ID   MCHR1_PIG               Reviewed;         121 AA.
AC   Q9MZ01;
DT   15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Melanin-concentrating hormone receptor 1;
DE            Short=MCH receptor 1;
DE            Short=MCH-R1;
DE            Short=MCHR-1;
DE   AltName: Full=G-protein coupled receptor 24;
DE   AltName: Full=MCH-1R;
DE            Short=MCH1R;
DE            Short=MCHR;
DE   Flags: Fragment;
GN   Name=MCHR1; Synonyms=GPR24;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hypothalamus;
RA   Matteri R.L.;
RT   "Sus scrofa melanin-concentrating hormone (MCH) receptor.";
RL   Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for melanin-concentrating hormone, coupled to both G
CC       proteins that inhibit adenylyl cyclase and G proteins that activate
CC       phosphoinositide hydrolysis. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with NCDN. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF273611; AAF81827.1; -; mRNA.
DR   AlphaFoldDB; Q9MZ01; -.
DR   SMR; Q9MZ01; -.
DR   STRING; 9823.ENSSSCP00000000079; -.
DR   PaxDb; Q9MZ01; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   HOGENOM; CLU_009579_8_1_1; -.
DR   InParanoid; Q9MZ01; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   Genevisible; Q9MZ01; SS.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0030273; F:melanin-concentrating hormone receptor activity; IEA:InterPro.
DR   GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR   GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR004047; MCHR1.
DR   PANTHER; PTHR24229:SF91; PTHR24229:SF91; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01507; MCH1RECEPTOR.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           <1..>121
FT                   /note="Melanin-concentrating hormone receptor 1"
FT                   /id="PRO_0000069738"
FT   TOPO_DOM        <1..33
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        55..70
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        92..>121
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         121
SQ   SEQUENCE   121 AA;  13583 MW;  884D8268B6F9F010 CRC64;
     TAAYVRILQR MTSSVAPASQ RSIRLRTKRV TRTAIAICLV FFVCWAPYYV LQLTQLSISR
     PTLTFVYLYN AAISLGYANS CLNPFVYIVL CETFRKRLVL SVKPAAQGQL RAVSNAQTAE
     E