ID   ARFU_ARATH              Reviewed;         606 AA.
AC   Q9C8N9; Q9LNK2;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2004, sequence version 2.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Putative auxin response factor 21;
GN   Name=ARF21; OrderedLocusNames=At1g34410; ORFNames=F12K21.26, F7P12.12;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, NOMENCLATURE, AND FUNCTION.
RX   PubMed=12036261; DOI=10.1023/a:1015207114117;
RA   Hagen G., Guilfoyle T.J.;
RT   "Auxin-responsive gene expression: genes, promoters and regulatory
RT   factors.";
RL   Plant Mol. Biol. 49:373-385(2002).
RN   [4]
RP   GENE FAMILY.
RX   PubMed=18986826; DOI=10.1016/j.tplants.2008.09.006;
RA   Swaminathan K., Peterson K., Jack T.;
RT   "The plant B3 superfamily.";
RL   Trends Plant Sci. 13:647-655(2008).
CC   -!- FUNCTION: Auxin response factors (ARFs) are transcriptional factors
CC       that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the
CC       auxin-responsive promoter elements (AuxREs). Could act as
CC       transcriptional activator or repressor. Formation of heterodimers with
CC       Aux/IAA proteins may alter their ability to modulate early auxin
CC       response genes expression. {ECO:0000269|PubMed:12036261}.
CC   -!- SUBUNIT: Homodimers and heterodimers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DOMAIN: Interactions between auxin response factors (ARFs) and Aux/IAA
CC       proteins occur through their C-terminal dimerization domains III and
CC       IV.
CC   -!- SIMILARITY: Belongs to the ARF family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF79263.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=AAG51897.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC023279; AAF79263.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AC023913; AAG51897.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE31710.1; -; Genomic_DNA.
DR   PIR; E86468; E86468.
DR   RefSeq; NP_174701.2; NM_103164.2.
DR   AlphaFoldDB; Q9C8N9; -.
DR   SMR; Q9C8N9; -.
DR   STRING; 3702.AT1G34410.1; -.
DR   PaxDb; Q9C8N9; -.
DR   PRIDE; Q9C8N9; -.
DR   EnsemblPlants; AT1G34410.1; AT1G34410.1; AT1G34410.
DR   GeneID; 840344; -.
DR   Gramene; AT1G34410.1; AT1G34410.1; AT1G34410.
DR   KEGG; ath:AT1G34410; -.
DR   Araport; AT1G34410; -.
DR   TAIR; locus:2009298; AT1G34410.
DR   eggNOG; ENOG502QTME; Eukaryota.
DR   HOGENOM; CLU_002626_4_4_1; -.
DR   OMA; YSFATTM; -.
DR   OrthoDB; 551703at2759; -.
DR   PhylomeDB; Q9C8N9; -.
DR   PRO; PR:Q9C8N9; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9C8N9; differential.
DR   Genevisible; Q9C8N9; AT.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR   GO; GO:0009734; P:auxin-activated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR   CDD; cd10017; B3_DNA; 1.
DR   Gene3D; 2.40.330.10; -; 1.
DR   InterPro; IPR010525; ARF_dom.
DR   InterPro; IPR044835; ARF_plant.
DR   InterPro; IPR033389; AUX/IAA_dom.
DR   InterPro; IPR003340; B3_DNA-bd.
DR   InterPro; IPR015300; DNA-bd_pseudobarrel_sf.
DR   InterPro; IPR000270; PB1_dom.
DR   PANTHER; PTHR31384; PTHR31384; 1.
DR   Pfam; PF02309; AUX_IAA; 1.
DR   Pfam; PF06507; Auxin_resp; 1.
DR   Pfam; PF02362; B3; 1.
DR   SMART; SM01019; B3; 1.
DR   SUPFAM; SSF101936; SSF101936; 1.
DR   PROSITE; PS50863; B3; 1.
DR   PROSITE; PS51745; PB1; 1.
PE   3: Inferred from homology;
KW   Auxin signaling pathway; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..606
FT                   /note="Putative auxin response factor 21"
FT                   /id="PRO_0000111525"
FT   DOMAIN          511..592
FT                   /note="PB1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01081"
FT   DNA_BIND        126..228
FT                   /note="TF-B3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00326"
SQ   SEQUENCE   606 AA;  68779 MW;  BFC741DA6EBEE632 CRC64;
     MESGNIVNAQ PKLSGIIDGS KSYMYEQLWK LCAGPLCDIP KLGENVYYFP QGNIELVQAS
     TREELNELQP ICDLPSKLQC RVIAIHLKVE NNSDEIYAEI TLMPDTTQVV IPTQSENRFR
     PLVNSFTKVL TASDTSAYGG FSVPKKHAIE CLPPLDMSQP LPAQEILAID LHDNQWRFRH
     NYRGTPQRHS LTTGWNEFIT SKKLVKGDVI VFVRGETGEL RVGIRRARHQ QGNIPSSIVS
     IDCMRHGVIA SAKHAFDNQC IFIVVYKPRS SQFIVSYDKF LDAVNNKFNV GSRFTMRFEG
     DDFSERRYFG TIIGVSDFSP HWKCSEWRSL EVQWDEFASF SRPNKVSPWE IEHLVPALNV
     PRSSLLKNKR LREVNEFGSS SSHLLPPILT QGQEIGQLSV ASPMNISLRY RDTTEAAMNP
     SRLLMSYPVQ PMPKLNYNNQ MVTQIEENIT TKAGTNFRLF GVTLDTPPMI KDPIKQIGSD
     ISKLTERKKF GQSQTLRSPI EIQSKQFSSS RTCTKVQMQG VTIGRAVDLS VLNGYDQLIL
     ELEKLFDIKG QLQTRNQWKI AFTDSDGYEM LVGDDPWPEF CKMVKKILIY SKEEVKNLKS
     SKSLSS