250|UniProtKB:P55145"
FT   DISULFID        148..151
FT                   /evidence="ECO:0000250|UniProtKB:P55145"
SQ   SEQUENCE   173 AA;  20152 MW;  DB074C2BE3AAB4CF CRC64;
     MKTWYMVVVI GFLATLAQTS LALKEEDCEV CVKTVRRFAD SLDESTKKDY KQIETAFKKF
     CKTQKNKEHR FCYYLGGLEE SATGILNELS KPLSWSMPAE KVCEKLKKKD AQVCDLRYEK
     QIDLNSVDLK KLKVRDLKKI LNDWDESCDG CLEKGDFIKR IEELKPKYSR SEL