ID   KUP_CUTAK               Reviewed;         651 AA.
AC   Q6A5S0;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Probable potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=PPA2187;
OS   Cutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium
OS   acnes).
OC   Bacteria; Actinobacteria; Propionibacteriales; Propionibacteriaceae;
OC   Cutibacterium.
OX   NCBI_TaxID=267747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16379 / KPA171202;
RX   PubMed=15286373; DOI=10.1126/science.1100330;
RA   Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A.,
RA   Strittmatter A., Hujer S., Duerre P., Gottschalk G.;
RT   "The complete genome sequence of Propionibacterium acnes, a commensal of
RT   human skin.";
RL   Science 305:671-673(2004).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01522};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE017283; AAT83893.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6A5S0; -.
DR   STRING; 267747.PPA2187; -.
DR   EnsemblBacteria; AAT83893; AAT83893; PPA2187.
DR   KEGG; pac:PPA2187; -.
DR   eggNOG; COG3158; Bacteria.
DR   HOGENOM; CLU_008142_4_2_11; -.
DR   OMA; AADQFEI; -.
DR   Proteomes; UP000000603; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..651
FT                   /note="Probable potassium transport system protein kup"
FT                   /id="PRO_0000209039"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        233..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        310..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        358..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        413..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        437..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   651 AA;  71177 MW;  A1B497EE6A70B43A CRC64;
     MIRSHERQAV AKATQPIVDR EPIRSMKPGL ALAALGIVFG DIGTSVLYSL QTVFSMENHA
     VRPTHGDVMG IISMIFWSIL LVVCVKYVIF VMRADNDGEG GILALMALVR RLMASHKGTG
     MTALLLGIVG AGLFYGDSFI TPAISVMSAV EGLTVANPDA EKIVLPASVV ILTLLFIVQR
     RGTEVIGKAF GPVMATWFLT LAALGIPWII HHPVIITALS PHWAILFSIE RPAMAFIAMG
     AVVLTITGAE ALYADMGHVG APSIRLAWFG LVLPCLLINY LGQGAMILSH PDWIDNPFFR
     MAPDWATIPL VTIATMATVI ASQAVISGAF SMSSEAARLG LLPRLGVRHT SKSEGGQIYI
     PEVNWTLFIG VLALILIFQT SSKLATAYGL AVTGTFLLTT SLFLVLAHRA WHWPMWALIF
     FGVIVGGVEL SIFSANLLKI ASGGWIPLLF ATIVVIIMTT WRRGTAYIAK QRQDDEGPLD
     DFLNWMHETK PTRVPGLAVY PHPGRATTPL ALLNNLRFNH VLHEHNIIIS IVVENVPHVR
     HVNRIEKVDL GRPTDGITYI ACHVGFTDSQ DVPKALALAA AKCPWLKDHL DEAIYYLSLV
     DVKRDEPQQG AHMAGWRKML YITMSRNQAD RTRVFRIPRT RAVVMGEAVA L