MCFE_DICDI
ID MCFE_DICDI Reviewed; 303 AA.
AC Q55E45;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Mitochondrial substrate carrier family protein E;
GN Name=mcfE; ORFNames=DDB_G0269394;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP REVIEW.
RX PubMed=17442478; DOI=10.1016/j.biochi.2007.03.004;
RA Satre M., Mattei S., Aubry L., Gaudet P., Pelosi L., Brandolin G.,
RA Klein G.;
RT "Mitochondrial carrier family: repertoire and peculiarities of the cellular
RT slime mould Dictyostelium discoideum.";
RL Biochimie 89:1058-1069(2007).
CC -!- FUNCTION: Mitochondrial solute carriers shuttle metabolites,
CC nucleotides, and cofactors through the mitochondrial inner membrane.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000005; EAL72047.1; -; Genomic_DNA.
DR RefSeq; XP_645936.1; XM_640844.1.
DR AlphaFoldDB; Q55E45; -.
DR SMR; Q55E45; -.
DR STRING; 44689.DDB0237609; -.
DR PaxDb; Q55E45; -.
DR EnsemblProtists; EAL72047; EAL72047; DDB_G0269394.
DR GeneID; 8616880; -.
DR KEGG; ddi:DDB_G0269394; -.
DR dictyBase; DDB_G0269394; mcfE.
DR eggNOG; KOG0770; Eukaryota.
DR HOGENOM; CLU_015166_3_4_1; -.
DR InParanoid; Q55E45; -.
DR OMA; VWVPIDV; -.
DR PhylomeDB; Q55E45; -.
DR PRO; PR:Q55E45; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..303
FT /note="Mitochondrial substrate carrier family protein E"
FT /id="PRO_0000385521"
FT TOPO_DOM 1..8
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 9..29
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..67
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 68..88
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..109
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 110..130
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..171
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 172..192
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 193..215
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 216..236
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 237..268
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 269..289
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..303
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT REPEAT 6..93
FT /note="Solcar 1"
FT REPEAT 104..197
FT /note="Solcar 2"
FT REPEAT 210..298
FT /note="Solcar 3"
SQ SEQUENCE 303 AA; 34018 MW; 637BFC649C282AB1 CRC64;
MENKKESSLL YILTGATSGL LADSIMHPVD TVRARVQIEK VGKSQYKGTF NALNQIIKNE
GVSYLYKGFP IVATATVPAH ALYFLGYEYS KQWVTDRYGK KWGESTITHF SAGFVADALG
SLIWVPMDII KQRLQVQTNT QKLNPNQTYY KGSFHAGKII LQEEGIRGLY RGFMPALATY
GPFVGIYFSV YEKCKSTISS LLSKEKDQYL PIPYQLGSGF FAGAFAAAVT CPLDVIKTRI
QVQRSTEKQI YKGMWDSFKT ILKEEGPKAF VKGMGARIWW IAPGNALTIA SYEQLKYLFK
DLI
