ID   KTHY_MYCPN              Reviewed;         210 AA.
AC   P75106;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Thymidylate kinase;
DE            EC=2.7.4.9;
DE   AltName: Full=dTMP kinase;
GN   Name=tmk; OrderedLocusNames=MPN_006; ORFNames=MP148;
OS   Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS   pneumoniae).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272634;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129;
RX   PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA   Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT   "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT   pneumoniae.";
RL   Nucleic Acids Res. 24:4420-4449(1996).
CC   -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
CC       salvage pathways of dTTP synthesis. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC         ChEBI:CHEBI:456216; EC=2.7.4.9;
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family. {ECO:0000305}.
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DR   EMBL; U00089; AAB95796.1; -; Genomic_DNA.
DR   PIR; S73474; S73474.
DR   RefSeq; NP_109694.1; NC_000912.1.
DR   RefSeq; WP_010874363.1; NC_000912.1.
DR   AlphaFoldDB; P75106; -.
DR   SMR; P75106; -.
DR   IntAct; P75106; 4.
DR   STRING; 272634.MPN_006; -.
DR   EnsemblBacteria; AAB95796; AAB95796; MPN_006.
DR   GeneID; 66609355; -.
DR   KEGG; mpn:MPN_006; -.
DR   PATRIC; fig|272634.6.peg.6; -.
DR   HOGENOM; CLU_049131_0_2_14; -.
DR   OMA; VMTREPG; -.
DR   BioCyc; MPNE272634:G1GJ3-9-MON; -.
DR   Proteomes; UP000000808; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00165; Thymidylate_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039430; Thymidylate_kin-like_dom.
DR   InterPro; IPR018095; Thymidylate_kin_CS.
DR   InterPro; IPR018094; Thymidylate_kinase.
DR   Pfam; PF02223; Thymidylate_kin; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00041; DTMP_kinase; 1.
DR   PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide biosynthesis; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..210
FT                   /note="Thymidylate kinase"
FT                   /id="PRO_0000155307"
FT   BINDING         11..18
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   210 AA;  23711 MW;  911F50922BA06FB0 CRC64;
     MKQGVFVAIE GVDGAGKTVL LEAFKQRFPQ SFLGFKTLFS REPGGTPLAE KIRALLLHEA
     MEPLTEAYLF AASRTEHVRQ LIQPALQQKQ LVIVDRFVWS SYAYQGLIKK VGLDVVKKLN
     ADAVGDSMPD FTFIVDCDFE TALNRMAKRG QDNLLDNTVK KQADFNTMRQ YYHSLVDNKR
     VFLLDGQNQT GCLEQFIEQL SQCLTQPTLS