LRR3C_HUMAN
ID LRR3C_HUMAN Reviewed; 275 AA.
AC A6NJW4;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Leucine-rich repeat-containing protein 3C;
DE Flags: Precursor;
GN Name=LRRC3C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-117.
RA Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.;
RT "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in
RT human.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the LRRC3 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAW60623.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC090844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471152; EAW60623.1; ALT_SEQ; Genomic_DNA.
DR EMBL; DY655553; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS54121.1; -.
DR RefSeq; NP_001182474.1; NM_001195545.1.
DR RefSeq; XP_011522460.1; XM_011524158.2.
DR RefSeq; XP_016879492.1; XM_017024003.1.
DR AlphaFoldDB; A6NJW4; -.
DR SMR; A6NJW4; -.
DR BioGRID; 611008; 1.
DR IntAct; A6NJW4; 1.
DR STRING; 9606.ENSP00000367157; -.
DR GlyGen; A6NJW4; 1 site.
DR iPTMnet; A6NJW4; -.
DR PhosphoSitePlus; A6NJW4; -.
DR BioMuta; LRRC3C; -.
DR PaxDb; A6NJW4; -.
DR PeptideAtlas; A6NJW4; -.
DR PRIDE; A6NJW4; -.
DR Antibodypedia; 71102; 61 antibodies from 14 providers.
DR DNASU; 100505591; -.
DR Ensembl; ENST00000377924.6; ENSP00000367157.4; ENSG00000204913.7.
DR GeneID; 100505591; -.
DR KEGG; hsa:100505591; -.
DR MANE-Select; ENST00000377924.6; ENSP00000367157.4; NM_001195545.2; NP_001182474.1.
DR UCSC; uc021twv.2; human.
DR CTD; 100505591; -.
DR DisGeNET; 100505591; -.
DR GeneCards; LRRC3C; -.
DR HGNC; HGNC:40034; LRRC3C.
DR HPA; ENSG00000204913; Not detected.
DR neXtProt; NX_A6NJW4; -.
DR OpenTargets; ENSG00000204913; -.
DR VEuPathDB; HostDB:ENSG00000204913; -.
DR eggNOG; KOG4237; Eukaryota.
DR GeneTree; ENSGT00940000154360; -.
DR HOGENOM; CLU_064640_1_0_1; -.
DR InParanoid; A6NJW4; -.
DR OMA; HYMWQNR; -.
DR OrthoDB; 1056523at2759; -.
DR PhylomeDB; A6NJW4; -.
DR TreeFam; TF334047; -.
DR PathwayCommons; A6NJW4; -.
DR SignaLink; A6NJW4; -.
DR BioGRID-ORCS; 100505591; 23 hits in 1065 CRISPR screens.
DR ChiTaRS; LRRC3C; human.
DR GenomeRNAi; 100505591; -.
DR Pharos; A6NJW4; Tdark.
DR PRO; PR:A6NJW4; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; A6NJW4; protein.
DR Bgee; ENSG00000204913; Expressed in apex of heart and 24 other tissues.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 3.
DR PROSITE; PS51450; LRR; 3.
PE 2: Evidence at transcript level;
KW Glycoprotein; Leucine-rich repeat; Membrane; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..41
FT /evidence="ECO:0000255"
FT CHAIN 42..275
FT /note="Leucine-rich repeat-containing protein 3C"
FT /id="PRO_0000345962"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 42..79
FT /note="LRRNT"
FT REPEAT 80..101
FT /note="LRR 1"
FT REPEAT 104..125
FT /note="LRR 2"
FT REPEAT 129..150
FT /note="LRR 3"
FT DOMAIN 160..212
FT /note="LRRCT"
FT CARBOHYD 156
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 275 AA; 29314 MW; 0C09514F5D8CB9E7 CRC64;
MRMTSSSFVS YCTPGLCQFM AMLPTAGHLL PLLLVIGTGG TVPSPQVPPR GCYVAKEAGE
RTFRCSQAGL SAVPSGIPND TRKLYLDANQ LASVPAGAFQ HLPVLEELDL SHNALAHLSG
AAFQGLEGTL RHLDLSANQL ASVPVEAFVG LQIQVNLSAN PWHCDCALQE VLRQVRLVPG
TGTGIVCGSG ARPDLVGQEF LLLAGEEELC GSGWGGARRS TDVALLVTMG GWLTLMVAYL
VHYVWQNRDE TRRSLKRAPV LPVRSEDSSI LSTVV
