MAGC3_HUMAN
ID MAGC3_HUMAN Reviewed; 643 AA.
AC Q8TD91; Q3SYA7; Q5JZ43; Q9BZ80;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Melanoma-associated antigen C3;
DE AltName: Full=Cancer/testis antigen 7.2;
DE Short=CT7.2;
DE AltName: Full=Hepatocellular carcinoma-associated antigen 2;
DE AltName: Full=MAGE-C3 antigen;
GN Name=MAGEC3; Synonyms=HCA2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Dong X.-Y., Chen W.-F.;
RT "Identification of genes in the chromosome X that are differentially
RT expressed in hepatocellular carcinoma.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 362-538, AND TISSUE SPECIFICITY.
RC TISSUE=Blood;
RX PubMed=10861452;
RX DOI=10.1002/1097-0215(20000701)87:1<55::aid-ijc8>3.0.co;2-j;
RA Lucas S., De Plaen E., Boon T.;
RT "MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE
RT family with tumor-specific expression.";
RL Int. J. Cancer 87:55-60(2000).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-478; THR-484 AND THR-485, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=18318008; DOI=10.1002/pmic.200700884;
RA Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,
RA Zou H., Gu J.;
RT "Large-scale phosphoproteome analysis of human liver tissue by enrichment
RT and fractionation of phosphopeptides with strong anion exchange
RT chromatography.";
RL Proteomics 8:1346-1361(2008).
CC -!- INTERACTION:
CC Q8TD91-2; O75190: DNAJB6; NbExp=3; IntAct=EBI-10694180, EBI-1053164;
CC Q8TD91-2; Q01658: DR1; NbExp=3; IntAct=EBI-10694180, EBI-750300;
CC Q8TD91-2; P21333-2: FLNA; NbExp=3; IntAct=EBI-10694180, EBI-9641086;
CC Q8TD91-2; P78333: GPC5; NbExp=3; IntAct=EBI-10694180, EBI-2558325;
CC Q8TD91-2; Q9Y5Q9: GTF3C3; NbExp=3; IntAct=EBI-10694180, EBI-1054873;
CC Q8TD91-2; Q99750: MDFI; NbExp=3; IntAct=EBI-10694180, EBI-724076;
CC Q8TD91-2; Q8N2W9: PIAS4; NbExp=3; IntAct=EBI-10694180, EBI-473160;
CC Q8TD91-2; P37840: SNCA; NbExp=3; IntAct=EBI-10694180, EBI-985879;
CC Q8TD91-2; Q13148: TARDBP; NbExp=6; IntAct=EBI-10694180, EBI-372899;
CC Q8TD91-2; Q7RTU0: TCF24; NbExp=3; IntAct=EBI-10694180, EBI-18239606;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8TD91-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TD91-2; Sequence=VSP_043489, VSP_043490, VSP_043491;
CC -!- TISSUE SPECIFICITY: Expressed in testis. Not expressed in other normal
CC tissues, but is expressed in tumors of different histological origins.
CC {ECO:0000269|PubMed:10861452}.
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DR EMBL; AF490508; AAM08355.1; -; mRNA.
DR EMBL; AL022152; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL023279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL049177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC103893; AAI03894.1; -; mRNA.
DR EMBL; AF333706; AAK00358.1; -; Genomic_DNA.
DR CCDS; CCDS14676.1; -. [Q8TD91-1]
DR CCDS; CCDS14677.1; -. [Q8TD91-2]
DR RefSeq; NP_619647.1; NM_138702.1. [Q8TD91-1]
DR RefSeq; NP_803251.1; NM_177456.2. [Q8TD91-2]
DR RefSeq; XP_011529569.1; XM_011531267.2. [Q8TD91-2]
DR RefSeq; XP_016884754.1; XM_017029265.1. [Q8TD91-2]
DR AlphaFoldDB; Q8TD91; -.
DR SMR; Q8TD91; -.
DR BioGRID; 126542; 8.
DR IntAct; Q8TD91; 14.
DR STRING; 9606.ENSP00000298296; -.
DR iPTMnet; Q8TD91; -.
DR PhosphoSitePlus; Q8TD91; -.
DR BioMuta; MAGEC3; -.
DR DMDM; 41017367; -.
DR MassIVE; Q8TD91; -.
DR MaxQB; Q8TD91; -.
DR PaxDb; Q8TD91; -.
DR PeptideAtlas; Q8TD91; -.
DR PRIDE; Q8TD91; -.
DR ProteomicsDB; 74253; -. [Q8TD91-2]
DR Antibodypedia; 45024; 75 antibodies from 20 providers.
DR DNASU; 139081; -.
DR Ensembl; ENST00000298296.1; ENSP00000298296.1; ENSG00000165509.13. [Q8TD91-1]
DR Ensembl; ENST00000409007.1; ENSP00000386566.1; ENSG00000165509.13. [Q8TD91-2]
DR Ensembl; ENST00000544766.5; ENSP00000440444.1; ENSG00000165509.13. [Q8TD91-2]
DR GeneID; 139081; -.
DR KEGG; hsa:139081; -.
DR MANE-Select; ENST00000298296.1; ENSP00000298296.1; NM_138702.1; NP_619647.1.
DR UCSC; uc004fbs.3; human. [Q8TD91-1]
DR CTD; 139081; -.
DR DisGeNET; 139081; -.
DR GeneCards; MAGEC3; -.
DR HGNC; HGNC:23798; MAGEC3.
DR HPA; ENSG00000165509; Tissue enriched (brain).
DR MIM; 300469; gene.
DR neXtProt; NX_Q8TD91; -.
DR OpenTargets; ENSG00000165509; -.
DR PharmGKB; PA134916199; -.
DR VEuPathDB; HostDB:ENSG00000165509; -.
DR eggNOG; KOG4562; Eukaryota.
DR GeneTree; ENSGT00940000164981; -.
DR HOGENOM; CLU_508623_0_0_1; -.
DR InParanoid; Q8TD91; -.
DR OMA; NSSTWHA; -.
DR OrthoDB; 1195799at2759; -.
DR PhylomeDB; Q8TD91; -.
DR TreeFam; TF328505; -.
DR PathwayCommons; Q8TD91; -.
DR SignaLink; Q8TD91; -.
DR BioGRID-ORCS; 139081; 12 hits in 696 CRISPR screens.
DR ChiTaRS; MAGEC3; human.
DR GenomeRNAi; 139081; -.
DR Pharos; Q8TD91; Tdark.
DR PRO; PR:Q8TD91; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q8TD91; protein.
DR Bgee; ENSG00000165509; Expressed in C1 segment of cervical spinal cord and 85 other tissues.
DR ExpressionAtlas; Q8TD91; baseline and differential.
DR Genevisible; Q8TD91; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.1200; -; 2.
DR Gene3D; 1.10.10.1210; -; 2.
DR InterPro; IPR037445; MAGE.
DR InterPro; IPR041898; MAGE_WH1.
DR InterPro; IPR041899; MAGE_WH2.
DR InterPro; IPR002190; MHD_dom.
DR PANTHER; PTHR11736; PTHR11736; 2.
DR SMART; SM01373; MAGE; 2.
DR PROSITE; PS50838; MAGE; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome; Repeat;
KW Tumor antigen.
FT CHAIN 1..643
FT /note="Melanoma-associated antigen C3"
FT /id="PRO_0000156722"
FT DOMAIN 184..384
FT /note="MAGE 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT DOMAIN 456..643
FT /note="MAGE 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT REGION 347..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..378
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..415
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 478
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18318008"
FT MOD_RES 484
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18318008"
FT MOD_RES 485
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18318008"
FT VAR_SEQ 1..76
FT /note="MLLPCHWVLDATFSDGSLGQWVKNTCATYALSPVVLPPQPQPRKKATDKDYS
FT AFHLGHLREVRLFLRGGTSDQRMD -> MPLFPNLPRLSFEEDFQNPSVTEDLVDAQDS
FT IDEEEEDASSTSSSSFHFLFPSSSSLSSSSPLSSPLPSTLILGVP (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_043489"
FT VAR_SEQ 77..374
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_043490"
FT VAR_SEQ 577..643
FT /note="PIQRPAREVLEFLSKLSSIIPSAFPSWYMDALKDMEDRAQAIIDTTDDATAM
FT ASASPSVMSTNFCPE -> VCAGREHFIYGDPRKLLTIHWVQRKYLEYREVPNSAPPRY
FT EFLWGPRAHSEASKRSLRVFIQAIQYHP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_043491"
FT VARIANT 155
FT /note="S -> P (in dbSNP:rs11095909)"
FT /id="VAR_060069"
FT VARIANT 165
FT /note="L -> M (in dbSNP:rs11095910)"
FT /id="VAR_053505"
FT VARIANT 307
FT /note="A -> T (in dbSNP:rs176024)"
FT /id="VAR_053506"
FT VARIANT 328
FT /note="A -> T (in dbSNP:rs176026)"
FT /id="VAR_053507"
FT CONFLICT 362..374
FT /note="GLTEASPQQKKGG -> SSPLPSTLILGVP (in Ref. 3)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 643 AA; 71909 MW; 4EB342288B3FB8A6 CRC64;
MLLPCHWVLD ATFSDGSLGQ WVKNTCATYA LSPVVLPPQP QPRKKATDKD YSAFHLGHLR
EVRLFLRGGT SDQRMDSLVL CPTYFKLWRT LSGSPGLQLS DLHFGSQPEG KFSLRRAVSV
KQREEPQDWP LNEKRTLWKD SDLPTWRRGT GYTLSLPAVS PGKRLWGEKA GSLPESEPLF
TYTLDEKVDK LVQFLLLKYQ AKEPLTRAEM QMNVINTYTG YFPMIFRKAR EFIEILFGIS
LTEVDPDHFY VFVNTLDLTC EGSLSDEQGM PQNRLLILIL SVIFIKGNCA SEEVIWEVLN
AIGPWSALAG FADVLSRLAL WESEGPEAFC EESGLRSAEG SVLDLANPQG LAGHRQEDGR
RGLTEASPQQ KKGGEDEDMP AAGMPPLPQS PPEIPPQGPP KISPQGPPQS PPQSPLDSCS
SPLLWTRLDE ESSSEEEDTA TWHALPESES LPRYALDEKV AELVQFLLLK YQTKEPVTKA
EMLTTVIKKY KDYFPMIFGK AHEFIELIFG IALTDMDPDN HSYFFEDTLD LTYEGSLIDD
QGMPKNCLLI LILSMIFIKG SCVPEEVIWE VLSAIGPIQR PAREVLEFLS KLSSIIPSAF
PSWYMDALKD MEDRAQAIID TTDDATAMAS ASPSVMSTNF CPE
