ID   KAIA_PARMW              Reviewed;         296 AA.
AC   Q7U8R5;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Circadian clock protein KaiA;
GN   Name=kaiA; OrderedLocusNames=SYNW0548;
OS   Parasynechococcus marenigrum (strain WH8102).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Parasynechococcus; Parasynechococcus marenigrum.
OX   NCBI_TaxID=84588;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WH8102;
RX   PubMed=12917641; DOI=10.1038/nature01943;
RA   Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L., Chain P.,
RA   Lamerdin J.E., Regala W., Allen E.E., McCarren J., Paulsen I.T.,
RA   Dufresne A., Partensky F., Webb E.A., Waterbury J.;
RT   "The genome of a motile marine Synechococcus.";
RL   Nature 424:1037-1042(2003).
CC   -!- FUNCTION: Component of the KaiABC clock protein complex, which
CC       constitutes the main circadian regulator in cyanobacteria. The KaiABC
CC       complex may act as a promoter-nonspecific transcription regulator that
CC       represses transcription, possibly by acting on the state of chromosome
CC       compaction. In the complex, it enhances the phosphorylation status of
CC       KaiC. In contrast, the presence of KaiB in the complex decreases the
CC       phosphorylation status of KaiC, suggesting that KaiB acts by
CC       antagonizing the interaction between KaiA and KaiC. A KaiA dimer is
CC       sufficient to enhance KaiC hexamer phosphorylation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Component of the KaiABC complex, at least composed
CC       of a KaiC homohexamer, a KaiB dimer and two KaiA dimers. The KaiABC
CC       complex also interacts with SasA (By similarity). {ECO:0000250}.
CC   -!- DOMAIN: The KaiA domain mediates the interaction with KaiC, the
CC       homodimerization, and is responsible for the clock oscillation
CC       function. {ECO:0000250}.
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DR   EMBL; BX569690; CAE07063.1; -; Genomic_DNA.
DR   RefSeq; WP_011127417.1; NC_005070.1.
DR   AlphaFoldDB; Q7U8R5; -.
DR   SMR; Q7U8R5; -.
DR   STRING; 84588.SYNW0548; -.
DR   EnsemblBacteria; CAE07063; CAE07063; SYNW0548.
DR   KEGG; syw:SYNW0548; -.
DR   eggNOG; ENOG502Z8HQ; Bacteria.
DR   HOGENOM; CLU_911234_0_0_3; -.
DR   OMA; VMAHLCE; -.
DR   OrthoDB; 1326064at2; -.
DR   Proteomes; UP000001422; Chromosome.
DR   GO; GO:0007623; P:circadian rhythm; IEA:InterPro.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   Gene3D; 1.10.1240.30; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR011648; Circadian_clock_KaiA.
DR   InterPro; IPR020844; Circadian_clock_KaiA_N.
DR   InterPro; IPR020856; Circadian_clock_protein_KaiA_C.
DR   InterPro; IPR017944; KaiA/RbsU_helical_domain_sf.
DR   Pfam; PF07688; KaiA; 1.
DR   SMART; SM01247; KaiA; 1.
DR   SUPFAM; SSF101215; SSF101215; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51431; KAIA_C; 1.
DR   PROSITE; PS51430; KAIA_N; 1.
PE   3: Inferred from homology;
KW   Biological rhythms.
FT   CHAIN           1..296
FT                   /note="Circadian clock protein KaiA"
FT                   /id="PRO_0000217872"
FT   DOMAIN          2..152
FT                   /note="KaiA N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00760"
FT   DOMAIN          162..270
FT                   /note="KaiA C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00761"
SQ   SEQUENCE   296 AA;  33387 MW;  89EBBE0D977568B3 CRC64;
     MARPGLTIAL LLTTPNLVDA CQQWLPDTRY HSIVLSGPHQ GQEQLDLVST LEAQQEEIDA
     VVVEQQLLDA SSRDQLLGRG LLFPAVVVGE MKGHVDYHAE ELHLAEDQLA QLGYTVDAAI
     SRFLRQGRAD GRSDDDGLAS VDKLSRRLQE RLGYLGVFYK RDPSRFLGSL PTEERRELLE
     SLQRTYRDLL ISYFSDPAAS NQALESFVNT AFFSDLPITR TVDIHVDQID EFWKQLRLEG
     NKSEFLQDYR LALLDVMAHL CEMYRRSIPP DIPLSGLASG RHRREADLPD APEVSS