MDM4_XENLA
ID MDM4_XENLA Reviewed; 475 AA.
AC Q7ZYI3;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Protein Mdm4;
DE AltName: Full=Double minute 4 protein;
DE AltName: Full=Mdm2-like p53-binding protein;
DE AltName: Full=Mdmx protein;
DE AltName: Full=p53-binding protein Mdm4;
GN Name=mdm4; Synonyms=mdmx;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibits p53- and p73-mediated cell cycle arrest and
CC apoptosis by binding its transcriptional activation domain.
CC {ECO:0000250}.
CC -!- SUBUNIT: Binds to p53 and p73. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MDM2/MDM4 family. {ECO:0000305}.
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DR EMBL; BC043773; AAH43773.1; -; mRNA.
DR RefSeq; NP_001082434.1; NM_001088965.1.
DR AlphaFoldDB; Q7ZYI3; -.
DR SMR; Q7ZYI3; -.
DR PRIDE; Q7ZYI3; -.
DR DNASU; 398466; -.
DR GeneID; 398466; -.
DR KEGG; xla:398466; -.
DR CTD; 398466; -.
DR Xenbase; XB-GENE-6256316; mdm4.S.
DR OrthoDB; 1329283at2759; -.
DR Proteomes; UP000186698; Chromosome 2S.
DR Bgee; 398466; Expressed in spleen and 19 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR Gene3D; 1.10.245.10; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR015458; MDM4.
DR InterPro; IPR016495; p53_neg-reg_MDM_2/4.
DR InterPro; IPR036885; SWIB_MDM2_dom_sf.
DR InterPro; IPR003121; SWIB_MDM2_domain.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13844:SF20; PTHR13844:SF20; 1.
DR Pfam; PF02201; SWIB; 1.
DR PIRSF; PIRSF500699; MDM4; 1.
DR PIRSF; PIRSF006748; p53_MDM_2/4; 1.
DR SUPFAM; SSF47592; SSF47592; 1.
DR SUPFAM; SSF90209; SSF90209; 1.
DR PROSITE; PS51925; SWIB_MDM2; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
DR PROSITE; PS50199; ZF_RANBP2_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..475
FT /note="Protein Mdm4"
FT /id="PRO_0000331518"
FT DOMAIN 26..109
FT /note="SWIB/MDM2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01273"
FT ZN_FING 296..325
FT /note="RanBP2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00322"
FT ZN_FING 422..463
FT /note="RING-type; degenerate"
FT MOTIF 427..430
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 475 AA; 53405 MW; C88161B068A79ADD CRC64;
MSTSTALHLM DEQDPAPTTI QNTEESLVRV QPALLKILQS AGAKGDMFTL KQVMHYLGQY
IMVKGLYDKQ HQHIVHCGSD ELGKLLGITT FSVKDPRPLY DMLKKNLLRI SCTDAGHSPS
RNKSQASDSL ELEKSFASKT EVTDVIKRND CVSSDMCTSF DNSHLKGNES SDYTKQSLDF
IFEEWDEAGL PWWFLGNLRT NYNLQSIGST DIPSNQDIDT ATVSDTTDDM WFLNDSRTDR
INMEVKMESS DSLEEEVGEC DSKKPAQMIE LTLYEDDDDL DDTQSLSEDT DTEVTSEECW
QCTKCHKFNS PVKRYCYRCW ALRKDWYLDF PRLIHSSSTP TLPGKVSSQM IVDGLDIPDC
RRTVSAPMVG VQVPECRSLV PFLEPLDLAA NSKAFSESTD TLLTFKAAEA SLLSSRPLLE
PCQLCQRRQR NGSVVHGRTA HLVTCFSCAC NLKKNQKGCP VCEKPIQMVV KIYVA
