ID   LTOR2_CAEEL             Reviewed;         124 AA.
AC   Q9N2U6;
DT   24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Ragulator complex protein LAMTOR2 homolog {ECO:0000250|UniProtKB:Q9Y2Q5};
DE   AltName: Full=Late endosomal/lysosomal adapter and MAPK and MTOR activator 1 {ECO:0000312|WormBase:Y97E10AR.7};
GN   Name=lmtr-2 {ECO:0000312|WormBase:Y97E10AR.7};
GN   ORFNames=Y97E10AR.7 {ECO:0000312|WormBase:Y97E10AR.7};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Regulator of the TOR pathway, a signaling cascade that
CC       promotes cell growth in response to growth factors, energy levels, and
CC       amino acids. May activate the TOR signaling cascade in response to
CC       amino acids. {ECO:0000250|UniProtKB:Q9Y2Q5}.
CC   -!- SUBUNIT: Part of the Ragulator complex. {ECO:0000250|UniProtKB:Q9Y2Q5}.
CC   -!- SIMILARITY: Belongs to the GAMAD family. {ECO:0000305}.
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DR   EMBL; FO081378; CCD71184.1; -; Genomic_DNA.
DR   RefSeq; NP_505061.1; NM_072660.5.
DR   AlphaFoldDB; Q9N2U6; -.
DR   SMR; Q9N2U6; -.
DR   BioGRID; 44219; 5.
DR   IntAct; Q9N2U6; 2.
DR   STRING; 6239.Y97E10AR.7.2; -.
DR   EPD; Q9N2U6; -.
DR   PaxDb; Q9N2U6; -.
DR   PeptideAtlas; Q9N2U6; -.
DR   EnsemblMetazoa; Y97E10AR.7.1; Y97E10AR.7.1; WBGene00022402.
DR   GeneID; 179177; -.
DR   KEGG; cel:CELE_Y97E10AR.7; -.
DR   UCSC; Y97E10AR.7.2; c. elegans.
DR   CTD; 179177; -.
DR   WormBase; Y97E10AR.7; CE25642; WBGene00022402; lmtr-2.
DR   eggNOG; KOG4107; Eukaryota.
DR   GeneTree; ENSGT00390000006100; -.
DR   HOGENOM; CLU_141118_0_0_1; -.
DR   InParanoid; Q9N2U6; -.
DR   OMA; MVRAKLH; -.
DR   OrthoDB; 1515483at2759; -.
DR   PhylomeDB; Q9N2U6; -.
DR   Reactome; R-CEL-1632852; Macroautophagy.
DR   Reactome; R-CEL-165159; MTOR signalling.
DR   Reactome; R-CEL-166208; mTORC1-mediated signalling.
DR   Reactome; R-CEL-380972; Energy dependent regulation of mTOR by LKB1-AMPK.
DR   Reactome; R-CEL-5628897; TP53 Regulates Metabolic Genes.
DR   Reactome; R-CEL-5674135; MAP2K and MAPK activation.
DR   Reactome; R-CEL-6798695; Neutrophil degranulation.
DR   Reactome; R-CEL-8943724; Regulation of PTEN gene transcription.
DR   Reactome; R-CEL-9639288; Amino acids regulate mTORC1.
DR   PRO; PR:Q9N2U6; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00022402; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0071986; C:Ragulator complex; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR   GO; GO:0001558; P:regulation of cell growth; ISS:UniProtKB.
DR   InterPro; IPR037587; LAMTOR2-like.
DR   InterPro; IPR004942; Roadblock/LAMTOR2_dom.
DR   PANTHER; PTHR13323; PTHR13323; 1.
DR   Pfam; PF03259; Robl_LC7; 1.
DR   SMART; SM00960; Robl_LC7; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..124
FT                   /note="Ragulator complex protein LAMTOR2 homolog"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000220962"
SQ   SEQUENCE   124 AA;  13188 MW;  AA4585E1C15C4532 CRC64;
     MLKQKALVDV LGQVNTSGVD GSWLFNKEGL LLAYVGSEQK AVASNVSSAL IASVWAALER
     RANDLKETIL VLENGVIGCT LVARTMLLAV KADKSADLGM VRAKLHTLAA YLEQPILSIS
     HDLG