LRR2_PLAF7
ID LRR2_PLAF7 Reviewed; 2752 AA.
AC C6KSS5;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-SEP-2009, sequence version 1.
DT 25-MAY-2022, entry version 52.
DE RecName: Full=Protein PFF0380w;
GN ORFNames=PFF0380w;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [3]
RP SYNTHESIS OF 1734-1768, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT "Rapid identification of malaria vaccine candidates based on alpha-helical
RT coiled coil protein motif.";
RL PLoS ONE 2:E645-E645(2007).
CC -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC determined by epitope response in sera.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL844505; CAG25247.1; -; Genomic_DNA.
DR RefSeq; XP_966067.1; XM_960974.1.
DR SMR; C6KSS5; -.
DR STRING; 5833.PFF0380w; -.
DR SwissPalm; C6KSS5; -.
DR PRIDE; C6KSS5; -.
DR EnsemblProtists; CAG25247; CAG25247; PF3D7_0607700.
DR GeneID; 3885834; -.
DR KEGG; pfa:PF3D7_0607700; -.
DR VEuPathDB; PlasmoDB:PF3D7_0607700; -.
DR HOGENOM; CLU_227057_0_0_1; -.
DR InParanoid; C6KSS5; -.
DR OMA; DMKEDTP; -.
DR Proteomes; UP000001450; Chromosome 6.
DR InterPro; IPR025677; OST-HTH-assoc_dom.
DR InterPro; IPR025605; OST-HTH/LOTUS_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR Pfam; PF14418; OHA; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
DR PROSITE; PS51644; HTH_OST; 1.
PE 1: Evidence at protein level;
KW Merozoite; Reference proteome; Repeat.
FT CHAIN 1..2752
FT /note="Protein PFF0380w"
FT /id="PRO_0000370736"
FT DOMAIN 1277..1354
FT /note="HTH OST-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT REGION 20..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1048..1130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1153..1172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1457..1499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1958..1999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2063..2099
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2501..2537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1048..1062
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1063..1130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1465..1499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1959..1973
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1974..1995
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2068..2098
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2752 AA; 325017 MW; 44539CDE80FF6F4F CRC64;
MVFEKENKTC MKDVRYDLQE REKEEEEKKR NYNISNNNNN NNYNKYDKNY ISHVADYINR
KQINNMNDNN MNKSCIMKRF NKKDVKYNDM LLKADETYIN DGQIKKKYNN NNNNNNNNTK
SIYLTNTYNK SSSIHNKPHI HKNNDINNIH EKNDKSNNDY NYSHNNISFD YNVEPVYNYI
NEGHNPDISL NKMEIQKGTY NNYCYENFIV NDDVDSYRDT HENNIMLLDD ENNNSIFIKK
NKSSFYHTSQ HNNQGFINTN DTIKRNKNFV LQKNDINLTN DKINSSFNKK KNKLTSIYVE
REDQKVGPLN VNNDMSILNK KKESKHNFYK SMNEHDVIAE KKKNTILKNK CVEDDNIRTI
ENVHNDSLKN EHMNDIYMKD NNNNINTYKI VHDKPLSAVE NLQEVNKKKN YKNVIFKHLF
NNDKDDNVYN LKKNKNNDVV EFNMNKKMTL ISGNKMYKNE TAKMYNSNQE IYISNNNNDN
NNDNNNDNNI NNYHHGYKKY NTTNQYNNNN NNNNNSNIYP FYKNTSINNC NNKKINEYDN
NLFNNKKDIL NNTNFVKSQD YHDNKNIQYN INSNDNYYHS FGDIKNEGNM NTMFNVKKKY
KKVRINSHIS SKLNDKSIIN YRNGVINNQF NHMNDIVSSN NNNNNNNNNN NNNNNNNNNN
NNNNNNNNNN NNNNINMKTS ICNNKKRKNT KNFSLNLCSA CLNIDDKIYI KQIKEILDRD
INLLNEDPRI INALKKSHIS TSYLFNNLKS LGTFRKGGLT WAIYYNNNNK GVNNMIKIKN
EANNRIVKDK LLNNMNCTNI MNDIKNINTL ATNNGGGYNL NNVNNMSNIY NVVDAKNGNH
MNNRKDMSIN TDCFNYTNSI DEMDDINENN KKKDNFPFLN NSNIDSDNNY IELIKNNSFC
NDKYIIEPII ENTWLKKVLL IIKKESLDIE CFLFKIKYYF YKSVLFLYQE GIKSYLGDVA
NQMKIYINYN FWSAAEIAFI LRQITSLCNI QIEVRVKGEI GCVIYLNEEP EWFQGFVDSH
NLNDTFSKKD WYLLNNFAIK MMQYRKGDKK SEDMKEDTPT RGENLQRGQN LQRGDNLQRG
DNLQRGDNLQ RGDNLQNGDN LQNGDNLQRG DNLQNGENLQ SGENLQSGEN LQSGENLQTR
ENLQSGENLQ TRENLQSDEN HNNILYPYNN NGQYEDNYNN SYNNNNNECI FCSSSNKKLK
SYMFNGGRYA FAAKLKEEIK HFHSKRLGDI IHLVQLAIHK GIFVYSQRIL LPVSACEKSA
DDLYPKIRNL NYDICETLEE VLEIISLLVD HKTNGLVLAQ LKQQFILQFK KELNSLHFGY
KKLQNLLMAE PFNKYYKLYI PNNNLHRTHI QHKKYKTPDN CRIFQKENIH LKNHLDFIYN
TEFFTELYVE DEYYDNEDTK QSIQPIYDNI ISTSCNNHIQ QQNGSLYMSN TTFRNDKEEI
KKDIYLLNIR DSQNKRDIKQ DNISKKKINN INSNNSNNSN SNSNSNNNNN NNYNSNNISD
NKLELTYQNI HNLPSYIQKS IETIFEKNNK ENDKSKWIEE EEEEKEECPL KEINKNIQHN
KNYDYIINNN IFQNRGSNNI QSYDDRNQNK QIQFLNTLYH IDVELSPVNT KRYNKIKDIF
TNMIKINKKC NDNIINNDDI IKNDHDEFIN DDQHYNIWNV HFEKRTLLNR YKQDNTTGAT
NVVSPILNIY TLIKKYKIKK KKYESFFDDI NNDVDIHVNN KTEQNKDNGH IENNNINNIN
NNINNINNNI NNINNNINNI NNNVNNYYYI DNGDGNNIHK GYINNYIIPE DNPIHNNFTY
DNNKKNTTKQ TLQLLHNTEI NFIPDIDPID VTNVNINRKN KMNKIYKTKN VINRHHTNKS
METFEPNNKL DSYEDRNIQF YNENCNRYMN ADYKTGQSTL PILSGTTNNI RYKTGESTLP
ILSGTTNNTR YKTGESTLPI LSGTTNNTRY KTERFFKAKN SNQENINQNE INYNNNDDDD
DNNNNNNDDD DDDNNYYMLN NQYGDNIMTE SNYISSHNNL PQEDIFNDEK KIIEMIEKTI
DQDYINIEDK NDVKHDMIKK INKRKNNNIH NYNDNNNDNN NDNNNDNNND NNNDNNNDKY
FIFDKDINNN VDENNINNIH LKDNIKKKKE KNEYNNYKIS SYNNNDGDNY GDNNNNLINN
SIYYYDSSKN RSIKYGDEYE EEIYNTKNVI NQKNYGNINN YDYNVIFTNI AQVNDENLYI
PNSRSINIDI NDTDNNNCVK NITYINNNSN PLESNNNGST TTTTTTTSIK NNMKHYNVDI
NNLDDIKDIY MYNSNNNDST NVERDNNNIN IEHVGEKPFC YYTHNYNNNV SNINFNTFNP
SLNLIMNNPK KNNDQNSIFK KEQYSSYEPV KNNDINIFYS NKYDNNSNYI YEQKIKKNEN
DVIYKNDDKI FSNLNKSEEC VHSSNSFVNN LYIPYNNMKD KDNIMSPQNN IIYDEQINNI
NNFTLNNHNM NNGHNIGDEY SDESYEIRHI NNINKKDNLM DENNILNNNN DNNNNNNDKS
NLVLHNNNDK SNHFLHNNNN DSYNYDIYNH FHTYNNCNLY NDDKNELSKK GAVLNRYNEQ
EQNIPIEHEY NNISYPSLIK NNKNNSEKKY LDNLSINLKD EKNYHPEKKN FNNNLEKNNK
IFTNDIEHIS FNKKICKIKN IYSENKNNQF FKNNTNHLFN TNINLYEKKN YVDDEFSHHK
DPIKFSSLIK NKQNNNNSFM NLLNDNQYVK INNQNTFNNP NKYHHMKNKI NK
