MCMBP_DROME
ID MCMBP_DROME Reviewed; 605 AA.
AC Q9VM60;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Mini-chromosome maintenance complex-binding protein;
DE Short=MCM-BP;
DE Short=MCM-binding protein;
GN ORFNames=CG3430;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-147 AND SER-150, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: Associated component of the MCM complex that acts as a
CC regulator of DNA replication. Binds to the MCM complex during late S
CC phase and may act by promoting the disassembly of the MCM complex from
CC chromatin (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with the MCM complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MCMBP family. {ECO:0000305}.
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DR EMBL; AE014134; AAF52465.1; -; Genomic_DNA.
DR EMBL; AY069585; AAL39730.1; -; mRNA.
DR RefSeq; NP_542438.1; NM_080707.4.
DR AlphaFoldDB; Q9VM60; -.
DR BioGRID; 60126; 5.
DR IntAct; Q9VM60; 1.
DR STRING; 7227.FBpp0078978; -.
DR iPTMnet; Q9VM60; -.
DR PaxDb; Q9VM60; -.
DR PRIDE; Q9VM60; -.
DR DNASU; 33976; -.
DR EnsemblMetazoa; FBtr0079350; FBpp0078978; FBgn0031875.
DR GeneID; 33976; -.
DR KEGG; dme:Dmel_CG3430; -.
DR UCSC; CG3430-RA; d. melanogaster.
DR FlyBase; FBgn0031875; CG3430.
DR VEuPathDB; VectorBase:FBgn0031875; -.
DR eggNOG; KOG2545; Eukaryota.
DR GeneTree; ENSGT00390000017265; -.
DR HOGENOM; CLU_029811_0_0_1; -.
DR InParanoid; Q9VM60; -.
DR OMA; HTEMIQQ; -.
DR OrthoDB; 1011739at2759; -.
DR PhylomeDB; Q9VM60; -.
DR BioGRID-ORCS; 33976; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 33976; -.
DR PRO; PR:Q9VM60; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0031875; Expressed in secondary oocyte and 35 other tissues.
DR Genevisible; Q9VM60; DM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR InterPro; IPR019140; MCM_complex-bd.
DR PANTHER; PTHR13489; PTHR13489; 1.
DR Pfam; PF09739; MCM_bind; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; DNA replication; Mitosis; Nucleus;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..605
FT /note="Mini-chromosome maintenance complex-binding protein"
FT /id="PRO_0000405813"
FT MOD_RES 147
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 150
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
SQ SEQUENCE 605 AA; 68017 MW; E89C45FD96B2E630 CRC64;
MPCAMELPST PDELAAQQAD SAALKDLLKD PSRWHSIPLL NYTPLHKLKD QTLVRFRGMI
QDMMDPEIYL ERYEVKSADG SKRVQEGKYR DCLKIANGEV IDYNADGNVH GERRTMFVVS
VPGLNDWSKE HEKLCCPQID LASLGQSPSS AKKRTIVGEE EAMDVDVASE TTFKRPCLKE
IQKDSEPVGA SKSSVLGSDY LINSPLPDRP SMACMVKVYE EFDTYQLNSL VDFVGFLSVD
ASLDAATLEI DDCENLSELQ AAHPSPFLIP RLHAFGVQVL PHANPLLDKS LRQPTEICEE
TYPTHLAVHK DLRMLLKLCL FDDDLAAEYL LSHLISTVYS RSEMQSIGKF ALNLCNLPKN
CEAYATKLYQ ILELLLPASH YMPMTLVTLN TAAFAPKKDY ETNKLVSGVL QLAPHTHLVL
DETCMQQGKL EANGVHAVQH LAHLINNQEL KCDFQYYQID YQANIPVLVL SEGRSMLPSD
FVLPINADSK AVELVDESLK AAHHYLQPSR LQQFRKYLTT ARTSGFNVSE EHTEMIQQDF
VDMRKANVKS NADDLHGLLV LSRLLGIARG KDTLDKETWQ LATEFEAKRR QRIQSLPKSS
AQLRN
