ID   KAIA_ACAM1              Reviewed;         299 AA.
AC   Q6L8L3; B0C0R2;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Circadian clock protein KaiA;
GN   Name=kaiA; OrderedLocusNames=AM1_0994;
OS   Acaryochloris marina (strain MBIC 11017).
OC   Bacteria; Cyanobacteria; Synechococcales; Acaryochloridaceae;
OC   Acaryochloris.
OX   NCBI_TaxID=329726;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MBIC 11017;
RX   PubMed=18252824; DOI=10.1073/pnas.0709772105;
RA   Swingley W.D., Chen M., Cheung P.C., Conrad A.L., Dejesa L.C., Hao J.,
RA   Honchak B.M., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D.,
RA   Miyashita H., Page L., Ramakrishna P., Satoh S., Sattley W.M., Shimada Y.,
RA   Taylor H.L., Tomo T., Tsuchiya T., Wang Z.T., Raymond J., Mimuro M.,
RA   Blankenship R.E., Touchman J.W.;
RT   "Niche adaptation and genome expansion in the chlorophyll d-producing
RT   cyanobacterium Acaryochloris marina.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:2005-2010(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 85-298.
RX   PubMed=15170179; DOI=10.1038/nsmb781;
RA   Uzumaki T., Fujita M., Nakatsu T., Hayashi F., Shibata H., Itoh N.,
RA   Kato H., Ishiura M.;
RT   "Crystal structure of the C-terminal clock-oscillator domain of the
RT   cyanobacterial KaiA protein.";
RL   Nat. Struct. Mol. Biol. 11:623-631(2004).
CC   -!- FUNCTION: Component of the KaiABC clock protein complex, which
CC       constitutes the main circadian regulator in cyanobacteria. The KaiABC
CC       complex may act as a promoter-nonspecific transcription regulator that
CC       represses transcription, possibly by acting on the state of chromosome
CC       compaction. In the complex, it enhances the phosphorylation status of
CC       KaiC. In contrast, the presence of KaiB in the complex decreases the
CC       phosphorylation status of KaiC, suggesting that KaiB acts by
CC       antagonizing the interaction between KaiA and KaiC. A KaiA dimer is
CC       sufficient to enhance KaiC hexamer phosphorylation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Component of the KaiABC complex, at least composed
CC       of a KaiC homohexamer, a KaiB dimer and two KaiA dimers. The KaiABC
CC       complex also interacts with SasA (By similarity). {ECO:0000250}.
CC   -!- DOMAIN: The KaiA domain mediates the interaction with KaiC, the
CC       homodimerization, and is responsible for the clock oscillation
CC       function. {ECO:0000250}.
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DR   EMBL; CP000828; ABW26036.1; -; Genomic_DNA.
DR   EMBL; AB120712; BAD21215.1; -; Genomic_DNA.
DR   RefSeq; WP_012161597.1; NC_009925.1.
DR   AlphaFoldDB; Q6L8L3; -.
DR   SMR; Q6L8L3; -.
DR   STRING; 329726.AM1_0994; -.
DR   EnsemblBacteria; ABW26036; ABW26036; AM1_0994.
DR   KEGG; amr:AM1_0994; -.
DR   eggNOG; ENOG502Z8HQ; Bacteria.
DR   HOGENOM; CLU_911234_0_0_3; -.
DR   OMA; VMAHLCE; -.
DR   OrthoDB; 1326064at2; -.
DR   Proteomes; UP000000268; Chromosome.
DR   GO; GO:0007623; P:circadian rhythm; IEA:InterPro.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   Gene3D; 1.10.1240.30; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR011648; Circadian_clock_KaiA.
DR   InterPro; IPR020844; Circadian_clock_KaiA_N.
DR   InterPro; IPR020856; Circadian_clock_protein_KaiA_C.
DR   InterPro; IPR017944; KaiA/RbsU_helical_domain_sf.
DR   Pfam; PF07688; KaiA; 1.
DR   SMART; SM01247; KaiA; 1.
DR   SUPFAM; SSF101215; SSF101215; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51431; KAIA_C; 1.
DR   PROSITE; PS51430; KAIA_N; 1.
PE   3: Inferred from homology;
KW   Biological rhythms; Reference proteome.
FT   CHAIN           1..299
FT                   /note="Circadian clock protein KaiA"
FT                   /id="PRO_0000217867"
FT   DOMAIN          9..179
FT                   /note="KaiA N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00760"
FT   DOMAIN          189..297
FT                   /note="KaiA C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00761"
SQ   SEQUENCE   299 AA;  34921 MW;  6D2B3DEED6C918CA CRC64;
     MTLSQTAVSR PQIFICTLLS SESLVDLYTQ ILEGDRYSLV HATYDNFLEI VEQGKHRIDC
     LIFEKNAALP KVVSHLHREA ILLPAVLLQV EESVEKTSQP NSADRDPQQD SYYHIAEVIV
     DHDQEDILSS IDCAIAQFLQ LSKACRLPTR LQKKYADEAI QDNLATQQQR LSQKLKERLG
     YLGVYYKRNP QQFFHKLTEE EQTDYLVTLK RDYRDIILNY FRQDSSVNQE IDDFVTQIFF
     ADISILKILE IHMELMDAFA KKLKLEGRNE DILLDYRLTL IDIMAHLCEM YRRSIPKTR