ID   LTOR2_DANRE             Reviewed;         125 AA.
AC   Q6DEG4;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Ragulator complex protein LAMTOR2;
DE   AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2;
GN   Name=lamtor2; ORFNames=zgc:100811;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of the TOR pathway, a signaling cascade that
CC       promotes cell growth in response to growth factors, energy levels, and
CC       amino acids. As part of the Ragulator complex, may activate the TOR
CC       signaling cascade in response to amino acids. Adapter protein that may
CC       regulate the MAP kinase cascade (By similarity).
CC       {ECO:0000250|UniProtKB:Q9Y2Q5}.
CC   -!- SUBUNIT: Part of the Ragulator complex composed of lamtor1, lamtor2,
CC       lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with
CC       slc38a9; the probable amino acid sensor. Component of the lysosomal
CC       folliculin complex (LFC). {ECO:0000250|UniProtKB:Q9Y2Q5}.
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC       Lysosome membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GAMAD family. {ECO:0000305}.
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DR   EMBL; BC077153; AAH77153.1; -; mRNA.
DR   AlphaFoldDB; Q6DEG4; -.
DR   SMR; Q6DEG4; -.
DR   STRING; 7955.ENSDARP00000058324; -.
DR   PaxDb; Q6DEG4; -.
DR   ZFIN; ZDB-GENE-040801-63; lamtor2.
DR   eggNOG; KOG4107; Eukaryota.
DR   InParanoid; Q6DEG4; -.
DR   PhylomeDB; Q6DEG4; -.
DR   Reactome; R-DRE-1632852; Macroautophagy.
DR   Reactome; R-DRE-165159; MTOR signalling.
DR   Reactome; R-DRE-166208; mTORC1-mediated signalling.
DR   Reactome; R-DRE-380972; Energy dependent regulation of mTOR by LKB1-AMPK.
DR   Reactome; R-DRE-5628897; TP53 Regulates Metabolic Genes.
DR   Reactome; R-DRE-5674135; MAP2K and MAPK activation.
DR   Reactome; R-DRE-6798695; Neutrophil degranulation.
DR   Reactome; R-DRE-8943724; Regulation of PTEN gene transcription.
DR   Reactome; R-DRE-9639288; Amino acids regulate mTORC1.
DR   PRO; PR:Q6DEG4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005770; C:late endosome; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0071986; C:Ragulator complex; ISS:UniProtKB.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR   GO; GO:0001558; P:regulation of cell growth; ISS:UniProtKB.
DR   InterPro; IPR037587; LAMTOR2-like.
DR   InterPro; IPR004942; Roadblock/LAMTOR2_dom.
DR   PANTHER; PTHR13323; PTHR13323; 1.
DR   Pfam; PF03259; Robl_LC7; 1.
DR   SMART; SM00960; Robl_LC7; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Lysosome; Membrane; Reference proteome.
FT   CHAIN           1..125
FT                   /note="Ragulator complex protein LAMTOR2"
FT                   /id="PRO_0000240661"
FT   REGION          57..70
FT                   /note="Required for location at endosomes"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   125 AA;  13578 MW;  5B23F1C5815AD71A CRC64;
     MLRPKALTQV LSQANTSGVQ STLLLNNEGS LLTYSGYGDT DARVTAAIAS NIWAAYDKNG
     HQAFNEDKLK FILMDCMEGR VAITRVANLL LCMYAKETVG FGMLKAKAEA LVQYLEEPLT
     QVAAS