ID   LTOR2_TAEGU             Reviewed;         125 AA.
AC   B5FYY5;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Ragulator complex protein LAMTOR2;
DE   AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2;
GN   Name=LAMTOR2;
OS   Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC   Estrildinae; Taeniopygia.
OX   NCBI_TaxID=59729;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=17018643; DOI=10.1073/pnas.0607098103;
RA   Wada K., Howard J.T., McConnell P., Whitney O., Lints T., Rivas M.V.,
RA   Horita H., Patterson M.A., White S.A., Scharff C., Haesler S., Zhao S.,
RA   Sakaguchi H., Hagiwara M., Shiraki T., Hirozane-Kishikawa T., Skene P.,
RA   Hayashizaki Y., Carninci P., Jarvis E.D.;
RT   "A molecular neuroethological approach for identifying and characterizing a
RT   cascade of behaviorally regulated genes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15212-15217(2006).
CC   -!- FUNCTION: Regulator of the TOR pathway, a signaling cascade that
CC       promotes cell growth in response to growth factors, energy levels, and
CC       amino acids. As part of the Ragulator complex, may activate the TOR
CC       signaling cascade in response to amino acids. Adapter protein that may
CC       regulate the MAP kinase cascade (By similarity).
CC       {ECO:0000250|UniProtKB:Q9Y2Q5}.
CC   -!- SUBUNIT: Part of the Ragulator complex composed of lamtor1, lamtor2,
CC       lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with
CC       slc38a9; the probable amino acid sensor. Component of the lysosomal
CC       folliculin complex (LFC). {ECO:0000250|UniProtKB:Q9Y2Q5}.
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC       Lysosome membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GAMAD family. {ECO:0000305}.
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DR   EMBL; DQ214220; ACH44246.1; -; mRNA.
DR   EMBL; DQ214221; ACH44247.1; -; mRNA.
DR   RefSeq; NP_001232058.1; NM_001245129.1.
DR   AlphaFoldDB; B5FYY5; -.
DR   SMR; B5FYY5; -.
DR   STRING; 59729.ENSTGUP00000003776; -.
DR   Ensembl; ENSTGUT00000003818; ENSTGUP00000003776; ENSTGUG00000003670.
DR   GeneID; 100190214; -.
DR   KEGG; tgu:100190214; -.
DR   CTD; 28956; -.
DR   GeneTree; ENSGT00390000006100; -.
DR   InParanoid; B5FYY5; -.
DR   OrthoDB; 1515483at2759; -.
DR   Proteomes; UP000007754; Chromosome 25.
DR   GO; GO:0005770; C:late endosome; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0071986; C:Ragulator complex; ISS:UniProtKB.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR   GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR   GO; GO:0010761; P:fibroblast migration; IEA:Ensembl.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR   GO; GO:1902414; P:protein localization to cell junction; IEA:Ensembl.
DR   GO; GO:0001558; P:regulation of cell growth; ISS:UniProtKB.
DR   GO; GO:0150116; P:regulation of cell-substrate junction organization; IEA:Ensembl.
DR   InterPro; IPR037587; LAMTOR2-like.
DR   InterPro; IPR004942; Roadblock/LAMTOR2_dom.
DR   PANTHER; PTHR13323; PTHR13323; 1.
DR   Pfam; PF03259; Robl_LC7; 1.
DR   SMART; SM00960; Robl_LC7; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Lysosome; Membrane; Reference proteome.
FT   CHAIN           1..125
FT                   /note="Ragulator complex protein LAMTOR2"
FT                   /id="PRO_0000365940"
FT   REGION          57..70
FT                   /note="Required for location at endosomes"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   125 AA;  13531 MW;  4877209ACB5BD705 CRC64;
     MLRPKALTQV LSQANTGGVQ STLLLNNEGS LLAYSGYGDT DARVTAAIAS NIWVAYDKNG
     HQAFNEDNLK FILMDCMEGR VAITRVANLL LCMYAKETVG FGMLKAKAQA LVQYLEEPLT
     QVAAS