ARMC6_MOUSE
ID ARMC6_MOUSE Reviewed; 468 AA.
AC Q8BNU0; Q8C4P5; Q8C7S1; Q8K2S7; Q99JQ2; Q9CWE4;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Armadillo repeat-containing protein 6;
GN Name=Armc6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Brain cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Liver, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BNU0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BNU0-2; Sequence=VSP_019462, VSP_019463;
CC -!- PTM: Methylated at His-238 by METTL9. {ECO:0000250|UniProtKB:Q6NXE6}.
CC -!- SIMILARITY: Belongs to the ARMC6 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC38256.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK010815; BAB27199.1; -; mRNA.
DR EMBL; AK049351; BAC33700.1; -; mRNA.
DR EMBL; AK080609; BAC37956.1; -; mRNA.
DR EMBL; AK081550; BAC38256.1; ALT_FRAME; mRNA.
DR EMBL; BC005754; AAH05754.1; -; mRNA.
DR EMBL; BC030077; AAH30077.1; -; mRNA.
DR EMBL; BC043070; AAH43070.1; -; mRNA.
DR EMBL; BC055779; AAH55779.1; -; mRNA.
DR CCDS; CCDS40371.1; -. [Q8BNU0-1]
DR RefSeq; NP_598733.2; NM_133972.2. [Q8BNU0-1]
DR AlphaFoldDB; Q8BNU0; -.
DR SMR; Q8BNU0; -.
DR BioGRID; 218331; 1.
DR STRING; 10090.ENSMUSP00000019679; -.
DR PhosphoSitePlus; Q8BNU0; -.
DR EPD; Q8BNU0; -.
DR MaxQB; Q8BNU0; -.
DR PaxDb; Q8BNU0; -.
DR PeptideAtlas; Q8BNU0; -.
DR PRIDE; Q8BNU0; -.
DR ProteomicsDB; 283163; -. [Q8BNU0-1]
DR ProteomicsDB; 283164; -. [Q8BNU0-2]
DR Antibodypedia; 28329; 112 antibodies from 25 providers.
DR Ensembl; ENSMUST00000019679; ENSMUSP00000019679; ENSMUSG00000002343. [Q8BNU0-1]
DR GeneID; 76813; -.
DR KEGG; mmu:76813; -.
DR UCSC; uc009lzi.1; mouse. [Q8BNU0-1]
DR UCSC; uc009lzj.1; mouse. [Q8BNU0-2]
DR CTD; 93436; -.
DR MGI; MGI:1924063; Armc6.
DR VEuPathDB; HostDB:ENSMUSG00000002343; -.
DR eggNOG; KOG4199; Eukaryota.
DR GeneTree; ENSGT00390000002913; -.
DR HOGENOM; CLU_039447_1_0_1; -.
DR InParanoid; Q8BNU0; -.
DR OMA; QRNGAWA; -.
DR OrthoDB; 605325at2759; -.
DR PhylomeDB; Q8BNU0; -.
DR TreeFam; TF324526; -.
DR BioGRID-ORCS; 76813; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Armc6; mouse.
DR PRO; PR:Q8BNU0; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8BNU0; protein.
DR Bgee; ENSMUSG00000002343; Expressed in embryonic brain and 231 other tissues.
DR ExpressionAtlas; Q8BNU0; baseline and differential.
DR Genevisible; Q8BNU0; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IGI:MGI.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR040104; ARMC6.
DR PANTHER; PTHR22895:SF0; PTHR22895:SF0; 1.
DR Pfam; PF00514; Arm; 2.
DR SMART; SM00185; ARM; 6.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Methylation; Phosphoprotein; Reference proteome;
KW Repeat.
FT CHAIN 1..468
FT /note="Armadillo repeat-containing protein 6"
FT /id="PRO_0000242661"
FT REPEAT 195..239
FT /note="ARM 1"
FT REPEAT 249..293
FT /note="ARM 2"
FT REPEAT 294..336
FT /note="ARM 3"
FT REPEAT 337..379
FT /note="ARM 4"
FT MOD_RES 39
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6NXE6"
FT MOD_RES 238
FT /note="Pros-methylhistidine"
FT /evidence="ECO:0000250|UniProtKB:Q6NXE6"
FT VAR_SEQ 260..271
FT /note="AFSDNPGVLSEL -> GRSSPGKRMVGG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_019462"
FT VAR_SEQ 272..468
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_019463"
FT CONFLICT 277
FT /note="R -> L (in Ref. 1; BAC33700)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 468 AA; 50683 MW; 5FA79F94B2BDAF88 CRC64;
MASKRITQET FDAAVRENIE EFEMGTEEAI REAVEQFESQ GVDLSNIVKT IPKVSLDGLQ
EPTHSVLQAL NDLQESLTGS RLQEVSAHLV RFCDQCKQQK ASRYLAAQKG AYPILLAAWQ
LAATSNQGLL LQALNALAVL TDGQPDLLDA QGLHLLVATL AQNAANTELT CCGIRCVRHV
CLKHEQNRQD LVKAGVLPLL TAAITQHGQH ADVVREACWA LRVMTFDDDI RVPFGHAHEH
AKMIVQENKG LKVLIEAARA FSDNPGVLSE LCSTLSRLAV RNEFCQEVID LGGLGILVTL
LADCNDHQDL VKQVLSALRA IAGNDDVKDA IVRAGGTESI VAAMTRHLAS PQVCEQSCAA
LCVLALRKPD NSRVIIEGGG ALAALQAMKA HPQEAGVQKQ ACMLIRNLVS RSQVFSKPIL
DLGAEELILQ ARAAHPDCED VAKAALRDLG CRVELRELWT GKKGDLAL
