ID   LSRB_SALPA              Reviewed;         340 AA.
AC   Q5PJE4;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Autoinducer 2-binding protein LsrB;
DE            Short=AI-2-binding protein LsrB;
DE   Flags: Precursor;
GN   Name=lsrB; OrderedLocusNames=SPA3920;
OS   Salmonella paratyphi A (strain ATCC 9150 / SARB42).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=295319;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 9150 / SARB42;
RX   PubMed=15531882; DOI=10.1038/ng1470;
RA   McClelland M., Sanderson K.E., Clifton S.W., Latreille P., Porwollik S.,
RA   Sabo A., Meyer R., Bieri T., Ozersky P., McLellan M., Harkins C.R.,
RA   Wang C., Nguyen C., Berghoff A., Elliott G., Kohlberg S., Strong C., Du F.,
RA   Carter J., Kremizki C., Layman D., Leonard S., Sun H., Fulton L., Nash W.,
RA   Miner T., Minx P., Delehaunty K., Fronick C., Magrini V., Nhan M.,
RA   Warren W., Florea L., Spieth J., Wilson R.K.;
RT   "Comparison of genome degradation in Paratyphi A and Typhi, human-
RT   restricted serovars of Salmonella enterica that cause typhoid.";
RL   Nat. Genet. 36:1268-1274(2004).
CC   -!- FUNCTION: Part of the ABC transporter complex LsrABCD involved in
CC       autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and
CC       LsrD permeases (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (LsrA),
CC       two transmembrane proteins (LsrC and LsrD) and a solute-binding protein
CC       (LsrB). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 2 family.
CC       {ECO:0000305}.
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DR   EMBL; CP000026; AAV79685.1; -; Genomic_DNA.
DR   RefSeq; WP_000090734.1; NC_006511.1.
DR   AlphaFoldDB; Q5PJE4; -.
DR   SMR; Q5PJE4; -.
DR   EnsemblBacteria; AAV79685; AAV79685; SPA3920.
DR   KEGG; spt:SPA3920; -.
DR   HOGENOM; CLU_037628_3_0_6; -.
DR   OMA; KQVNNPY; -.
DR   Proteomes; UP000008185; Chromosome.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:UniProt.
DR   CDD; cd20003; PBP1_LsrB_Quorum_Sensing; 1.
DR   InterPro; IPR030159; LsrB.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR025997; SBP_2_dom.
DR   PANTHER; PTHR46847:SF4; PTHR46847:SF4; 1.
DR   Pfam; PF13407; Peripla_BP_4; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
PE   3: Inferred from homology;
KW   Periplasm; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..340
FT                   /note="Autoinducer 2-binding protein LsrB"
FT                   /id="PRO_0000351327"
SQ   SEQUENCE   340 AA;  36832 MW;  78FDD62C3B68B984 CRC64;
     MARHSIKMIA LLTAFGLASA AMTVQAAERI AFIPKLVGVG FFTSGGNGAQ EAGKALGIDV
     TYDGPTEPSV SGQVQLVNNF VNQEYDAIIV SAVSPDGLCP ALKRAMQRGV KILTWDSDTK
     PECRSYYINQ GTPKQLGSML VEMAAHQVDK EKAKVAFFYS SPTVTDQNQW VKEAKAKISQ
     EHPGWEIVTT QFGYNDATKS LQTAEGIIKA YPDLDAIIAP DANALPAAAQ AAENLKRNNL
     AIVGFSTPNV MRPYVQRGTV KEFGLWDVVQ QGKISVYVAN ALLKNMPMNV GDSLDIPGIG
     KVTVSPNSEQ GYHYEAKGNG IVLLPERVIF NKDNIDKYDF