ID   MEST_RAT                Reviewed;         335 AA.
AC   Q6P5P5;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Mesoderm-specific transcript homolog protein;
DE            EC=3.-.-.-;
GN   Name=Mest;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. {ECO:0000305}.
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DR   EMBL; BC062800; AAH62800.1; -; mRNA.
DR   RefSeq; NP_001009617.1; NM_001009617.1.
DR   AlphaFoldDB; Q6P5P5; -.
DR   SMR; Q6P5P5; -.
DR   IntAct; Q6P5P5; 1.
DR   MINT; Q6P5P5; -.
DR   STRING; 10116.ENSRNOP00000065620; -.
DR   ESTHER; ratno-q6p5p5; MEST-like.
DR   GlyGen; Q6P5P5; 1 site.
DR   jPOST; Q6P5P5; -.
DR   PaxDb; Q6P5P5; -.
DR   PRIDE; Q6P5P5; -.
DR   Ensembl; ENSRNOT00000072698; ENSRNOP00000065620; ENSRNOG00000048088.
DR   GeneID; 58827; -.
DR   KEGG; rno:58827; -.
DR   CTD; 4232; -.
DR   RGD; 1594589; Mest.
DR   eggNOG; KOG4178; Eukaryota.
DR   GeneTree; ENSGT00510000047602; -.
DR   InParanoid; Q6P5P5; -.
DR   OrthoDB; 1268438at2759; -.
DR   PhylomeDB; Q6P5P5; -.
DR   PRO; PR:Q6P5P5; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0010883; P:regulation of lipid storage; ISO:RGD.
DR   GO; GO:0032526; P:response to retinoic acid; ISO:RGD.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR000639; Epox_hydrolase-like.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   PRINTS; PR00412; EPOXHYDRLASE.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Glycoprotein; Hydrolase; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..335
FT                   /note="Mesoderm-specific transcript homolog protein"
FT                   /id="PRO_0000284420"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        266..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          71..310
FT                   /note="AB hydrolase-1"
FT                   /evidence="ECO:0000255"
FT   MOTIF           98..103
FT                   /note="RVIALD"
FT   CARBOHYD        163
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   335 AA;  38879 MW;  00EC814F7BE34B14 CRC64;
     MVRRDRLRRM REWWVQVGLL AVPLLAAYLH IPPPQLSPAL HSWKTSGKFF TYKGLRIFYQ
     DSVGVVGSPE IVVLLHGFPT SSYDWYKIWE GLTLRFHRVI ALDFLGFGFS DKPRPHQYSI
     FEQASIVESL LRHLGLQNRR INLLSHDYGD IVAQELLYRY KQNRSGRLTI KSLCLSNGGI
     FPETHRPLLL QKLLKDGGVL SPILTRLMNF FVFSRGLTPV FGPYTRPTES ELWDMWAGIR
     NNDGNLVIDS LLQYINQRKK FRRRWVGALA SVTIPIHFIY GPLDPINPYP EFLELYRKTL
     PRSTVSILDD HISHYPQLED PMGFLNAYMG FINSF