MCFW_DICDI
ID MCFW_DICDI Reviewed; 329 AA.
AC Q54FU9;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Mitochondrial substrate carrier family protein W;
GN Name=mcfW; ORFNames=DDB_G0290669;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP REVIEW.
RX PubMed=17442478; DOI=10.1016/j.biochi.2007.03.004;
RA Satre M., Mattei S., Aubry L., Gaudet P., Pelosi L., Brandolin G.,
RA Klein G.;
RT "Mitochondrial carrier family: repertoire and peculiarities of the cellular
RT slime mould Dictyostelium discoideum.";
RL Biochimie 89:1058-1069(2007).
CC -!- FUNCTION: Mitochondrial solute carriers shuttle metabolites,
CC nucleotides, and cofactors through the mitochondrial inner membrane.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000164; EAL62195.1; -; Genomic_DNA.
DR RefSeq; XP_635668.1; XM_630576.1.
DR AlphaFoldDB; Q54FU9; -.
DR SMR; Q54FU9; -.
DR PaxDb; Q54FU9; -.
DR EnsemblProtists; EAL62195; EAL62195; DDB_G0290669.
DR GeneID; 8627740; -.
DR KEGG; ddi:DDB_G0290669; -.
DR dictyBase; DDB_G0290669; mcfW.
DR eggNOG; KOG0764; Eukaryota.
DR HOGENOM; CLU_015166_6_4_1; -.
DR InParanoid; Q54FU9; -.
DR OMA; PTWAVYM; -.
DR PhylomeDB; Q54FU9; -.
DR PRO; PR:Q54FU9; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051724; F:NAD transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0035352; P:NAD transmembrane transport; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 2.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR044712; SLC25A32-like.
DR PANTHER; PTHR45683; PTHR45683; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..329
FT /note="Mitochondrial substrate carrier family protein W"
FT /id="PRO_0000385529"
FT TOPO_DOM 1..39
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 40..60
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..90
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 91..111
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..135
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 136..156
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..193
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 194..214
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..230
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 231..251
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 252..296
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 297..315
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..329
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT REPEAT 34..119
FT /note="Solcar 1"
FT REPEAT 133..221
FT /note="Solcar 2"
FT REPEAT 231..321
FT /note="Solcar 3"
SQ SEQUENCE 329 AA; 37321 MW; 6B5134E2DE130788 CRC64;
MTTNNSNDNN KRYGIIKQQL QQQQQQHHQQ HEQHSRLVEM TAGCGAGFMA SLFTTPLDVI
KTTLQVDNSS NKTIMSTVKS ILDRKGGVKN LYLGLKPTLV GQIPSWAVYF STYTFCKELF
TKENDKHSLL EKESPLIFMT SAIIAGAATS ICTSPIWLIK TRFITQEMVG RQKKYRGIVH
SMVSIYHEEG FRGLYKGLGP SLLGVLHVGV QFPLYEKFKS ILKEKNKNKE LGIVEIMIAS
SVSKIIASVV AYPHEVLRAR SQDSSPDSPN RTYRGNIIQM FKQIVREEGW RGLYRGMGVN
LLRVTPSCVI TFTSYEYIKK FLSQNQNHF
