ID   MLIC_YERE8              Reviewed;         117 AA.
AC   P28837; A1JNW5;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2016, sequence version 2.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Membrane-bound lysozyme inhibitor of C-type lysozyme {ECO:0000250|UniProtKB:P28224};
DE   Flags: Precursor;
GN   Name=mliC; OrderedLocusNames=YE2141 {ECO:0000312|EMBL:CAL12211.1};
OS   Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 /
OS   8081).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=393305;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 13174 / 8081;
RX   PubMed=17173484; DOI=10.1371/journal.pgen.0020206;
RA   Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L.,
RA   Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T.,
RA   Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S.,
RA   Sanders M., Whitehead S., Quail M.A., Dougan G., Parkhill J.,
RA   Prentice M.B.;
RT   "The complete genome sequence and comparative genome analysis of the high
RT   pathogenicity Yersinia enterocolitica strain 8081.";
RL   PLoS Genet. 2:2039-2051(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-101.
RC   STRAIN=ATCC 51872 / WA-C / Serotype O:8;
RA   Baeumler A.J.;
RL   Submitted (SEP-1991) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Specifically inhibits C-type lysozymes.
CC       {ECO:0000250|UniProtKB:P28224}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:P28224}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000250|UniProtKB:P28224}; Lipid-anchor {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}. Note=Anchored to the periplasmic side.
CC       {ECO:0000250|UniProtKB:P28224}.
CC   -!- SIMILARITY: Belongs to the MliC family. Type 1 subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM286415; CAL12211.1; -; Genomic_DNA.
DR   EMBL; X60449; CAA42979.1; -; Genomic_DNA.
DR   RefSeq; WP_011816373.1; NC_008800.1.
DR   RefSeq; YP_001006381.1; NC_008800.1.
DR   AlphaFoldDB; P28837; -.
DR   SMR; P28837; -.
DR   STRING; 393305.YE2141; -.
DR   EnsemblBacteria; CAL12211; CAL12211; YE2141.
DR   KEGG; yen:YE2141; -.
DR   PATRIC; fig|393305.7.peg.2304; -.
DR   eggNOG; COG3895; Bacteria.
DR   HOGENOM; CLU_166586_0_0_6; -.
DR   OMA; EYRCDEK; -.
DR   Proteomes; UP000000642; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.40.128.200; -; 1.
DR   InterPro; IPR018660; MliC.
DR   InterPro; IPR036328; MliC_sf.
DR   Pfam; PF09864; MliC; 1.
DR   SUPFAM; SSF141488; SSF141488; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Disulfide bond; Lipoprotein; Membrane; Palmitate;
KW   Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           22..117
FT                   /note="Membrane-bound lysozyme inhibitor of C-type
FT                   lysozyme"
FT                   /id="PRO_0000066375"
FT   SITE            70
FT                   /note="Directly involved in lysozyme active site
FT                   inhibition"
FT                   /evidence="ECO:0000250|UniProtKB:Q9I574"
FT   SITE            84
FT                   /note="Directly involved in lysozyme active site
FT                   inhibition"
FT                   /evidence="ECO:0000250|UniProtKB:Q9I574"
FT   LIPID           22
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           22
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   DISULFID        36..101
FT                   /evidence="ECO:0000250|UniProtKB:P28224"
SQ   SEQUENCE   117 AA;  12901 MW;  0CBF9472E4FFF9C4 CRC64;
     MKHLFGTTAV LGTAAVLMLT GCSLVQPKNE TLHYQCGGTK LTVMQDNKQD KVSLVLDGKQ
     LTLPQVRAAS GAKYSDNHYT FWSKGNTAFV ERDEKVIIND CRLLTTPNDS ILQGEDR