ID   MED7_DANRE              Reviewed;         241 AA.
AC   Q7ZV35;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 7;
DE   AltName: Full=Cofactor required for Sp1 transcriptional activation subunit 9;
DE            Short=CRSP complex subunit 9;
DE   AltName: Full=Mediator complex subunit 7;
GN   Name=med7; Synonyms=crsp9;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=SJD;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 7 family.
CC       {ECO:0000305}.
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DR   EMBL; BC046018; AAH46018.1; -; mRNA.
DR   RefSeq; NP_956035.1; NM_199741.1.
DR   AlphaFoldDB; Q7ZV35; -.
DR   SMR; Q7ZV35; -.
DR   STRING; 7955.ENSDARP00000010075; -.
DR   PaxDb; Q7ZV35; -.
DR   GeneID; 326098; -.
DR   KEGG; dre:326098; -.
DR   CTD; 9443; -.
DR   ZFIN; ZDB-GENE-030131-4823; med7.
DR   eggNOG; KOG0570; Eukaryota.
DR   InParanoid; Q7ZV35; -.
DR   OrthoDB; 1356482at2759; -.
DR   PhylomeDB; Q7ZV35; -.
DR   Reactome; R-DRE-212436; Generic Transcription Pathway.
DR   PRO; PR:Q7ZV35; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 6.10.140.200; -; 1.
DR   InterPro; IPR037212; Med7/Med21-like.
DR   InterPro; IPR009244; Mediatior_Med7.
DR   InterPro; IPR044888; Mediatior_Med7_sf.
DR   Pfam; PF05983; Med7; 1.
DR   SUPFAM; SSF140718; SSF140718; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..241
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   7"
FT                   /id="PRO_0000303181"
FT   REGION          175..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   241 AA;  27519 MW;  541808899FBE27E6 CRC64;
     MGEPQQVSAL PPPPMQYIKE YTDENVRKGL APKPPPPIRD SYMMFGNQFQ CDDLIIRPLE
     SQGIERLHPM QFDHKRELKK LNMSILVNFL DLLDILIKSP GSIKREEKLE DLKLLFVHMH
     HLINEYRPHQ ARETLRVMME VQKRQRLETA ERFQKHLERV VEMIQGCLSS LPDDLPLPNS
     SSMGEAGSAA GSSRLKTEPM DVDDVAGASC MVLQTDKNVP VKKDGVCDND VVMCRIIDEM
     T