ID   5MP1_CHICK              Reviewed;         414 AA.
AC   Q5ZL42;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=eIF5-mimic protein 1 {ECO:0000250|UniProtKB:Q9Y6E2};
DE   AltName: Full=Basic leucine zipper and W2 domain-containing protein 2;
GN   Name=BZW2; Synonyms=5MP1 {ECO:0000250|UniProtKB:Q9Y6E2};
GN   ORFNames=RCJMB04_7o12;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Translation initiation regulator which may repress non-AUG
CC       initiated translation and repeat-associated non-AUG (RAN) initiated
CC       translation by acting as a competitive inhibitor of eukaryotic
CC       translation initiation factor 5 (EIF5) function.
CC       {ECO:0000250|UniProtKB:Q9Y6E2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Y6E2}.
CC   -!- SIMILARITY: Belongs to the BZW family. {ECO:0000305}.
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DR   EMBL; AJ719892; CAG31551.1; -; mRNA.
DR   RefSeq; NP_001006358.2; NM_001006358.2.
DR   AlphaFoldDB; Q5ZL42; -.
DR   BioGRID; 681535; 1.
DR   STRING; 9031.ENSGALP00000017553; -.
DR   PaxDb; Q5ZL42; -.
DR   GeneID; 420594; -.
DR   KEGG; gga:420594; -.
DR   CTD; 28969; -.
DR   VEuPathDB; HostDB:geneid_420594; -.
DR   eggNOG; KOG2297; Eukaryota.
DR   InParanoid; Q5ZL42; -.
DR   OrthoDB; 653740at2759; -.
DR   PhylomeDB; Q5ZL42; -.
DR   PRO; PR:Q5ZL42; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0006446; P:regulation of translational initiation; ISS:UniProtKB.
DR   CDD; cd11560; W2_eIF5C_like; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR043510; W2_BZW1/2.
DR   InterPro; IPR003307; W2_domain.
DR   Pfam; PF02020; W2; 1.
DR   SMART; SM00515; eIF5C; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS51363; W2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Translation regulation.
FT   CHAIN           1..414
FT                   /note="eIF5-mimic protein 1"
FT                   /id="PRO_0000254623"
FT   DOMAIN          248..414
FT                   /note="W2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00695"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   414 AA;  47842 MW;  780C1E6F5BDCCB87 CRC64;
     MNKNQKPVLT GQRFKTRKRD EKEKFEPTVF RDTIVQGLNE AGSDLEAIAK FLDSAGSRLD
     YRRYADTLFD ILVAGSMLAP GGTRIDDNDK TKMTRHCVFF AEEDHDAIRN YAQVFNKLIR
     RYKYLEKAFE DEIKKLLLFL KAFSETEQTK LAMLSGILLA NGTLPATILT SLFTDNIVKE
     GIAASFAVKL FKAWMAEKDA NSVTSALRKA NLDKRLLELF PANRQNVDHF AKYFTEAGLK
     ELSDFLRVQQ SLGTRKELQK ELQERLSQEC PIKEMVLYVK EEMKRNELPE PAVIGLLWTC
     VMNAVEWNKK EELVAEQALK HLKQYAPLLA VFSTQGQSEL ILLQKVQEYC YDNIHFMKAF
     QKIVVLFYKA DVLSEEAILK WYKEAHVAKG KSVFLDQMKK FVEWLQNAEE EFRI