ID   MCAR_MIMIV              Reviewed;         237 AA.
AC   Q5UPV8;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   07-OCT-2020, entry version 77.
DE   RecName: Full=Mitochondrial carrier-like protein L276;
DE   AltName: Full=VMC1;
DE   AltName: Full=Viral mitochondrial carrier;
GN   OrderedLocusNames=MIMI_L276;
OS   Acanthamoeba polyphaga mimivirus (APMV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Imitervirales; Mimiviridae; Mimivirus.
OX   NCBI_TaxID=212035;
OH   NCBI_TaxID=5757; Acanthamoeba polyphaga (Amoeba).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rowbotham-Bradford;
RX   PubMed=15486256; DOI=10.1126/science.1101485;
RA   Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H.,
RA   La Scola B., Susan M., Claverie J.-M.;
RT   "The 1.2-megabase genome sequence of Mimivirus.";
RL   Science 306:1344-1350(2004).
RN   [2]
RP   FUNCTION.
RX   PubMed=17229695; DOI=10.1128/jvi.02386-06;
RA   Monne M., Robinson A.J., Boes C., Harbour M.E., Fearnley I.M., Kunji E.R.;
RT   "The mimivirus genome encodes a mitochondrial carrier that transports dATP
RT   and dTTP.";
RL   J. Virol. 81:3181-3186(2007).
CC   -!- FUNCTION: Transports dATP and to a lesser extent dTTP, TTP, UTP and
CC       ADP, possibly across the mitochondrial inner membrane.
CC       {ECO:0000269|PubMed:17229695}.
CC   -!- SUBCELLULAR LOCATION: Host mitochondrion inner membrane {ECO:0000305};
CC       Multi-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; AY653733; AAV50548.1; -; Genomic_DNA.
DR   RefSeq; YP_003986777.1; NC_014649.1.
DR   SMR; Q5UPV8; -.
DR   TCDB; 2.A.29.26.1; the mitochondrial carrier (mc) family.
DR   GeneID; 9924890; -.
DR   KEGG; vg:9924890; -.
DR   Proteomes; UP000001134; Genome.
DR   GO; GO:0044192; C:host cell mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 2.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   3: Inferred from homology;
KW   Host membrane; Host mitochondrion; Host mitochondrion inner membrane;
KW   Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..237
FT                   /note="Mitochondrial carrier-like protein L276"
FT                   /id="PRO_0000243922"
FT   TRANSMEM        11..27
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..76
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..108
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..183
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..226
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1..83
FT                   /note="Solcar 1"
FT   REPEAT          85..161
FT                   /note="Solcar 2"
FT   REPEAT          164..233
FT                   /note="Solcar 3"
FT   MOTIF           191..196
FT                   /note="Substrate recognition"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   237 AA;  27319 MW;  C7565CFB07580A08 CRC64;
     MAKYTDITNS AIATIVAEII TLPICTFKTN YQNNSTLSMQ QCLKNIYMKN GISGFYKASV
     PAIMSQTYST SSKYFLFRFF ENKNYPYTNK MINGIISGIM TSLITHPIDN IKIHLQMNDS
     FMCKLRENGF GLFYRGYSKS FGKTVISSSM FFPLYETLNE YFEKPVVSSM LTAIISTTIM
     QPLDFLKTRH IYGLSLYNGL NLQHYYRGLS LNLMRIVPHF VITMTTIDFL NKKTLQY