MLH3_HUMAN
ID MLH3_HUMAN Reviewed; 1453 AA.
AC Q9UHC1; P49751; Q56DK9; Q9P292; Q9UHC0;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 3.
DT 03-AUG-2022, entry version 186.
DE RecName: Full=DNA mismatch repair protein Mlh3;
DE AltName: Full=MutL protein homolog 3;
GN Name=MLH3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING, AND
RP VARIANTS ASP-826 AND LEU-844.
RX PubMed=10615123; DOI=10.1038/71643;
RA Lipkin S.M., Wang V., Jacoby R., Banerjee-Basu S., Baxevanis A.D.,
RA Lynch H.T., Elliott R.M., Collins F.S.;
RT "MLH3: a DNA mismatch repair gene associated with mammalian microsatellite
RT instability.";
RL Nat. Genet. 24:27-35(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH MLH1, AND VARIANT ASP-826.
RX PubMed=11292842; DOI=10.1093/nar/29.8.1695;
RA Kondo E., Horii A., Fukushige S.;
RT "The interacting domains of three MutL heterodimers in man: hMLH1 interacts
RT with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2.";
RL Nucleic Acids Res. 29:1695-1702(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLY-93; SER-120; GLN-231;
RP ILE-420; VAL-492; GLN-600; PRO-606; GLN-624; CYS-647; CYS-720; ILE-723;
RP PHE-741; HIS-797; ASP-826; LEU-844; GLY-845; ILE-942; PRO-966; ASN-1073;
RP GLU-1105; ASP-1163 AND ARG-1319.
RG NIEHS SNPs program;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1189-1453.
RC TISSUE=Brain;
RX PubMed=7596406; DOI=10.1038/375754a0;
RA Sherrington R., Rogaev E.I., Liang Y., Rogaeva E.A., Levesque G., Ikeda M.,
RA Chi H., Lin C., Li G., Holman K., Tsuda T., Mar L., Foncin J.-F.,
RA Bruni A.C., Montesi M.P., Sorbi S., Rainero I., Pinessi L., Nee L.,
RA Chumakov I., Pollen D., Brookes A., Sanseau P., Polinsky R.J., Wasco W.,
RA da Silva H.A.R., Haines J.L., Pericak-Vance M.A., Tanzi R.E., Roses A.D.,
RA Fraser P.E., Rommens J.M., St George-Hyslop P.H.;
RT "Cloning of a gene bearing missense mutations in early-onset familial
RT Alzheimer's disease.";
RL Nature 375:754-760(1995).
RN [6]
RP INVOLVEMENT IN SOMATIC COLORECTAL CANCER.
RX PubMed=11317354; DOI=10.1002/humu.1114;
RA Lipkin S.M., Wang V., Stoler D.L., Anderson G.R., Kirsch I., Hadley D.,
RA Lynch H.T., Collins F.S.;
RT "Germline and somatic mutation analyses in the DNA mismatch repair gene
RT MLH3: evidence for somatic mutation in colorectal cancers.";
RL Hum. Mutat. 17:389-396(2001).
RN [7]
RP INTERACTION WITH MTMR15.
RX PubMed=20603073; DOI=10.1016/j.molcel.2010.06.023;
RA Smogorzewska A., Desetty R., Saito T.T., Schlabach M., Lach F.P.,
RA Sowa M.E., Clark A.B., Kunkel T.A., Harper J.W., Colaiacovo M.P.,
RA Elledge S.J.;
RT "A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease
RT necessary for DNA interstrand crosslink repair.";
RL Mol. Cell 39:36-47(2010).
RN [8]
RP VARIANTS HNPCC7 GLU-24; SER-499; GLN-624; CYS-647; GLY-817; SER-981;
RP SER-1007; THR-1394 AND LYS-1451.
RX PubMed=11586295; DOI=10.1038/ng1001-137;
RA Wu Y., Berends M.J.W., Sijmons R.H., Mensink R.G.J., Verlind E., Kooi K.A.,
RA van der Sluis T., Kempinga C., van der Zee A.G.J., Hollema H.,
RA Buys C.H.C.M., Kleibeuker J.H., Hofstra R.M.W.;
RT "A role for MLH3 in hereditary nonpolyposis colorectal cancer.";
RL Nat. Genet. 29:137-138(2001).
CC -!- FUNCTION: Probably involved in the repair of mismatches in DNA.
CC -!- SUBUNIT: Heterodimer of MLH1 and MLH3. Interacts with MTMR15/FAN1.
CC {ECO:0000269|PubMed:11292842, ECO:0000269|PubMed:20603073}.
CC -!- INTERACTION:
CC Q9UHC1; P40692: MLH1; NbExp=4; IntAct=EBI-3893094, EBI-744248;
CC Q9UHC1-2; G5E9A7: DMWD; NbExp=3; IntAct=EBI-9089845, EBI-10976677;
CC Q9UHC1-2; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-9089845, EBI-5235340;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9UHC1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UHC1-2; Sequence=VSP_003290;
CC -!- TISSUE SPECIFICITY: Ubiquitous.
CC -!- DISEASE: Hereditary non-polyposis colorectal cancer 7 (HNPCC7)
CC [MIM:614385]: An autosomal dominant disease associated with marked
CC increase in cancer susceptibility. It is characterized by a familial
CC predisposition to early-onset colorectal carcinoma (CRC) and extra-
CC colonic tumors of the gastrointestinal, urological and female
CC reproductive tracts. HNPCC is reported to be the most common form of
CC inherited colorectal cancer in the Western world. Clinically, HNPCC is
CC often divided into two subgroups. Type I is characterized by hereditary
CC predisposition to colorectal cancer, a young age of onset, and
CC carcinoma observed in the proximal colon. Type II is characterized by
CC increased risk for cancers in certain tissues such as the uterus,
CC ovary, breast, stomach, small intestine, skin, and larynx in addition
CC to the colon. Diagnosis of classical HNPCC is based on the Amsterdam
CC criteria: 3 or more relatives affected by colorectal cancer, one a
CC first degree relative of the other two; 2 or more generation affected;
CC 1 or more colorectal cancers presenting before 50 years of age;
CC exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC'
CC or 'incomplete HNPCC' can be used to describe families who do not or
CC only partially fulfill the Amsterdam criteria, but in whom a genetic
CC basis for colon cancer is strongly suspected.
CC {ECO:0000269|PubMed:11586295}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- DISEASE: Colorectal cancer (CRC) [MIM:114500]: A complex disease
CC characterized by malignant lesions arising from the inner wall of the
CC large intestine (the colon) and the rectum. Genetic alterations are
CC often associated with progression from premalignant lesion (adenoma) to
CC invasive adenocarcinoma. Risk factors for cancer of the colon and
CC rectum include colon polyps, long-standing ulcerative colitis, and
CC genetic family history. {ECO:0000269|PubMed:11317354}. Note=The disease
CC is caused by variants affecting the gene represented in this entry.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC42005.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAC42005.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC URL="http://egp.gs.washington.edu/data/mlh3/";
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DR EMBL; AF195657; AAF23904.1; -; mRNA.
DR EMBL; AF195658; AAF23905.1; -; Genomic_DNA.
DR EMBL; AB039667; BAA92353.1; -; mRNA.
DR EMBL; AY963685; AAX59030.1; -; Genomic_DNA.
DR EMBL; AL049780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; L40399; AAC42005.1; ALT_SEQ; mRNA.
DR CCDS; CCDS32123.1; -. [Q9UHC1-1]
DR CCDS; CCDS9837.1; -. [Q9UHC1-2]
DR RefSeq; NP_001035197.1; NM_001040108.1. [Q9UHC1-1]
DR RefSeq; XP_006720179.1; XM_006720116.3. [Q9UHC1-1]
DR RefSeq; XP_016876708.1; XM_017021219.1. [Q9UHC1-2]
DR AlphaFoldDB; Q9UHC1; -.
DR SMR; Q9UHC1; -.
DR BioGRID; 117961; 55.
DR IntAct; Q9UHC1; 47.
DR MINT; Q9UHC1; -.
DR STRING; 9606.ENSP00000348020; -.
DR CarbonylDB; Q9UHC1; -.
DR iPTMnet; Q9UHC1; -.
DR PhosphoSitePlus; Q9UHC1; -.
DR BioMuta; MLH3; -.
DR DMDM; 317373417; -.
DR EPD; Q9UHC1; -.
DR jPOST; Q9UHC1; -.
DR MassIVE; Q9UHC1; -.
DR MaxQB; Q9UHC1; -.
DR PaxDb; Q9UHC1; -.
DR PeptideAtlas; Q9UHC1; -.
DR PRIDE; Q9UHC1; -.
DR ProteomicsDB; 84305; -. [Q9UHC1-1]
DR ProteomicsDB; 84306; -. [Q9UHC1-2]
DR Antibodypedia; 25763; 156 antibodies from 27 providers.
DR DNASU; 27030; -.
DR Ensembl; ENST00000355774.7; ENSP00000348020.2; ENSG00000119684.16. [Q9UHC1-1]
DR Ensembl; ENST00000380968.6; ENSP00000370355.3; ENSG00000119684.16. [Q9UHC1-2]
DR GeneID; 27030; -.
DR KEGG; hsa:27030; -.
DR MANE-Select; ENST00000355774.7; ENSP00000348020.2; NM_001040108.2; NP_001035197.1.
DR UCSC; uc001xrd.1; human. [Q9UHC1-1]
DR CTD; 27030; -.
DR DisGeNET; 27030; -.
DR GeneCards; MLH3; -.
DR HGNC; HGNC:7128; MLH3.
DR HPA; ENSG00000119684; Low tissue specificity.
DR MalaCards; MLH3; -.
DR MIM; 114500; phenotype.
DR MIM; 604395; gene.
DR MIM; 614385; phenotype.
DR neXtProt; NX_Q9UHC1; -.
DR OpenTargets; ENSG00000119684; -.
DR Orphanet; 144; Lynch syndrome.
DR PharmGKB; PA30845; -.
DR VEuPathDB; HostDB:ENSG00000119684; -.
DR eggNOG; KOG1977; Eukaryota.
DR GeneTree; ENSGT00800000124176; -.
DR HOGENOM; CLU_002376_0_0_1; -.
DR InParanoid; Q9UHC1; -.
DR OMA; MMSHFNE; -.
DR OrthoDB; 735423at2759; -.
DR PhylomeDB; Q9UHC1; -.
DR TreeFam; TF329597; -.
DR PathwayCommons; Q9UHC1; -.
DR Reactome; R-HSA-912446; Meiotic recombination.
DR SignaLink; Q9UHC1; -.
DR BioGRID-ORCS; 27030; 14 hits in 1082 CRISPR screens.
DR ChiTaRS; MLH3; human.
DR GeneWiki; MLH3; -.
DR GenomeRNAi; 27030; -.
DR Pharos; Q9UHC1; Tbio.
DR PRO; PR:Q9UHC1; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q9UHC1; protein.
DR Bgee; ENSG00000119684; Expressed in monocyte and 189 other tissues.
DR ExpressionAtlas; Q9UHC1; baseline and differential.
DR Genevisible; Q9UHC1; HS.
DR GO; GO:0005712; C:chiasma; IEA:Ensembl.
DR GO; GO:0001673; C:male germ cell nucleus; IEA:Ensembl.
DR GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; TAS:ProtInc.
DR GO; GO:0000795; C:synaptonemal complex; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0019237; F:centromeric DNA binding; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0003696; F:satellite DNA binding; TAS:ProtInc.
DR GO; GO:0007144; P:female meiosis I; IEA:Ensembl.
DR GO; GO:0007140; P:male meiotic nuclear division; IEA:Ensembl.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR GO; GO:0008104; P:protein localization; IEA:Ensembl.
DR GO; GO:0007131; P:reciprocal meiotic recombination; NAS:UniProtKB.
DR GO; GO:0007130; P:synaptonemal complex assembly; IEA:Ensembl.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR028830; Mlh3.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 1.
DR PANTHER; PTHR10073:SF47; PTHR10073:SF47; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Disease variant; DNA damage; DNA repair;
KW Hereditary nonpolyposis colorectal cancer; Nucleus; Reference proteome.
FT CHAIN 1..1453
FT /note="DNA mismatch repair protein Mlh3"
FT /id="PRO_0000178003"
FT REGION 624..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 933..960
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1215..1238
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_003290"
FT VARIANT 24
FT /note="Q -> E (in HNPCC7; dbSNP:rs28937870)"
FT /evidence="ECO:0000269|PubMed:11586295"
FT /id="VAR_012946"
FT VARIANT 93
FT /note="R -> G (in dbSNP:rs28756978)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_023338"
FT VARIANT 120
FT /note="F -> S (in dbSNP:rs28756979)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_023339"
FT VARIANT 231
FT /note="K -> Q (in dbSNP:rs28756981)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_023340"
FT VARIANT 420
FT /note="V -> I (in dbSNP:rs28756982)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_023341"
FT VARIANT 492
FT /note="L -> V (in dbSNP:rs28756983)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_023342"
FT VARIANT 494
FT /note="H -> R (in dbSNP:rs760778201)"
FT /id="VAR_010790"
FT VARIANT 499
FT /note="N -> S (in HNPCC7; dbSNP:rs28937871)"
FT /evidence="ECO:0000269|PubMed:11586295"
FT /id="VAR_012947"
FT VARIANT 600
FT /note="R -> Q (in dbSNP:rs28756984)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_023343"
FT VARIANT 606
FT /note="T -> P (in dbSNP:rs28756985)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_023344"
FT VARIANT 624
FT /note="E -> Q (in HNPCC7; dbSNP:rs28756986)"
FT /evidence="ECO:0000269|PubMed:11586295, ECO:0000269|Ref.3"
FT /id="VAR_012948"
FT VARIANT 647
FT /note="R -> C (in HNPCC7; dbSNP:rs28756987)"
FT /evidence="ECO:0000269|PubMed:11586295, ECO:0000269|Ref.3"
FT /id="VAR_012949"
FT VARIANT 720
FT /note="Y -> C (in dbSNP:rs28756988)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_023345"
FT VARIANT 723
FT /note="V -> I (in dbSNP:rs28756989)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_023346"
FT VARIANT 741
FT /note="V -> F (in dbSNP:rs28756990)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_023347"
FT VARIANT 797
FT /note="R -> H (in dbSNP:rs28756991)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_023348"
FT VARIANT 817
FT /note="S -> G (in HNPCC7; dbSNP:rs143278116)"
FT /evidence="ECO:0000269|PubMed:11586295"
FT /id="VAR_012950"
FT VARIANT 826
FT /note="N -> D (in dbSNP:rs175081)"
FT /evidence="ECO:0000269|PubMed:10615123,
FT ECO:0000269|PubMed:11292842, ECO:0000269|Ref.3"
FT /id="VAR_036781"
FT VARIANT 844
FT /note="P -> L (in dbSNP:rs175080)"
FT /evidence="ECO:0000269|PubMed:10615123, ECO:0000269|Ref.3"
FT /id="VAR_023349"
FT VARIANT 845
FT /note="S -> G (in dbSNP:rs28756992)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_023350"
FT VARIANT 942
FT /note="T -> I (in dbSNP:rs17102999)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_023351"
FT VARIANT 966
FT /note="S -> P (in dbSNP:rs17782839)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_023352"
FT VARIANT 981
FT /note="G -> S (in HNPCC7; dbSNP:rs377337763)"
FT /evidence="ECO:0000269|PubMed:11586295"
FT /id="VAR_012951"
FT VARIANT 1007
FT /note="N -> S (in HNPCC7; dbSNP:rs776639203)"
FT /evidence="ECO:0000269|PubMed:11586295"
FT /id="VAR_012952"
FT VARIANT 1073
FT /note="D -> N (in dbSNP:rs28756993)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_023353"
FT VARIANT 1105
FT /note="D -> E (in dbSNP:rs28757008)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_023354"
FT VARIANT 1163
FT /note="G -> D (in dbSNP:rs28757011)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_023355"
FT VARIANT 1319
FT /note="G -> R"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_023356"
FT VARIANT 1394
FT /note="A -> T (in HNPCC7; dbSNP:rs138006166)"
FT /evidence="ECO:0000269|PubMed:11586295"
FT /id="VAR_012953"
FT VARIANT 1451
FT /note="E -> K (in HNPCC7; dbSNP:rs28939071)"
FT /evidence="ECO:0000269|PubMed:11586295"
FT /id="VAR_012954"
SQ SEQUENCE 1453 AA; 163711 MW; 3D063427457DB033 CRC64;
MIKCLSVEVQ AKLRSGLAIS SLGQCVEELA LNSIDAEAKC VAVRVNMETF QVQVIDNGFG
MGSDDVEKVG NRYFTSKCHS VQDLENPRFY GFRGEALANI ADMASAVEIS SKKNRTMKTF
VKLFQSGKAL KACEADVTRA SAGTTVTVYN LFYQLPVRRK CMDPRLEFEK VRQRIEALSL
MHPSISFSLR NDVSGSMVLQ LPKTKDVCSR FCQIYGLGKS QKLREISFKY KEFELSGYIS
SEAHYNKNMQ FLFVNKRLVL RTKLHKLIDF LLRKESIICK PKNGPTSRQM NSSLRHRSTP
ELYGIYVINV QCQFCEYDVC MEPAKTLIEF QNWDTLLFCI QEGVKMFLKQ EKLFVELSGE
DIKEFSEDNG FSLFDATLQK RVTSDERSNF QEACNNILDS YEMFNLQSKA VKRKTTAENV
NTQSSRDSEA TRKNTNDAFL YIYESGGPGH SKMTEPSLQN KDSSCSESKM LEQETIVASE
AGENEKHKKS FLEHSSLENP CGTSLEMFLS PFQTPCHFEE SGQDLEIWKE STTVNGMAAN
ILKNNRIQNQ PKRFKDATEV GCQPLPFATT LWGVHSAQTE KEKKKESSNC GRRNVFSYGR
VKLCSTGFIT HVVQNEKTKS TETEHSFKNY VRPGPTRAQE TFGNRTRHSV ETPDIKDLAS
TLSKESGQLP NKKNCRTNIS YGLENEPTAT YTMFSAFQEG SKKSQTDCIL SDTSPSFPWY
RHVSNDSRKT DKLIGFSKPI VRKKLSLSSQ LGSLEKFKRQ YGKVENPLDT EVEESNGVTT
NLSLQVEPDI LLKDKNRLEN SDVCKITTME HSDSDSSCQP ASHILNSEKF PFSKDEDCLE
QQMPSLRESP MTLKELSLFN RKPLDLEKSS ESLASKLSRL KGSERETQTM GMMSRFNELP
NSDSSRKDSK LCSVLTQDFC MLFNNKHEKT ENGVIPTSDS ATQDNSFNKN SKTHSNSNTT
ENCVISETPL VLPYNNSKVT GKDSDVLIRA SEQQIGSLDS PSGMLMNPVE DATGDQNGIC
FQSEESKARA CSETEESNTC CSDWQRHFDV ALGRMVYVNK MTGLSTFIAP TEDIQAACTK
DLTTVAVDVV LENGSQYRCQ PFRSDLVLPF LPRARAERTV MRQDNRDTVD DTVSSESLQS
LFSEWDNPVF ARYPEVAVDV SSGQAESLAV KIHNILYPYR FTKGMIHSMQ VLQQVDNKFI
ACLMSTKTEE NGEAGGNLLV LVDQHAAHER IRLEQLIIDS YEKQQAQGSG RKKLLSSTLI
PPLEITVTEE QRRLLWCYHK NLEDLGLEFV FPDTSDSLVL VGKVPLCFVE REANELRRGR
STVTKSIVEE FIREQLELLQ TTGGIQGTLP LTVQKVLASQ ACHGAIKFND GLSLQESCRL
IEALSSCQLP FQCAHGRPSM LPLADIDHLE QEKQIKPNLT KLRKMAQAWR LFGKAECDTR
QSLQQSMPPC EPP
