ID   LCRV_YERPE              Reviewed;         326 AA.
AC   P0C7U7; O68697; P0C556; P21206; Q9L9Q7; Q9L9Q8;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Virulence-associated V antigen;
DE   AltName: Full=Low calcium response locus protein V;
GN   Name=lcrV; Synonyms=icrV;
GN   OrderedLocusNames=YPCD1.31c, y5047, y0050, YP_pCD52;
OS   Yersinia pestis.
OG   Plasmid pCD1.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KIM5 / Biovar Mediaevalis;
RX   PubMed=2477361; DOI=10.1128/jb.171.10.5646-5653.1989;
RA   Price S.B., Leung K.Y., Barve S.S., Straley S.C.;
RT   "Molecular analysis of lcrGVH, the V antigen operon of Yersinia pestis.";
RL   J. Bacteriol. 171:5646-5653(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KIM5 / Biovar Mediaevalis;
RX   PubMed=9746557; DOI=10.1128/iai.66.10.4611-4623.1998;
RA   Perry R.D., Straley S.C., Fetherston J.D., Rose D.J., Gregor J.,
RA   Blattner F.R.;
RT   "DNA sequencing and analysis of the low-Ca2+-response plasmid pCD1 of
RT   Yersinia pestis KIM5.";
RL   Infect. Immun. 66:4611-4623(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KIM5 / Biovar Mediaevalis;
RX   PubMed=9748454; DOI=10.1128/jb.180.19.5192-5202.1998;
RA   Hu P., Elliott J., McCready P., Skowronski E., Garnes J., Kobayashi A.,
RA   Brubaker R.R., Garcia E.;
RT   "Structural organization of virulence-associated plasmids of Yersinia
RT   pestis.";
RL   J. Bacteriol. 180:5192-5202(1998).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- FUNCTION: Possibly involved in calcium regulation of YOP expression,
CC       which includes the export process.
CC   -!- SUBCELLULAR LOCATION: Secreted.
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DR   EMBL; M26405; AAA27641.1; -; Genomic_DNA.
DR   EMBL; AF074612; AAC69799.1; -; Genomic_DNA.
DR   EMBL; AF053946; AAC62574.1; -; Genomic_DNA.
DR   EMBL; AL117189; CAB54908.1; -; Genomic_DNA.
DR   EMBL; AE017043; AAS58571.1; -; Genomic_DNA.
DR   PIR; B33601; B33601.
DR   RefSeq; NP_395165.1; NC_003131.1.
DR   RefSeq; NP_857751.1; NC_004836.1.
DR   RefSeq; NP_857946.1; NC_004839.1.
DR   RefSeq; WP_002212981.1; NZ_WUCM01000070.1.
DR   PDB; 1R6F; X-ray; 2.17 A; A=24-326.
DR   PDB; 4JBU; X-ray; 1.65 A; A=28-322.
DR   PDBsum; 1R6F; -.
DR   PDBsum; 4JBU; -.
DR   AlphaFoldDB; P0C7U7; -.
DR   SMR; P0C7U7; -.
DR   IntAct; P0C7U7; 2.
DR   STRING; 214092.5832451; -.
DR   PRIDE; P0C7U7; -.
DR   EnsemblBacteria; AAS58571; AAS58571; YP_pCD52.
DR   KEGG; ype:YPCD1.31c; -.
DR   KEGG; ypm:YP_pCD52; -.
DR   PATRIC; fig|214092.21.peg.42; -.
DR   eggNOG; ENOG502ZVN5; Bacteria.
DR   HOGENOM; CLU_946166_0_0_6; -.
DR   OMA; EKMSQTT; -.
DR   EvolutionaryTrace; P0C7U7; -.
DR   PHI-base; PHI:7136; -.
DR   Proteomes; UP000000815; Plasmid pCD1.
DR   Proteomes; UP000001019; Plasmid pCD1.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR005413; LowCa_resp_V_Ag.
DR   InterPro; IPR036139; Vir_assoc_V_ag_sf.
DR   Pfam; PF04792; LcrV; 1.
DR   PRINTS; PR01592; LCRVANTIGEN.
DR   SUPFAM; SSF103388; SSF103388; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Plasmid; Reference proteome; Secreted; Virulence.
FT   CHAIN           1..326
FT                   /note="Virulence-associated V antigen"
FT                   /id="PRO_0000084380"
FT   VARIANT         324..326
FT                   /note="SGK -> R (in strain: 91001)"
FT   HELIX           31..41
FT                   /evidence="ECO:0007829|PDB:4JBU"
FT   STRAND          45..48
FT                   /evidence="ECO:0007829|PDB:4JBU"
FT   TURN            52..54
FT                   /evidence="ECO:0007829|PDB:4JBU"
FT   HELIX           64..66
FT                   /evidence="ECO:0007829|PDB:4JBU"
FT   HELIX           68..78
FT                   /evidence="ECO:0007829|PDB:4JBU"
FT   HELIX           81..85
FT                   /evidence="ECO:0007829|PDB:4JBU"
FT   HELIX           92..107
FT                   /evidence="ECO:0007829|PDB:4JBU"
FT   STRAND          112..114
FT                   /evidence="ECO:0007829|PDB:4JBU"
FT   HELIX           115..126
FT                   /evidence="ECO:0007829|PDB:4JBU"
FT   HELIX           133..144
FT                   /evidence="ECO:0007829|PDB:4JBU"
FT   HELIX           149..179
FT                   /evidence="ECO:0007829|PDB:4JBU"
FT   STRAND          183..185
FT                   /evidence="ECO:0007829|PDB:4JBU"
FT   HELIX           196..199
FT                   /evidence="ECO:0007829|PDB:4JBU"
FT   HELIX           204..208
FT                   /evidence="ECO:0007829|PDB:4JBU"
FT   HELIX           211..216
FT                   /evidence="ECO:0007829|PDB:4JBU"
FT   STRAND          222..226
FT                   /evidence="ECO:0007829|PDB:4JBU"
FT   STRAND          229..233
FT                   /evidence="ECO:0007829|PDB:4JBU"
FT   HELIX           236..240
FT                   /evidence="ECO:0007829|PDB:4JBU"
FT   STRAND          243..245
FT                   /evidence="ECO:0007829|PDB:4JBU"
FT   STRAND          255..258
FT                   /evidence="ECO:0007829|PDB:4JBU"
FT   HELIX           281..318
FT                   /evidence="ECO:0007829|PDB:4JBU"
SQ   SEQUENCE   326 AA;  37240 MW;  8561A9A0C1A2E169 CRC64;
     MIRAYEQNPQ HFIEDLEKVR VEQLTGHGSS VLEELVQLVK DKNIDISIKY DPRKDSEVFA
     NRVITDDIEL LKKILAYFLP EDAILKGGHY DNQLQNGIKR VKEFLESSPN TQWELRAFMA
     VMHFSLTADR IDDDILKVIV DSMNHHGDAR SKLREELAEL TAELKIYSVI QAEINKHLSS
     SGTINIHDKS INLMDKNLYG YTDEEIFKAS AEYKILEKMP QTTIQVDGSE KKIVSIKDFL
     GSENKRTGAL GNLKNSYSYN KDNNELSHFA TTCSDKSRPL NDLVSQKTTQ LSDITSRFNS
     AIEALNRFIQ KYDSVMQRLL DDTSGK