MCATL_RAT
ID MCATL_RAT Reviewed; 306 AA.
AC Q5HZE0;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Mitochondrial basic amino acids transporter;
DE AltName: Full=Carnitine/acylcarnitine translocase-like;
DE Short=CACT-like;
DE AltName: Full=Mitochondrial carnitine/acylcarnitine carrier protein CACL;
DE AltName: Full=Mitochondrial ornithine transporter 3;
DE AltName: Full=Solute carrier family 25 member 29;
GN Name=Slc25a29; Synonyms=Ornt3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Transports arginine, lysine, homoarginine, methylarginine
CC and, to a much lesser extent, ornithine and histidine. Can restore
CC ornithine transport in cells lacking the primary mitochondrial
CC ornithine transporter SLC25A15. Does not transport carnitine nor
CC acylcarnitines. Functions by both counter-exchange and uniport
CC mechanisms. {ECO:0000250|UniProtKB:Q8N8R3}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q8BL03}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q8BL03}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; BC089065; AAH89065.1; -; mRNA.
DR RefSeq; NP_001010958.1; NM_001010958.1.
DR AlphaFoldDB; Q5HZE0; -.
DR SMR; Q5HZE0; -.
DR STRING; 10116.ENSRNOP00000005753; -.
DR PaxDb; Q5HZE0; -.
DR PRIDE; Q5HZE0; -.
DR GeneID; 314441; -.
DR KEGG; rno:314441; -.
DR UCSC; RGD:1308104; rat.
DR CTD; 123096; -.
DR RGD; 1308104; Slc25a29.
DR VEuPathDB; HostDB:ENSRNOG00000004351; -.
DR eggNOG; KOG0762; Eukaryota.
DR HOGENOM; CLU_015166_16_1_1; -.
DR InParanoid; Q5HZE0; -.
DR OMA; IFWLTSY; -.
DR OrthoDB; 1072378at2759; -.
DR PhylomeDB; Q5HZE0; -.
DR TreeFam; TF351739; -.
DR Reactome; R-RNO-352230; Amino acid transport across the plasma membrane.
DR PRO; PR:Q5HZE0; -.
DR Proteomes; UP000002494; Chromosome 6.
DR Bgee; ENSRNOG00000004351; Expressed in pancreas and 19 other tissues.
DR Genevisible; Q5HZE0; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0015227; F:acyl carnitine transmembrane transporter activity; ISO:RGD.
DR GO; GO:0015174; F:basic amino acid transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0005289; F:high-affinity L-arginine transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0005292; F:high-affinity lysine transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006844; P:acyl carnitine transport; ISO:RGD.
DR GO; GO:1903826; P:L-arginine transmembrane transport; ISS:UniProtKB.
DR GO; GO:0089709; P:L-histidine transmembrane transport; ISS:UniProtKB.
DR GO; GO:1903401; P:L-lysine transmembrane transport; ISS:UniProtKB.
DR GO; GO:1990575; P:mitochondrial L-ornithine transmembrane transport; ISS:UniProtKB.
DR GO; GO:0015822; P:ornithine transport; ISS:UniProtKB.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..306
FT /note="Mitochondrial basic amino acids transporter"
FT /id="PRO_0000329031"
FT TRANSMEM 2..22
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..172
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..275
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 2..86
FT /note="Solcar 1"
FT REPEAT 90..178
FT /note="Solcar 2"
FT REPEAT 190..275
FT /note="Solcar 3"
FT REGION 283..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 306 AA; 32635 MW; 7C55B36754CB63CC CRC64;
MALDFLAGCA GGVAGVIVGH PFDTVKVRLQ VQNTEKPQYR GTLHCFQSII KQESVLGLYK
GLGSPLMGLT FINALVFGVQ GNTLRALGQD SPLNQFLAGA AAGAIQCVIC CPMELAKTRL
QLQAAGPARA YKGSLDCLVQ IYRHEGLRGI NRGMVSTLLR ETPSFGVYFL TYDVLTRAMG
CEPGDRLLVP KLLLAGGTSG ITSWLSTYPM DVVKSRLQAD GLQGTPRYRG IVDCMRQSYQ
AEGWQVFTRG LASTLLRAFP VNAATFATVT VVLTYIRGEE DQVDSEAAPG ASTTPAGPAL
AQPSSL
