ID   MLF2_MOUSE              Reviewed;         247 AA.
AC   Q99KX1;
DT   02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Myeloid leukemia factor 2;
DE   AltName: Full=Myelodysplasia-myeloid leukemia factor 2;
GN   Name=Mlf2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=16452087; DOI=10.1074/mcp.t500041-mcp200;
RA   Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT   "Comprehensive identification of phosphorylation sites in postsynaptic
RT   density preparations.";
RL   Mol. Cell. Proteomics 5:914-922(2006).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Lung, Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MLF family. {ECO:0000305}.
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DR   EMBL; BC003975; AAH03975.1; -; mRNA.
DR   CCDS; CCDS20538.1; -.
DR   RefSeq; NP_001163812.1; NM_001170341.1.
DR   RefSeq; NP_663360.1; NM_145385.2.
DR   AlphaFoldDB; Q99KX1; -.
DR   SMR; Q99KX1; -.
DR   BioGRID; 205980; 9.
DR   IntAct; Q99KX1; 4.
DR   MINT; Q99KX1; -.
DR   STRING; 10090.ENSMUSP00000032214; -.
DR   iPTMnet; Q99KX1; -.
DR   PhosphoSitePlus; Q99KX1; -.
DR   EPD; Q99KX1; -.
DR   jPOST; Q99KX1; -.
DR   MaxQB; Q99KX1; -.
DR   PaxDb; Q99KX1; -.
DR   PRIDE; Q99KX1; -.
DR   ProteomicsDB; 290085; -.
DR   Antibodypedia; 2268; 250 antibodies from 28 providers.
DR   DNASU; 30853; -.
DR   Ensembl; ENSMUST00000032214; ENSMUSP00000032214; ENSMUSG00000030120.
DR   Ensembl; ENSMUST00000180095; ENSMUSP00000135920; ENSMUSG00000030120.
DR   GeneID; 30853; -.
DR   KEGG; mmu:30853; -.
DR   UCSC; uc009dso.2; mouse.
DR   CTD; 8079; -.
DR   MGI; MGI:1353554; Mlf2.
DR   VEuPathDB; HostDB:ENSMUSG00000030120; -.
DR   eggNOG; KOG4049; Eukaryota.
DR   GeneTree; ENSGT00390000005023; -.
DR   HOGENOM; CLU_063313_3_0_1; -.
DR   InParanoid; Q99KX1; -.
DR   OMA; DDPFMMD; -.
DR   OrthoDB; 1471165at2759; -.
DR   PhylomeDB; Q99KX1; -.
DR   TreeFam; TF317561; -.
DR   BioGRID-ORCS; 30853; 0 hits in 71 CRISPR screens.
DR   ChiTaRS; Mlf2; mouse.
DR   PRO; PR:Q99KX1; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; Q99KX1; protein.
DR   Bgee; ENSMUSG00000030120; Expressed in embryonic brain and 252 other tissues.
DR   ExpressionAtlas; Q99KX1; baseline and differential.
DR   Genevisible; Q99KX1; MM.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR019376; Myeloid_leukemia_factor.
DR   PANTHER; PTHR13105; PTHR13105; 1.
DR   Pfam; PF10248; Mlf1IP; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..247
FT                   /note="Myeloid leukemia factor 2"
FT                   /id="PRO_0000220755"
FT   REGION          122..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        151..219
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         216
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15773"
FT   MOD_RES         237
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         239
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15773"
SQ   SEQUENCE   247 AA;  28055 MW;  00097529ECAB0123 CRC64;
     MFRFMRDVEP EDPMFLMDPF AIHRQHMSRM LSGGFGYSPF LSITDGNMPA TRPASRRMQA
     GAVSPFGMLG MSGGFMDMFG MMNDMIGNME HMAAGGNCQT FSSSTVISYS NTGDGAPKVY
     QETSEMRSAP GGIRETRRTV RDSDSGLEQM SIGHHIRDRA HILQRSRNHR TGDQEERQDY
     INLDESEAAA FDDEWRRETS RYRQQRPLEF RRHEASVGGG RRAEGPPRLA IQGPEDSPSR
     QSRRYDW