LOR15_ARATH
ID LOR15_ARATH Reviewed; 217 AA.
AC Q9LZX1; Q8LEK9;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Protein LURP-one-related 15;
GN OrderedLocusNames=At5g01750; ORFNames=T20L15.20;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA Brover V., Troukhan M., Alexandrov N., Lu Y.-P., Flavell R., Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION.
RX PubMed=19010806; DOI=10.1093/bioinformatics/btn595;
RA Bateman A., Finn R.D., Sims P.J., Wiedmer T., Biegert A., Soding J.;
RT "Phospholipid scramblases and Tubby-like proteins belong to a new
RT superfamily of membrane tethered transcription factors.";
RL Bioinformatics 25:159-162(2009).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22223895; DOI=10.1074/mcp.m111.015131;
RA Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T.,
RA Giglione C.;
RT "Comparative large-scale characterisation of plant vs. mammal proteins
RT reveals similar and idiosyncratic N-alpha acetylation features.";
RL Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
RN [7]
RP X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 1-217 (ISOFORM 1).
RG Center for eukaryotic structural genomics (CESG);
RT "X-ray structure of protein At5g01750 from Arabidopsis thaliana.";
RL Submitted (JUN-2005) to the PDB data bank.
CC -!- FUNCTION: Might be related to the phospholipid scramblase and tubby-
CC like superfamily of membrane tethered transcription factors.
CC {ECO:0000269|PubMed:19010806}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9LZX1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9LZX1-2; Sequence=VSP_018603, VSP_018604;
CC -!- SIMILARITY: Belongs to the LOR family. {ECO:0000305}.
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DR EMBL; AL162351; CAB82745.1; -; Genomic_DNA.
DR EMBL; CP002688; AED90386.1; -; Genomic_DNA.
DR EMBL; CP002688; AED90387.1; -; Genomic_DNA.
DR EMBL; AF372877; AAK49593.1; -; mRNA.
DR EMBL; AY142034; AAM98298.1; -; mRNA.
DR EMBL; AY085369; AAM62599.1; -; mRNA.
DR PIR; T48196; T48196.
DR RefSeq; NP_568095.1; NM_120253.4. [Q9LZX1-2]
DR RefSeq; NP_850751.1; NM_180420.2. [Q9LZX1-1]
DR PDB; 1ZXU; X-ray; 1.70 A; A=1-217.
DR PDB; 2Q4M; X-ray; 1.70 A; A=1-217.
DR PDBsum; 1ZXU; -.
DR PDBsum; 2Q4M; -.
DR AlphaFoldDB; Q9LZX1; -.
DR SMR; Q9LZX1; -.
DR BioGRID; 16960; 5.
DR IntAct; Q9LZX1; 4.
DR STRING; 3702.AT5G01750.2; -.
DR iPTMnet; Q9LZX1; -.
DR PaxDb; Q9LZX1; -.
DR PRIDE; Q9LZX1; -.
DR ProteomicsDB; 238665; -. [Q9LZX1-1]
DR DNASU; 831684; -.
DR EnsemblPlants; AT5G01750.1; AT5G01750.1; AT5G01750. [Q9LZX1-2]
DR EnsemblPlants; AT5G01750.2; AT5G01750.2; AT5G01750. [Q9LZX1-1]
DR GeneID; 831684; -.
DR Gramene; AT5G01750.1; AT5G01750.1; AT5G01750. [Q9LZX1-2]
DR Gramene; AT5G01750.2; AT5G01750.2; AT5G01750. [Q9LZX1-1]
DR KEGG; ath:AT5G01750; -.
DR Araport; AT5G01750; -.
DR TAIR; locus:2181082; AT5G01750.
DR eggNOG; ENOG502QUU9; Eukaryota.
DR HOGENOM; CLU_063146_5_1_1; -.
DR InParanoid; Q9LZX1; -.
DR OMA; LAGNTKQ; -.
DR OrthoDB; 1135595at2759; -.
DR PhylomeDB; Q9LZX1; -.
DR EvolutionaryTrace; Q9LZX1; -.
DR PRO; PR:Q9LZX1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LZX1; baseline and differential.
DR Genevisible; Q9LZX1; AT.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0019904; F:protein domain specific binding; IPI:CAFA.
DR Gene3D; 2.40.160.200; -; 1.
DR InterPro; IPR007612; LOR.
DR InterPro; IPR038595; LOR_sf.
DR InterPro; IPR025659; Tubby-like_C.
DR PANTHER; PTHR31087; PTHR31087; 1.
DR Pfam; PF04525; LOR; 1.
DR SUPFAM; SSF54518; SSF54518; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Alternative splicing; Reference proteome.
FT CHAIN 1..217
FT /note="Protein LURP-one-related 15"
FT /id="PRO_0000238457"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:22223895"
FT VAR_SEQ 171..174
FT /note="MHRK -> VYYL (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_018603"
FT VAR_SEQ 175..217
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_018604"
FT CONFLICT 31
FT /note="K -> R (in Ref. 4; AAM62599)"
FT /evidence="ECO:0000305"
FT CONFLICT 111
FT /note="D -> E (in Ref. 4; AAM62599)"
FT /evidence="ECO:0000305"
FT HELIX 30..32
FT /evidence="ECO:0007829|PDB:1ZXU"
FT STRAND 38..43
FT /evidence="ECO:0007829|PDB:1ZXU"
FT STRAND 54..58
FT /evidence="ECO:0007829|PDB:1ZXU"
FT STRAND 63..68
FT /evidence="ECO:0007829|PDB:1ZXU"
FT STRAND 76..81
FT /evidence="ECO:0007829|PDB:1ZXU"
FT STRAND 87..92
FT /evidence="ECO:0007829|PDB:1ZXU"
FT STRAND 101..106
FT /evidence="ECO:0007829|PDB:1ZXU"
FT HELIX 112..114
FT /evidence="ECO:0007829|PDB:1ZXU"
FT STRAND 115..120
FT /evidence="ECO:0007829|PDB:1ZXU"
FT STRAND 131..135
FT /evidence="ECO:0007829|PDB:1ZXU"
FT STRAND 145..150
FT /evidence="ECO:0007829|PDB:1ZXU"
FT TURN 152..155
FT /evidence="ECO:0007829|PDB:1ZXU"
FT STRAND 158..161
FT /evidence="ECO:0007829|PDB:1ZXU"
FT TURN 162..164
FT /evidence="ECO:0007829|PDB:1ZXU"
FT STRAND 167..173
FT /evidence="ECO:0007829|PDB:1ZXU"
FT STRAND 186..191
FT /evidence="ECO:0007829|PDB:1ZXU"
FT HELIX 197..211
FT /evidence="ECO:0007829|PDB:1ZXU"
SQ SEQUENCE 217 AA; 24295 MW; 0BC7DEF871177CD3 CRC64;
MEQPYVYAYP QGSGPSGAPT PQAGGVVVDP KYCAPYPIDM AIVRKMMSLT DGNFVITDVN
GNLLFKVKEP VFGLHDKRVL LDGSGTPVVT LREKMVSMHD RWQVFRGGST DQRDLLYTVK
RSSMLQLKTK LDVFLGHNKD EKRCDFRVKG SWLERSCVVY AGESDAIVAQ MHRKHTVQSV
FLGKDNFSVT VYPNVDYAFI ASLVVILDDV NREDRAA
