ID   ISN1_SCHPO              Reviewed;         405 AA.
AC   O14349;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=IMP-specific 5'-nucleotidase 1;
DE            EC=3.1.3.99 {ECO:0000250|UniProtKB:Q99312};
GN   Name=isn1; ORFNames=SPBC30D10.03c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: IMP-specific 5'-nucleotidase involved in IMP (inositol
CC       monophosphate) degradation. {ECO:0000250|UniProtKB:Q99312}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + IMP = inosine + phosphate; Xref=Rhea:RHEA:27718,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:17596, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:58053; EC=3.1.3.99;
CC         Evidence={ECO:0000250|UniProtKB:Q99312};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000250|UniProtKB:Q99312};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250|UniProtKB:Q99312}.
CC   -!- SIMILARITY: Belongs to the ISN1 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAB10798.1; -; Genomic_DNA.
DR   PIR; T40193; T40193.
DR   RefSeq; NP_596282.1; NM_001022203.2.
DR   AlphaFoldDB; O14349; -.
DR   SMR; O14349; -.
DR   BioGRID; 276873; 11.
DR   STRING; 4896.SPBC30D10.03c.1; -.
DR   iPTMnet; O14349; -.
DR   SwissPalm; O14349; -.
DR   MaxQB; O14349; -.
DR   PaxDb; O14349; -.
DR   PRIDE; O14349; -.
DR   EnsemblFungi; SPBC30D10.03c.1; SPBC30D10.03c.1:pep; SPBC30D10.03c.
DR   GeneID; 2540344; -.
DR   KEGG; spo:SPBC30D10.03c; -.
DR   PomBase; SPBC30D10.03c; isn1.
DR   VEuPathDB; FungiDB:SPBC30D10.03c; -.
DR   eggNOG; ENOG502QR24; Eukaryota.
DR   HOGENOM; CLU_031816_1_0_1; -.
DR   InParanoid; O14349; -.
DR   OMA; FKARLAC; -.
DR   PhylomeDB; O14349; -.
DR   PRO; PR:O14349; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0050483; F:IMP 5'-nucleotidase activity; ISO:PomBase.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0006190; P:inosine salvage; ISO:PomBase.
DR   GO; GO:0071590; P:nicotinamide riboside biosynthetic process; IBA:GO_Central.
DR   GO; GO:0071592; P:nicotinic acid riboside biosynthetic process; IBA:GO_Central.
DR   GO; GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR009453; ISN1.
DR   PANTHER; PTHR28213; PTHR28213; 1.
DR   Pfam; PF06437; ISN1; 1.
DR   PIRSF; PIRSF028836; ISN1; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Magnesium; Nucleotide metabolism; Reference proteome.
FT   CHAIN           1..405
FT                   /note="IMP-specific 5'-nucleotidase 1"
FT                   /id="PRO_0000084255"
SQ   SEQUENCE   405 AA;  45806 MW;  952F196D1E65C21D CRC64;
     MASRYRVEYA LKQHRKDDFI EWIKGLLSVP FVLQAGTPSQ KLVTREKEQE TLERYAVILR
     DVEKLIEAHI QIVSEGGSYS QLKMLVPSIT IFWTPLPLVK AMYALEPKLC LAKRSFVAPS
     FNDVRAILGG AQLNYLADNG LDMVSFDGDV TLYEDGQPLL PDNPVISRLI QLLSRGIYVI
     ILTAAGYPSR TGQEYTDRFS GLLQAIEDSD LKDGQKRKLH VLGGESNYLF AYDPLHGLQW
     VDADSWMLPV MKTWPHDEIL EILDTAEETL RSCIQGLNID AKIVRKERSV GFVPSLGQKL
     RREQLEEAVL ETQATLQIRN FSVPFTAFNG GNDIWCDIGD KKLGVLCLQH FFNISHPSRC
     LHVGDQFLSA GNNDYKARAA ATTVWVSSPH ETIEFLDYYF SFLKK