MAPR4_ARATH
ID MAPR4_ARATH Reviewed; 245 AA.
AC Q2HIW2; O23350; Q8LGC2;
DT 26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Membrane-associated progesterone-binding protein 4 {ECO:0000303|Ref.7};
DE Short=AtMAPR4 {ECO:0000303|Ref.7};
GN Name=MAPR4 {ECO:0000303|Ref.7};
GN OrderedLocusNames=At4g14965 {ECO:0000312|Araport:AT4G14965};
GN ORFNames=dl3515w {ECO:0000312|EMBL:CAB46053.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9461215; DOI=10.1038/35140;
RA Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C.,
RA Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., Ridley P.,
RA Hudson S.-A., Patel K., Murphy G., Piffanelli P., Wedler H., Wedler E.,
RA Wambutt R., Weitzenegger T., Pohl T., Terryn N., Gielen J., Villarroel R.,
RA De Clercq R., van Montagu M., Lecharny A., Aubourg S., Gy I., Kreis M.,
RA Lao N., Kavanagh T., Hempel S., Kotter P., Entian K.-D., Rieger M.,
RA Schaefer M., Funk B., Mueller-Auer S., Silvey M., James R., Monfort A.,
RA Pons A., Puigdomenech P., Douka A., Voukelatou E., Milioni D.,
RA Hatzopoulos P., Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A.,
RA Moores T., Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S.,
RA Ansorge W., Cooke R., Berger C., Delseny M., Voet M., Volckaert G.,
RA Mewes H.-W., Klosterman S., Schueller C., Chalwatzis N.;
RT "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis
RT thaliana.";
RL Nature 391:485-488(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP INDUCTION BY AUXIN, AND NOMENCLATURE.
RA Kao A.L., Chang T.Y., Chang S.H., Su J.C., Yang C.C.;
RT "Characterization of a novel Arabidopsis protein family AtMAPR homologous
RT to 25-Dx/IZAg/Hpr6.6 proteins.";
RL Bot. Bull. Acad. Sin. 46:107-118(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- INDUCTION: By auxin. {ECO:0000269|Ref.7}.
CC -!- DOMAIN: The cytochrome b5 heme-binding domain lacks one of the
CC conserved iron-binding His residues at position 100. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cytochrome b5 family. MAPR subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB46053.1; Type=Erroneous gene model prediction; Note=The predicted gene At4g14950 has been split into 2 genes: At4g14950 and At4g14965.; Evidence={ECO:0000305};
CC Sequence=CAB78537.1; Type=Erroneous gene model prediction; Note=The predicted gene At4g14950 has been split into 2 genes: At4g14950 and At4g14965.; Evidence={ECO:0000305};
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DR EMBL; Z97337; CAB46053.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161540; CAB78537.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE83531.1; -; Genomic_DNA.
DR EMBL; BT024469; ABD19650.1; -; mRNA.
DR EMBL; AK229457; BAF01315.1; -; mRNA.
DR EMBL; AY084353; AAM60935.1; -; mRNA.
DR PIR; C85164; C85164.
DR PIR; H71412; H71412.
DR RefSeq; NP_567451.1; NM_117583.8.
DR AlphaFoldDB; Q2HIW2; -.
DR SMR; Q2HIW2; -.
DR STRING; 3702.AT4G14965.1; -.
DR PaxDb; Q2HIW2; -.
DR PRIDE; Q2HIW2; -.
DR ProteomicsDB; 238842; -.
DR EnsemblPlants; AT4G14965.1; AT4G14965.1; AT4G14965.
DR GeneID; 827155; -.
DR Gramene; AT4G14965.1; AT4G14965.1; AT4G14965.
DR KEGG; ath:AT4G14965; -.
DR Araport; AT4G14965; -.
DR TAIR; locus:505006467; AT4G14965.
DR eggNOG; KOG1108; Eukaryota.
DR HOGENOM; CLU_065455_1_0_1; -.
DR InParanoid; Q2HIW2; -.
DR OMA; GHKHYGP; -.
DR OrthoDB; 1355837at2759; -.
DR PhylomeDB; Q2HIW2; -.
DR PRO; PR:Q2HIW2; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q2HIW2; baseline and differential.
DR Genevisible; Q2HIW2; AT.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR Gene3D; 3.10.120.10; -; 1.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR Pfam; PF00173; Cyt-b5; 1.
DR SMART; SM01117; Cyt-b5; 1.
DR SUPFAM; SSF55856; SSF55856; 1.
PE 2: Evidence at transcript level;
KW Lipid-binding; Membrane; Reference proteome; Steroid-binding;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..245
FT /note="Membrane-associated progesterone-binding protein 4"
FT /id="PRO_0000430954"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 39..138
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00279"
FT REGION 45..138
FT /note="Steroid-binding"
FT /evidence="ECO:0000303|Ref.7"
FT CONFLICT 37
FT /note="Y -> D (in Ref. 6; AAM60935)"
FT CONFLICT 75
FT /note="F -> S (in Ref. 6; AAM60935)"
FT CONFLICT 132
FT /note="T -> I (in Ref. 6; AAM60935)"
FT CONFLICT 177
FT /note="S -> T (in Ref. 6; AAM60935)"
SQ SEQUENCE 245 AA; 27167 MW; A1817F353BAB1378 CRC64;
MIPARRFLLS PFVGVTFIVV LVSLYFRSSF KSPQHQYQKR LFSAEELALY NGTDETLPIL
LGILGSVFDV TKGKFHYGSG GGYNHFAGRD ASRAFVSGNF TGDGLTDSLQ GLSSSEVKSI
VDWRGFYSRT YTPVGKLVGR YYDSQGNPTK HLKGAEAKAS RGAQLMEKQK TEEAKQSNCN
SRWSQDEGGE VWCDVGVPRL VQRPLEIAIT GSMSKRCACF EEDQLDQSGL EIYKDCEPLA
KTCRV
