ID   KAL_ACESD               Reviewed;         126 AA.
AC   E3PRK1;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=3-aminobutyryl-CoA ammonia lyase {ECO:0000250|UniProtKB:Q8RHX1};
DE            EC=4.3.1.14 {ECO:0000250|UniProtKB:Q8RHX1};
DE   AltName: Full=3-aminobutyryl-CoA deaminase {ECO:0000250|UniProtKB:Q8RHX1};
GN   Name=kal {ECO:0000250|UniProtKB:Q8RHX1}; OrderedLocusNames=CLOST_1385;
OS   Acetoanaerobium sticklandii (strain ATCC 12662 / DSM 519 / JCM 1433 / CCUG
OS   9281 / NCIMB 10654 / HF) (Clostridium sticklandii).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC   Acetoanaerobium.
OX   NCBI_TaxID=499177;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12662 / DSM 519 / JCM 1433 / CCUG 9281 / NCIMB 10654 / HF
RC   {ECO:0000269|PubMed:20937090};
RX   PubMed=20937090; DOI=10.1186/1471-2164-11-555;
RA   Fonknechten N., Chaussonnerie S., Tricot S., Lajus A., Andreesen J.R.,
RA   Perchat N., Pelletier E., Gouyvenoux M., Barbe V., Salanoubat M.,
RA   Le Paslier D., Weissenbach J., Cohen G.N., Kreimeyer A.;
RT   "Clostridium sticklandii, a specialist in amino acid degradation:revisiting
RT   its metabolism through its genome sequence.";
RL   BMC Genomics 11:555-555(2010).
CC   -!- FUNCTION: Involved in the anaerobic fermentation of lysine. Catalyzes
CC       the deamination of L-3-aminobutyryl-CoA to produce crotonoyl-CoA.
CC       {ECO:0000250|UniProtKB:Q8RHX1}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(3S)-3-aminobutanoyl-CoA = (2E)-butenoyl-CoA + NH4(+);
CC         Xref=Rhea:RHEA:10056, ChEBI:CHEBI:28938, ChEBI:CHEBI:57332,
CC         ChEBI:CHEBI:57366; EC=4.3.1.14;
CC         Evidence={ECO:0000250|UniProtKB:Q8RHX1};
CC   -!- PATHWAY: Amino-acid degradation; L-lysine degradation via acetate
CC       pathway. {ECO:0000250|UniProtKB:Q8RHX1}.
CC   -!- SUBUNIT: Homohexamer. {ECO:0000250|UniProtKB:Q8RHX1}.
CC   -!- SIMILARITY: Belongs to the KAL family. {ECO:0000305}.
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DR   EMBL; FP565809; CBH21505.1; -; Genomic_DNA.
DR   AlphaFoldDB; E3PRK1; -.
DR   SMR; E3PRK1; -.
DR   STRING; 1511.CLOST_1385; -.
DR   EnsemblBacteria; CBH21505; CBH21505; CLOST_1385.
DR   KEGG; cst:CLOST_1385; -.
DR   eggNOG; COG1607; Bacteria.
DR   HOGENOM; CLU_149200_0_0_9; -.
DR   OMA; YAGDYIE; -.
DR   UniPathway; UPA00870; -.
DR   Proteomes; UP000007041; Chromosome.
DR   GO; GO:0047459; F:3-aminobutyryl-CoA ammonia-lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019475; P:L-lysine catabolic process to acetate; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   InterPro; IPR006683; Thioestr_dom.
DR   Pfam; PF03061; 4HBT; 1.
DR   SUPFAM; SSF54637; SSF54637; 1.
PE   3: Inferred from homology;
KW   Lyase; Reference proteome.
FT   CHAIN           1..126
FT                   /note="3-aminobutyryl-CoA ammonia lyase"
FT                   /id="PRO_0000416978"
SQ   SEQUENCE   126 AA;  13845 MW;  877ECFDE414D3076 CRC64;
     MKSVLKIRMS AHDAHYGGGL VDGARMLQLF GDVATELLIM NDGDEGLFKA YDMVEFMAPV
     FAGDYIEVEG SITEQGNTSR KMIFEARKVI VPRTDINDSA CDVLETPIVV CRASGTCVVP
     KDKQRK