ID   MDTD_PECCP              Reviewed;         466 AA.
AC   C6DBD0;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Putative multidrug resistance protein MdtD {ECO:0000255|HAMAP-Rule:MF_01577};
GN   Name=mdtD {ECO:0000255|HAMAP-Rule:MF_01577}; OrderedLocusNames=PC1_2970;
OS   Pectobacterium carotovorum subsp. carotovorum (strain PC1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Pectobacterium.
OX   NCBI_TaxID=561230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PC1;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C.,
RA   Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Balakrishnan V., Glasner J., Perna N.T.;
RT   "Complete sequence of Pectobacterium carotovorum subsp. carotovorum PC1.";
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01577}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01577}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC       family. {ECO:0000255|HAMAP-Rule:MF_01577}.
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DR   EMBL; CP001657; ACT13993.1; -; Genomic_DNA.
DR   RefSeq; WP_015841148.1; NC_012917.1.
DR   AlphaFoldDB; C6DBD0; -.
DR   SMR; C6DBD0; -.
DR   STRING; 561230.PC1_2970; -.
DR   EnsemblBacteria; ACT13993; ACT13993; PC1_2970.
DR   KEGG; pct:PC1_2970; -.
DR   eggNOG; COG0477; Bacteria.
DR   HOGENOM; CLU_000960_28_0_6; -.
DR   OMA; FKIHTFS; -.
DR   OrthoDB; 1558246at2; -.
DR   Proteomes; UP000002736; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   HAMAP; MF_01577; MFS_MdtD; 1.
DR   InterPro; IPR004638; EmrB-like.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR023721; Multi-R_MdtD.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..466
FT                   /note="Putative multidrug resistance protein MdtD"
FT                   /id="PRO_1000215613"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        286..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        328..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        351..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        429..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
SQ   SEQUENCE   466 AA;  50958 MW;  A8986F2BA00C3CBA CRC64;
     MMNSASVRWQ LWIVAFGFFM QTLDTTIVNT ALPSMAASLN ESPLHMHSVI VSYVLTVAVM
     LPASGWLADR IGVKNIFFAA ILLFTLGSLL CARSETLNEL LASRVIQGIG GAMMVPVGRL
     TVMKIVPRDQ YMAAMTFVTL PGQIGPLMGP ALGGFLVEYA SWHWIFLINL PVGIIGALAT
     WFLMPNYTMR TQRFDISGFL WLAVGMATLT LALDGNRSLG IPPIAIFALI TVGLIALLSY
     WLHARRNERA LFNLRLFDTH TFSIGLTGGL LARIGSGMLP FMTPLFLQLG MGFSPFHAGL
     MMVPMVLGNM GMKRIVVQIV NRLGYRRVLI VSTLLLALVT ALFALVALMQ WIWMIPIVLF
     FLGMVNAIRF STMNTLTLKD LPDTLASGGN SLMSMTMQLS TSLGVSIAGI LLGMFSQPHM
     AAGSGETHMV FIYTYLSMIV IIALPALIFN RVPADTIKQS TLPRKS