ID   JZT58_CHIGU             Reviewed;          94 AA.
AC   B1P1H8;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=U27-theraphotoxin-Cg1a;
DE            Short=U27-TRTX-Cg1a;
DE   AltName: Full=Jingzhaotoxin-58;
DE            Short=JZTX-58;
DE   Flags: Precursor;
OS   Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys
OS   jingzhao).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Chilobrachys.
OX   NCBI_TaxID=278060;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=18581053; DOI=10.1007/s00018-008-8135-x;
RA   Chen J., Deng M., He Q., Meng E., Jiang L., Liao Z., Rong M., Liang S.;
RT   "Molecular diversity and evolution of cystine knot toxins of the tarantula
RT   Chilobrachys jingzhao.";
RL   Cell. Mol. Life Sci. 65:2431-2444(2008).
CC   -!- FUNCTION: Probable ion channel inhibitor.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 14 (magi-1) family. OAIP-1
CC       subfamily.
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DR   EMBL; EU233909; ABY71728.1; -; mRNA.
DR   AlphaFoldDB; B1P1H8; -.
DR   SMR; B1P1H8; -.
DR   ArachnoServer; AS000857; U27-theraphotoxin-Cg1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Ion channel impairing toxin; Knottin; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..58
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000398530"
FT   PEPTIDE         59..94
FT                   /note="U27-theraphotoxin-Cg1a"
FT                   /id="PRO_0000398531"
FT   DISULFID        60..78
FT                   /evidence="ECO:0000250"
FT   DISULFID        67..83
FT                   /evidence="ECO:0000250"
FT   DISULFID        77..88
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   94 AA;  10628 MW;  2A21F6A01CF1CE6C CRC64;
     MIFLLPPVIF VMLLAESVLI LGDSEDADLM EMVQMSRPFF NPIIPAVEFV DLREERQRAC
     GHLHDPCPND RPGHRTCCIG LQCRYGSCLV QVGR