ID   MDTG_RAHSY              Reviewed;         412 AA.
AC   E8XY75;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Multidrug resistance protein MdtG {ECO:0000255|HAMAP-Rule:MF_01528};
GN   Name=mdtG {ECO:0000255|HAMAP-Rule:MF_01528}; OrderedLocusNames=Rahaq_2981;
OS   Rahnella sp. (strain Y9602).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Rahnella.
OX   NCBI_TaxID=2703885;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Y9602;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Lu M., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N.,
RA   Ivanova N., Ovchinnikova G., Pagani I., Sobecky P.A., Martinez R.J.,
RA   Woyke T.;
RT   "Complete sequence of chromosome of Rahnella sp. Y9602.";
RL   Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01528}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01528}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. DHA1 family.
CC       MdtG (TC 2.A.1.2.20) subfamily. {ECO:0000255|HAMAP-Rule:MF_01528}.
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DR   EMBL; CP002505; ADW74575.1; -; Genomic_DNA.
DR   RefSeq; WP_013576271.1; NC_015061.1.
DR   AlphaFoldDB; E8XY75; -.
DR   SMR; E8XY75; -.
DR   STRING; 741091.Rahaq_2981; -.
DR   EnsemblBacteria; ADW74575; ADW74575; Rahaq_2981.
DR   KEGG; rah:Rahaq_2981; -.
DR   eggNOG; COG2814; Bacteria.
DR   HOGENOM; CLU_001265_57_3_6; -.
DR   OMA; VIRHNVP; -.
DR   OrthoDB; 626204at2; -.
DR   Proteomes; UP000007257; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   HAMAP; MF_01528; MFS_MdtG; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR023692; Mutidrug-R_MdtG.
DR   InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG.
DR   Pfam; PF07690; MFS_1; 1.
DR   PRINTS; PR01035; TCRTETA.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..412
FT                   /note="Multidrug resistance protein MdtG"
FT                   /id="PRO_0000414582"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        382..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
SQ   SEQUENCE   412 AA;  44561 MW;  C54E28D1D3B488AC CRC64;
     MTSASEPEIA PDPINWKRNL FVAWIGCFLT GAAFSLIMPF LPLYVETLGV TGHESLNMWS
     GLVFSITFLF SAIASPFWGG LADRKGRKIM LLRSALGMSI VMVLMGFAQN IWQFLILRAL
     LGLLGGFVPN ANALIATQIP RNKSGWALGT LSTGGVSGAL LGPLVGGLLA DSYGLRPVFF
     ITASVLFLCF IMTLYFIREQ FVPVSKKDML NRKQVFASLK NPKLVLCLFV TTMIIQVATG
     SIAPILTLYV RELAGNTQNL AFISGMIASV PGVAALMSAP RLGKLGDRIG PERILVAMMA
     LSVLLLIPMA LVQTPLQLGI LRFLLGACDG ALLPAVQTLL IYNCTNQVAG RVFSYNQSFR
     DVGNVTGPLL GAAVSASYGF RTVFFVTAMV VLFNAGYSYW CLQRRPHQAM ID