ID   MCATL_BOVIN             Reviewed;         298 AA.
AC   Q08DK7;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Mitochondrial basic amino acids transporter;
DE   AltName: Full=Carnitine/acylcarnitine translocase-like;
DE            Short=CACT-like;
DE   AltName: Full=Mitochondrial carnitine/acylcarnitine carrier protein CACL;
DE   AltName: Full=Mitochondrial ornithine transporter 3;
DE   AltName: Full=Solute carrier family 25 member 29;
GN   Name=SLC25A29; Synonyms=ORNT3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hippocampus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transports arginine, lysine, homoarginine, methylarginine
CC       and, to a much lesser extent, ornithine and histidine. Can restore
CC       ornithine transport in cells lacking the primary mitochondrial
CC       ornithine transporter SLC25A15. Does not transport carnitine nor
CC       acylcarnitines. Functions by both counter-exchange and uniport
CC       mechanisms. {ECO:0000250|UniProtKB:Q8N8R3}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q8BL03}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q8BL03}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; BC123695; AAI23696.1; -; mRNA.
DR   RefSeq; NP_001071339.1; NM_001077871.1.
DR   AlphaFoldDB; Q08DK7; -.
DR   SMR; Q08DK7; -.
DR   STRING; 9913.ENSBTAP00000018163; -.
DR   PaxDb; Q08DK7; -.
DR   PRIDE; Q08DK7; -.
DR   Ensembl; ENSBTAT00000018163; ENSBTAP00000018163; ENSBTAG00000013666.
DR   GeneID; 507686; -.
DR   KEGG; bta:507686; -.
DR   CTD; 123096; -.
DR   VEuPathDB; HostDB:ENSBTAG00000013666; -.
DR   VGNC; VGNC:34755; SLC25A29.
DR   eggNOG; KOG0762; Eukaryota.
DR   GeneTree; ENSGT00940000157766; -.
DR   HOGENOM; CLU_015166_16_1_1; -.
DR   InParanoid; Q08DK7; -.
DR   OMA; IFWLTSY; -.
DR   OrthoDB; 1072378at2759; -.
DR   TreeFam; TF351739; -.
DR   Reactome; R-BTA-352230; Amino acid transport across the plasma membrane.
DR   Proteomes; UP000009136; Chromosome 21.
DR   Bgee; ENSBTAG00000013666; Expressed in parenchyma of mammary gland and 106 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0015174; F:basic amino acid transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0005289; F:high-affinity L-arginine transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0005292; F:high-affinity lysine transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006844; P:acyl carnitine transport; IEA:Ensembl.
DR   GO; GO:1903826; P:L-arginine transmembrane transport; ISS:UniProtKB.
DR   GO; GO:0089709; P:L-histidine transmembrane transport; ISS:UniProtKB.
DR   GO; GO:1903401; P:L-lysine transmembrane transport; ISS:UniProtKB.
DR   GO; GO:1990575; P:mitochondrial L-ornithine transmembrane transport; ISS:UniProtKB.
DR   GO; GO:0015822; P:ornithine transport; ISS:UniProtKB.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Amino-acid transport; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..298
FT                   /note="Mitochondrial basic amino acids transporter"
FT                   /id="PRO_0000329030"
FT   TRANSMEM        2..22
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..172
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          2..86
FT                   /note="Solcar 1"
FT   REPEAT          90..178
FT                   /note="Solcar 2"
FT   REPEAT          185..275
FT                   /note="Solcar 3"
SQ   SEQUENCE   298 AA;  31866 MW;  CA830A3343DC23F5 CRC64;
     MALDFLAGCA GGVAGVLVGH PFDTVKVRLQ VQSVEKPQYR GTLHCFQAII KQESVLGLYR
     GLGSPLLGLT FINALVFGVQ GNTLRALGRD SPLNQFLAGA AAGAIQCVIC CPMELAKTRL
     QLQEAGPART YRGPLDCLAQ IYRQEGLRGV NRGMVSTLLR ETPSFGVYFL TYDVLTRALG
     CEPGDRLLVP KLLLAGGTSG IASWLSTYPV DVVKSRLQAD GLQGAPRYRG IVDCVQQSYR
     EEGWRVFTRG LASTLLRAFP VNAATFATVT VVLSYARGEE ARLEGDAGSA ALAQPSSL