MDTM_SALTY
ID MDTM_SALTY Reviewed; 413 AA.
AC Q7CP73;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Multidrug resistance protein MdtM;
GN Name=mdtM; OrderedLocusNames=STM4517;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; AE006468; AAL23335.1; -; Genomic_DNA.
DR RefSeq; NP_463376.1; NC_003197.2.
DR RefSeq; WP_001188918.1; NC_003197.2.
DR AlphaFoldDB; Q7CP73; -.
DR SMR; Q7CP73; -.
DR STRING; 99287.STM4517; -.
DR PaxDb; Q7CP73; -.
DR EnsemblBacteria; AAL23335; AAL23335; STM4517.
DR GeneID; 1256043; -.
DR KEGG; stm:STM4517; -.
DR PATRIC; fig|99287.12.peg.4758; -.
DR HOGENOM; CLU_001265_47_2_6; -.
DR OMA; YIPLMSW; -.
DR PhylomeDB; Q7CP73; -.
DR BioCyc; SENT99287:STM4517-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IBA:GO_Central.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..413
FT /note="Multidrug resistance protein MdtM"
FT /id="PRO_0000084842"
FT TOPO_DOM 1..14
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 36..51
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73..81
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..106
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..170
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 192..225
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 247..254
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 276..289
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..331
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 332..351
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 373..376
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 398..413
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 413 AA; 44792 MW; AB0EC1006F39CB58 CRC64;
MQRIIQFFSQ RATTLFFPMA LILYDFAAYL TTDLIQPGII NVVRDFNADV SLAPASVSLY
LAGGMALQWL LGPLSDRIGR RPVLIAGALI FTLACAATLL TTSMTQFLVA RFVQGTSICF
IATVGYVTVQ EAFGQTKAIK LMAIITSIVL VAPVIGPLSG AALMHFVHWK VLFGIIAVMG
LLALCGLLLA MPETVQRGAV PFSAVSVLRD FRNVFRNPIF LTGAATLSLS YIPMMSWVAV
SPVILIDAGG MSTSQFAWAQ VPVFGAVIVA NMIVVRLVKD PTRPRFIWRA VPIQLSGLAT
LLLGNLLLPH VWLWSVLGTS LYAFGIGMIF PTLFRFTLFS NNLPKGTVSA SLNMVILTVM
AVSVEVGRWL WFHGGRLPFH LLAAVAGVIV VFTLATLLQR VRQHEAAELA AEK
