ID   MECR_STAAU              Reviewed;         585 AA.
AC   P0A0B1; P26597; P72353;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Methicillin resistance mecR1 protein;
GN   Name=mecR1; Synonyms=mecR;
OS   Staphylococcus aureus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BMS-1;
RX   PubMed=7911288; DOI=10.1128/aac.38.3.447;
RA   Archer G.L., Niemeyer D.M., Thanassi J.A., Pucci M.J.;
RT   "Dissemination among staphylococci of DNA sequences associated with
RT   methicillin resistance.";
RL   Antimicrob. Agents Chemother. 38:447-454(1994).
CC   -!- FUNCTION: Penicillin-interactive protein and potential antirepressor.
CC   -!- SIMILARITY: Belongs to the peptidase M56 family. {ECO:0000305}.
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DR   EMBL; L14020; AAA21182.1; -; Genomic_DNA.
DR   PIR; S20575; S20575.
DR   RefSeq; WP_000952923.1; NZ_WBTW01000007.1.
DR   PDB; 6O9S; X-ray; 1.59 A; A=334-585.
DR   PDBsum; 6O9S; -.
DR   AlphaFoldDB; P0A0B1; -.
DR   SMR; P0A0B1; -.
DR   ChEMBL; CHEMBL3706557; -.
DR   MEROPS; M56.002; -.
DR   OMA; VNGWFIG; -.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.710.10; -; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   InterPro; IPR008756; Peptidase_M56.
DR   Pfam; PF05569; Peptidase_M56; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; SSF56601; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Antibiotic resistance.
FT   CHAIN           1..585
FT                   /note="Methicillin resistance mecR1 protein"
FT                   /id="PRO_0000096351"
FT   REGION          351..585
FT                   /note="Beta-lactamase-like"
FT   STRAND          348..350
FT                   /evidence="ECO:0007829|PDB:6O9S"
FT   HELIX           352..358
FT                   /evidence="ECO:0007829|PDB:6O9S"
FT   STRAND          361..369
FT                   /evidence="ECO:0007829|PDB:6O9S"
FT   TURN            370..373
FT                   /evidence="ECO:0007829|PDB:6O9S"
FT   STRAND          374..378
FT                   /evidence="ECO:0007829|PDB:6O9S"
FT   HELIX           380..384
FT                   /evidence="ECO:0007829|PDB:6O9S"
FT   HELIX           390..393
FT                   /evidence="ECO:0007829|PDB:6O9S"
FT   HELIX           394..403
FT                   /evidence="ECO:0007829|PDB:6O9S"
FT   STRAND          406..408
FT                   /evidence="ECO:0007829|PDB:6O9S"
FT   HELIX           424..426
FT                   /evidence="ECO:0007829|PDB:6O9S"
FT   HELIX           432..437
FT                   /evidence="ECO:0007829|PDB:6O9S"
FT   HELIX           441..449
FT                   /evidence="ECO:0007829|PDB:6O9S"
FT   HELIX           453..463
FT                   /evidence="ECO:0007829|PDB:6O9S"
FT   TURN            474..477
FT                   /evidence="ECO:0007829|PDB:6O9S"
FT   STRAND          478..481
FT                   /evidence="ECO:0007829|PDB:6O9S"
FT   HELIX           486..497
FT                   /evidence="ECO:0007829|PDB:6O9S"
FT   STRAND          501..503
FT                   /evidence="ECO:0007829|PDB:6O9S"
FT   HELIX           505..514
FT                   /evidence="ECO:0007829|PDB:6O9S"
FT   STRAND          516..519
FT                   /evidence="ECO:0007829|PDB:6O9S"
FT   STRAND          521..534
FT                   /evidence="ECO:0007829|PDB:6O9S"
FT   STRAND          537..551
FT                   /evidence="ECO:0007829|PDB:6O9S"
FT   STRAND          553..561
FT                   /evidence="ECO:0007829|PDB:6O9S"
FT   HELIX           568..581
FT                   /evidence="ECO:0007829|PDB:6O9S"
SQ   SEQUENCE   585 AA;  68503 MW;  D3E1075FC9AD57C0 CRC64;
     MLSSFLMLSI ISSLLTICVI FLVRMLYIKY TQNIMSHKIW LLVLVSTLIP LIPFYKISNF
     TFSKDMMNRN VSDTTSSVSH MLDGQQSSVT KDLAINVNQF ETSNITYMIL LIWVFGSLLC
     LFYMIKAFRQ IDVIKSSSLE SSYLNERLKV CQSKMQFYKK HITISYSSNI DNPMVFGLVK
     SQIVLPTVVV ETMNDKEIEY IILHELSHVK SHDLIFNQLY VVFKMIFWFN PALYISKTMM
     DNDCEKVCDR NVLKILNRHE HIRYGESILK CSILKSQHIN NVAAQYLLGF NSNIKERVKY
     IALYDSMPKP NRNKRIVAYI VCSISLLIQA PLLSAHVQQD KYETNVSYKK LNQLAPYFKG
     FDGSFVLYNE REQAYSIYNE PESKQRYSPN STYKIYLALM AFDQNLLSLN HTEQQWDKHQ
     YPFKEWNQDQ NLNSSMKYSV NWYYENLNKH LRQDEVKSYL DLIEYGNEEI SGNENYWNES
     SLKISAIEQV NLLKNMKQHN MHFDNKAIEK VENSMTLKQK DTYKYVGKTG TGIVNHKEAN
     GWFVGYVETK DNTYYFATHL KGEDNANGEK AQQISERILK EMELI