ID   MMPLA_MYCTO             Reviewed;        1002 AA.
AC   P9WJU0; L0T8N6; O50439; P65372;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Acyltrehalose exporter MmpL10 {ECO:0000250|UniProtKB:P9WJU1};
GN   Name=mmpL10; OrderedLocusNames=MT1220;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Required for the biosynthesis of polyacyltrehalose (PAT) and
CC       the transport of diacyltrehalose (DAT) and possibly PAT to the cell
CC       surface. {ECO:0000250|UniProtKB:P9WJU1}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P9WJU1}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000305}.
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DR   EMBL; AE000516; AAK45477.1; -; Genomic_DNA.
DR   PIR; G70876; G70876.
DR   RefSeq; WP_003898761.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJU0; -.
DR   EnsemblBacteria; AAK45477; AAK45477; MT1220.
DR   KEGG; mtc:MT1220; -.
DR   PATRIC; fig|83331.31.peg.1319; -.
DR   HOGENOM; CLU_005108_3_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR004707; MmpL_fam.
DR   Pfam; PF03176; MMPL; 2.
DR   TIGRFAMs; TIGR00833; actII; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Lipid transport; Membrane;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..1002
FT                   /note="Acyltrehalose exporter MmpL10"
FT                   /id="PRO_0000427771"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        306..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        806..826
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        835..855
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        862..882
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        901..921
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        923..943
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1002 AA;  106415 MW;  5B49B70AF2076AD8 CRC64;
     MVGCWVALAL VLPMAVPSLA EMAQRHPVAV LPADAPSSVA VRQMAEAFHE SGSENILVVL
     LTDEKGLGAA DENVYHTLVD RLRNDAKDVV MLQDFLTTPP LREVLGSKDG KAWILPIGLA
     GDLGTPKSYH AYTDVERIVK RTVAGTTLTA NVTGPAATVA DLTDAGARDR ASIELAIAVM
     LLVILMVIYR NPVTMLLPLV TIGASLMTAQ ALVAGVSLVG GLAVSNQAIV LLSAMIAGAG
     TDYAVFLISR YHEYVRLGEH PERAVQRAMM SVGKVIAASA ATVGITFLGM RFAKLGVFST
     VGPALAIGIA VSFLAAVTLL PAILVLASPR GWVAPRGERM ATFWRRAGTR IVRRPKAYLG
     ASLIGLVALA SCASLAHFNY DDRKQLPPSD PSSVGYAAME HHFSVNQTIP EYLIIHSAHD
     LRTPRGLADL EQLAQRVSQI PGVAMVRGVT RPNGETLEQA RATYQAGQVG NRLGGASRMI
     DERTGDLNRL ASGANLLADN LGDVRGQVSR AVAGVRSLVD ALAYIQNQFG GNKTFNEIDN
     AARLVSNIHA LGDALQVNFD GIANSFDWLD SVVAALDTSP VCDSNPMCGN ARVQFHKLQT
     ARDNGTLDKV VGLARQLQST RSPQTVSAVV NDLGRSLNSV VRSLKSLGLD NPDAARARLI
     SMQNGANDLA SAGRQVADGV QMLVDQTKNM GIGLNQASAF LMAMGNDASQ PSMAGFNVPP
     QVLKSEEFKK VAQAFISPDG HTVRYFIQTD LNPFSTAAMD QVNTIIDTAK GAQPNTSLAD
     ASISMSGYPV MLRDIRDYYE RDMRLIVAVT VVVVILILMA LLRAIVAPLY LVGSVVISYM
     SAIGLGVVVF QVFLGQELHW SVPGLAFVVL VAVGADYNML LASRLRDESA LGVRSSVIRT
     VRCTGGVITA AGLIFAASMS GLLFSSIGTV VQGGFIIGVG ILIDTFVVRT ITVPAMATLL
     GRASWWPGHP WQRCAPEEGQ MSARMSARTK TVFQAVADGS KR