ID   MLH1_SCHPO              Reviewed;         684 AA.
AC   Q9P7W6; P78862;
DT   29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=Putative MutL protein homolog 1;
DE   AltName: Full=DNA mismatch repair protein MLH1;
GN   Name=mlh1; ORFNames=SPBC1703.04;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 305-684.
RC   STRAIN=PR745;
RX   PubMed=9501991; DOI=10.1093/dnares/4.6.363;
RA   Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.;
RT   "Identification of open reading frames in Schizosaccharomyces pombe
RT   cDNAs.";
RL   DNA Res. 4:363-369(1997).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA13873.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; CU329671; CAB66448.1; -; Genomic_DNA.
DR   EMBL; D89212; BAA13873.1; ALT_FRAME; mRNA.
DR   PIR; T43016; T43016.
DR   PIR; T50317; T50317.
DR   RefSeq; NP_596199.1; NM_001022118.2.
DR   AlphaFoldDB; Q9P7W6; -.
DR   SMR; Q9P7W6; -.
DR   BioGRID; 276493; 43.
DR   STRING; 4896.SPBC1703.04.1; -.
DR   MaxQB; Q9P7W6; -.
DR   PaxDb; Q9P7W6; -.
DR   PRIDE; Q9P7W6; -.
DR   EnsemblFungi; SPBC1703.04.1; SPBC1703.04.1:pep; SPBC1703.04.
DR   GeneID; 2539949; -.
DR   KEGG; spo:SPBC1703.04; -.
DR   PomBase; SPBC1703.04; mlh1.
DR   VEuPathDB; FungiDB:SPBC1703.04; -.
DR   eggNOG; KOG1979; Eukaryota.
DR   HOGENOM; CLU_004131_2_0_1; -.
DR   InParanoid; Q9P7W6; -.
DR   OMA; ANYHVKK; -.
DR   PhylomeDB; Q9P7W6; -.
DR   Reactome; R-SPO-5358565; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).
DR   PRO; PR:Q9P7W6; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR   GO; GO:0044732; C:mitotic spindle pole body; HDA:PomBase.
DR   GO; GO:0032389; C:MutLalpha complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR032189; Mlh1_C.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF16413; Mlh1_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   2: Evidence at transcript level;
KW   DNA damage; DNA repair; Nucleus; Reference proteome.
FT   CHAIN           1..684
FT                   /note="Putative MutL protein homolog 1"
FT                   /id="PRO_0000178007"
SQ   SEQUENCE   684 AA;  77254 MW;  7A59633B38E2944B CRC64;
     MDVNSRAKIR PLDQLVINKI AAGEIIERPE NAIKELIENS LDAGSTSIDV LLKDGGLKLL
     QITDNGSGIQ YDDLPYLCQR FSTSKIDNFN DLQHLQTFGF RGEALASISH VAKVTVVTKL
     SSDIHAWKAF YVDGALAPIS PGMSPAPQPC AGKQGTVITA EDLFYNVRSR KSALKNGSEE
     FRRIMILVQK YAIHNDQVSF NCKKVGDTVA SLSLSSRLSK ADKIRHIYGP RVASHLRDFS
     LGEGQSSIVG FSANGFISNA DFQDKKSNLI LFINNRLVES VELRHALEET YAKYLHKGAS
     YFVYLSLNMS PEQLDVNVHP SKRIVHFLYD QEIATSICDK LGEILERTDT ERSYPLQAMI
     PSISNTKNAE SSSQKAVRTY ENYLVRTDPR ERSIKSMLSD NFLQRSSNNY DNEIIEKVDS
     ANSNKNATND IKDLQTEEIV EEGNSIDLES IKSLQKQVIN SMHVLATNIL TEHKYVGLVC
     PTRRIAAVQH NIGLYVVDYG KLSYHLFYQI CLTEFGNYGE FVLETPLSIS DLFEIVNGDE
     DKSESEKFTR LLVSRRDMLK DYFSISVTSG GLLTAVPMLS PKYHPPFEQL PLLISSLTPK
     FFDWLDEKSC LNGIMKAIAK FYVPLPLSYE ESDVKSIRSL ESCLEDYLFP EFRRRVICPK
     KVFEEKCIYQ ITSLPRLYNV FERC