ARG33_HUMAN
ID ARG33_HUMAN Reviewed; 844 AA.
AC A8MVX0; J3KPX2;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-JUL-2010, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Rho guanine nucleotide exchange factor 33;
GN Name=ARHGEF33;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-83 (ISOFORM 1/2).
RA Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.;
RT "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in
RT human.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 747-844 (ISOFORM 2).
RC TISSUE=Caudate nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- FUNCTION: May act as a guanine-nucleotide releasing factor.
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A8MVX0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A8MVX0-2; Sequence=VSP_044905;
CC -!- SEQUENCE CAUTION:
CC Sequence=DV080278; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AC018693; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC019171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DV080278; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK123375; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS46263.2; -. [A8MVX0-2]
DR RefSeq; NP_001138923.2; NM_001145451.2. [A8MVX0-2]
DR AlphaFoldDB; A8MVX0; -.
DR SMR; A8MVX0; -.
DR BioGRID; 938496; 4.
DR STRING; 9606.ENSP00000387020; -.
DR iPTMnet; A8MVX0; -.
DR PhosphoSitePlus; A8MVX0; -.
DR BioMuta; ARHGEF33; -.
DR MassIVE; A8MVX0; -.
DR PaxDb; A8MVX0; -.
DR PeptideAtlas; A8MVX0; -.
DR PRIDE; A8MVX0; -.
DR ProteomicsDB; 2212; -. [A8MVX0-1]
DR Antibodypedia; 49385; 58 antibodies from 12 providers.
DR DNASU; 100271715; -.
DR Ensembl; ENST00000398800.8; ENSP00000381780.4; ENSG00000214694.12. [A8MVX0-2]
DR Ensembl; ENST00000409978.7; ENSP00000387020.1; ENSG00000214694.12. [A8MVX0-2]
DR GeneID; 100271715; -.
DR KEGG; hsa:100271715; -.
DR MANE-Select; ENST00000409978.7; ENSP00000387020.1; NM_001145451.5; NP_001138923.2. [A8MVX0-2]
DR UCSC; uc021vgd.2; human. [A8MVX0-1]
DR CTD; 100271715; -.
DR DisGeNET; 100271715; -.
DR GeneCards; ARHGEF33; -.
DR HGNC; HGNC:37252; ARHGEF33.
DR HPA; ENSG00000214694; Tissue enriched (brain).
DR neXtProt; NX_A8MVX0; -.
DR VEuPathDB; HostDB:ENSG00000214694; -.
DR eggNOG; ENOG502RVY2; Eukaryota.
DR GeneTree; ENSGT00940000162759; -.
DR HOGENOM; CLU_018772_0_0_1; -.
DR InParanoid; A8MVX0; -.
DR OMA; LEHANMV; -.
DR OrthoDB; 229670at2759; -.
DR PhylomeDB; A8MVX0; -.
DR PathwayCommons; A8MVX0; -.
DR Reactome; R-HSA-193648; NRAGE signals death through JNK.
DR Reactome; R-HSA-416482; G alpha (12/13) signalling events.
DR BioGRID-ORCS; 100271715; 22 hits in 1064 CRISPR screens.
DR ChiTaRS; ARHGEF33; human.
DR GenomeRNAi; 100271715; -.
DR Pharos; A8MVX0; Tdark.
DR PRO; PR:A8MVX0; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; A8MVX0; protein.
DR Bgee; ENSG00000214694; Expressed in right hemisphere of cerebellum and 97 other tissues.
DR ExpressionAtlas; A8MVX0; baseline and differential.
DR GO; GO:0110165; C:cellular anatomical entity; IEA:UniProt.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.900.10; -; 1.
DR InterPro; IPR042849; ARHGEF33.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR PANTHER; PTHR46944; PTHR46944; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; SSF48065; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Guanine-nucleotide releasing factor;
KW Methylation; Reference proteome.
FT CHAIN 1..844
FT /note="Rho guanine nucleotide exchange factor 33"
FT /id="PRO_0000342343"
FT DOMAIN 265..440
FT /note="DH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 498..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 668..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 54..129
FT /evidence="ECO:0000255"
FT COMPBIAS 103..128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..803
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 757
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q8BW86"
FT VAR_SEQ 829..844
FT /note="NGNATGEDFCGPWGWW -> SSGSEYREKTNENPSMDPSPTKQDFFRNRLAL
FT ANDLDQGTAV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044905"
SQ SEQUENCE 844 AA; 94633 MW; 790FB919145D5C3E CRC64;
MEKTKTKQGE NEHMPVNNPS TQIYQLQALA SELKTGFTEA MQELSRIQHG EYALEEKVKS
CRCSMEEKVT EMKNSLNYFK EELSNAMSMI QAITSKQEEM QQKIEQLQQE KRRESRKVKA
KKTQKEEHSS QAGPAQAQGS PFRSINIPEP VLPSEDFTNL LPSQAYEKAQ ESRSVHVGDS
NVKGMMGPGV NPTTPEAEEN LKSCLSADIQ SKGHLPSGMW RQPKDGKEWG EEYVTKDHPD
KLKEAGQGRH SSLENVLCET SLAAKRQTVA LELLESERKY VINISLILKI KATFQGSDGK
RNSKERSLFP GSLRYLVQQH LDLLHALQER VLKWPRQGVL GDLFLKLTND ENNFLDYYVA
YLRDLPECIS LVHVVVLKEG DEEIKSDIYT LFFHIVQRIP EYLIHLQNVL KFTEQEHPDY
YLLLVCVQRL RVFISHYTLL FQCNEDLLIQ KRKKLKKSSM AKLYKGLASQ CANAGQDASP
TAGPEAVRDT GIHSEELLQP YPSAPSSGPA ITHLMPPVKK SQQQQSLMES MQPGKPSDWE
LEGRKHERPE SLLAPTQFCA AEQDVKALAG PLQAIPEMDF ESSPAEPLGN VERSLRAPAE
LLPDARGFVP AAYEEFEYGG EIFALPAPYD EEPFQAPALF ENCSPASSES SLDICFLRPV
SFAMEAERPE HPLQPLPKSA TSPAGSSSAY KLEAAAQAHG KAKPLSRSLK EFPRAPPADG
VAPRLYSTRS SSGGRAPIKA ERAAQAHGPA AAAVAARGAS RTFFPQQRSQ SEKQTYLEVR
REMHLEDTTR FCPKEERESE QTSFSDQNPR QDQKGGFRSS FRKLFKKKNG NATGEDFCGP
WGWW
