ID   KIZ_XENLA               Reviewed;         736 AA.
AC   A1L2H3;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 2.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=Centrosomal protein kizuna;
DE   AltName: Full=Polo-like kinase 1 substrate 1;
GN   Name=kiz; Synonyms=plk1s1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Centrosomal protein required for establishing a robust
CC       mitotic centrosome architecture that can endure the forces that
CC       converge on the centrosomes during spindle formation. Required for
CC       stabilizing the expanded pericentriolar material around the centriole.
CC       {ECO:0000250|UniProtKB:Q2M2Z5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250|UniProtKB:Q2M2Z5}. Cytoplasm,
CC       cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q2M2Z5}.
CC   -!- SIMILARITY: Belongs to the kizuna family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI29528.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC129527; AAI29528.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; A1L2H3; -.
DR   SMR; A1L2H3; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0007051; P:spindle organization; ISS:UniProtKB.
DR   InterPro; IPR026742; Centrosomal_kizuma.
DR   PANTHER; PTHR16299; PTHR16299; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..736
FT                   /note="Centrosomal protein kizuna"
FT                   /id="PRO_0000381816"
FT   REGION          192..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          279..305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          323..348
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          642..690
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          10..35
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        192..212
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..228
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        279..304
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        646..667
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   736 AA;  82673 MW;  76E87C5EDF9970DF CRC64;
     MAEGNSDYDH RAMKLQRNLR HCEGKRLELE RELFQHSSSD AHICHLKYMK LKNSLKEVCE
     RGKKAHLRNQ AFLQEFDLIE ARLFGLISNA NALQKKKMQL KSHPPEMNKG PNMSRSTYHP
     ATIFMGRQMS ASSSIEHCLT QRKSPQPTKS FSISDPHSVR QAAMNRNVTD SCVVPANSDI
     QCLNKPDKID GNTSFQLSQK MPVTSVASSE DGRTHRAQID KSQSGRKHLV ESKQSAQLST
     QILERLSPEN RARDLQNDSP GNMVEKSLMY ERLVPNEESF THANPSGASP DACDYINNQT
     SDKHSARENL SETIESHLIP EEEDKQCLDS SSDLTVSISE SEDDSYPPCE VNRIEVNQND
     EKNLYTALPK QETVILKNYE QSSVIQPLQT SEVNSCDESS SASTISQSNL SDEGFFHLLQ
     SIERMVLLRE QGGMELYQRA GINQKQLLRL ISVCNRMGAL RVEDLEACCA LVLCKTQELL
     KSTFVGYSHE ATAGIHNTDE SKERFLSRKC QERLLGHIAF LNKHHILNEK VLPECFTSVM
     MLSDGQNSCK SVENVENSTE DGNVPQVSST MKDDPLTIKP RQIVQELYKT TGSSHQEFET
     QVHPGVVLQS ANISVESNTQ AEEENDEDEI SDLSEIYIPG LTVEEGNATT KASKKQISET
     SFSSSEKSPI SRKEDKNIQP NYMKSNNMST GNKFSKVVTT VKSKAFWGES EDSSSEIEAM
     LRPKTESVDD FDDFFD