MCAF1_CHICK
ID MCAF1_CHICK Reviewed; 1085 AA.
AC Q5ZIE8;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Activating transcription factor 7-interacting protein 1;
DE AltName: Full=MBD1-containing chromatin-associated factor 1;
GN Name=ATF7IP; Synonyms=MCAF1; ORFNames=RCJMB04_27g4;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Recruiter that couples transcriptional factors to general
CC transcription apparatus and thereby modulates transcription regulation
CC and chromatin formation. Can both act as an activator or a repressor
CC depending on the context. Mediates MBD1-dependent transcriptional
CC repression, probably by recruiting complexes containing histone
CC methyltransferase activity. May belong to a complex that represses
CC transcription and couples DNA methylation and histone H3 'Lys-9'
CC trimethylation (H3K9me3) (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MCAF family. {ECO:0000305}.
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DR EMBL; AJ720836; CAG32495.1; -; mRNA.
DR RefSeq; NP_001012831.1; NM_001012813.1.
DR AlphaFoldDB; Q5ZIE8; -.
DR STRING; 9031.ENSGALP00000041710; -.
DR PaxDb; Q5ZIE8; -.
DR PRIDE; Q5ZIE8; -.
DR GeneID; 417966; -.
DR KEGG; gga:417966; -.
DR CTD; 55729; -.
DR VEuPathDB; HostDB:geneid_417966; -.
DR eggNOG; ENOG502QSM2; Eukaryota.
DR InParanoid; Q5ZIE8; -.
DR OrthoDB; 88757at2759; -.
DR PhylomeDB; Q5ZIE8; -.
DR PRO; PR:Q5ZIE8; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0090309; P:positive regulation of DNA methylation-dependent heterochromatin assembly; ISS:UniProtKB.
DR GO; GO:0050821; P:protein stabilization; ISS:UniProtKB.
DR GO; GO:0031647; P:regulation of protein stability; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR026085; ATF7-int.
DR InterPro; IPR031870; ATF7IP_BD.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR23210; PTHR23210; 2.
DR Pfam; PF16788; ATF7IP_BD; 1.
DR Pfam; PF16794; fn3_4; 1.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 1.
PE 2: Evidence at transcript level;
KW Activator; Coiled coil; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..1085
FT /note="Activating transcription factor 7-interacting
FT protein 1"
FT /id="PRO_0000281782"
FT DOMAIN 976..1082
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 47..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 932..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 446..480
FT /evidence="ECO:0000255"
FT COMPBIAS 64..95
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..381
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..775
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 828..843
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 948..971
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1085 AA; 117377 MW; 14B3B5B1758AD3BF CRC64;
MDNTDEPQKK VFKARKTMRA SDRQQLEAVY KAKEDLLKTT EVKLLNGKHE NGDSDLNSPL
SNTDCTEDKR EVNGLVDSNE ISEIKRPESR AESVVSDLEP KPLSPVNVTR EQDTDVALVC
EAENRVLGSN KVNFHEENNI KNRLDQRESD TPSGENKSNC DNSFSPEEKG KTNDITIISN
SPVEEKKKAG EIIVEDTVGE EAISSSMETD QEPKNERDGT AGLSETVVEK AVDESSESIL
ENTDSMEADE IIPILEKLAP AEDEMSCFSK SALLPVDDTA PDLEEKMDNC LSSPLKQESN
ESLPKEAFLV LSDEEDPCDE REHAEVILPN KSGLPEEVEK SEEEDKEREV VHKEEEKHTE
RGEVSRRKRS KSEDMDSVHS KRRRFVGEED YEAEFQVKIT ARRDVDQKLE KVIQRVLEEK
LAALQCAVFD KTLADLKMRI EKVECNKRHK TVLTELQAKI TRLTKRFGAA KEDMKKKQEN
TPNPSLSSGK AASSTANANN LTYRNITTVR QMLESKRNVG DSKPATLQAP VSAAPASSLA
APQTPASGHP KPQTPVTSSP LTTTVISTAN TATVVGTSQV PSGSTQPMSV SLQSLPVILH
VPVAVSSQPQ LLQGHAGTLV TNQQSGSVEF ISVQSSSTVG SLTKTAVSLA STNTTKPNNS
PSVSSPGVQR NSPASAGSVR TTLAVQAVST THPVAQTTRT SLPTVGTSGL HNSTSSRGPI
HMKIPLSAFN STAPTEPPTI TAPRVENQTS RPPTDSSANK RTAEGPTQSV KVTGSDSGGV
IDLTLDDEDD VSSQAEAKKQ NQTASTAQSI PTQPLSRPLP PLQPNPLQQT GVPTSGPSQT
TIHVLPTAPT TVNVTHRPVT QTAAKLPIPR TPTNHQVVYT TIPAPPAQNS VRGAVMPSPS
LRPVNPQTGS MTVRMPQTTA YVVNNGLTLG SGAPQLTVHH RPPQVHAEPP RPVHPAPLPE
APQPPRLPPE AANTSLPQKP QLKLARVQSQ NGIVLSWSVI EVDRSCASVD SYHLYAYHED
PSATMPSQWK KIGEVKALPL PMACTLTQFV SGSKYYFAVR AKDIYGRFGP FCDPQSTDVI
SSQSS
