ID   ISN1_NEUCR              Reviewed;         431 AA.
AC   Q7SDZ1; A7UVZ0; Q27QA3; V5INY2;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-FEB-2014, sequence version 2.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=IMP-specific 5'-nucleotidase 1;
DE            EC=3.1.3.99 {ECO:0000250|UniProtKB:Q99312};
GN   Name=isn-1; ORFNames=NCU01945, NCU10480;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Adiopodoume-1 / FGSC 430;
RX   PubMed=17301493; DOI=10.1007/bf02708407;
RA   Tamuli R., Ravindran C., Kasbekar D.P.;
RT   "Translesion DNA polymerases Pol zeta, Pol eta, Pol iota, Pol kappa and
RT   Rev1 are not essential for repeat-induced point mutation in Neurospora
RT   crassa.";
RL   J. Biosci. 31:557-564(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: IMP-specific 5'-nucleotidase involved in IMP (inositol
CC       monophosphate) degradation. {ECO:0000250|UniProtKB:Q99312}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + IMP = inosine + phosphate; Xref=Rhea:RHEA:27718,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:17596, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:58053; EC=3.1.3.99;
CC         Evidence={ECO:0000250|UniProtKB:Q99312};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000250|UniProtKB:Q99312};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250|UniProtKB:Q99312}.
CC   -!- SIMILARITY: Belongs to the ISN1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABD57298.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; DQ387872; ABD57298.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CM002236; ESA43848.1; -; Genomic_DNA.
DR   RefSeq; XP_011392906.1; XM_011394604.1.
DR   AlphaFoldDB; Q7SDZ1; -.
DR   SMR; Q7SDZ1; -.
DR   STRING; 5141.EFNCRP00000001288; -.
DR   EnsemblFungi; ESA43848; ESA43848; NCU01945.
DR   GeneID; 23568370; -.
DR   KEGG; ncr:NCU01945; -.
DR   VEuPathDB; FungiDB:NCU01945; -.
DR   HOGENOM; CLU_031816_1_0_1; -.
DR   InParanoid; Q7SDZ1; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0050483; F:IMP 5'-nucleotidase activity; IBA:GO_Central.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0006190; P:inosine salvage; IBA:GO_Central.
DR   GO; GO:0071590; P:nicotinamide riboside biosynthetic process; IBA:GO_Central.
DR   GO; GO:0071592; P:nicotinic acid riboside biosynthetic process; IBA:GO_Central.
DR   GO; GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR009453; ISN1.
DR   PANTHER; PTHR28213; PTHR28213; 1.
DR   Pfam; PF06437; ISN1; 1.
DR   PIRSF; PIRSF028836; ISN1; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Magnesium; Nucleotide metabolism; Reference proteome.
FT   CHAIN           1..431
FT                   /note="IMP-specific 5'-nucleotidase 1"
FT                   /id="PRO_0000084254"
SQ   SEQUENCE   431 AA;  48444 MW;  F0CD380D72C1D867 CRC64;
     MTTRYRVEYA LKTHRRDQFI EWIKALLAVP FVLYSQPHGV LEDPDRSVDT LSQTREEAHR
     RYSEIFRDIE AMIDDHIAHQ NDAENPFPSK LKLLVPSIGP FFTRLPLEAA FKFQDNKRYI
     SSRRFVSPSF NDIRLILNSA QIMAVTTYGT LQLATFDGDV TLYDDGQSLE PTSPVIPRLL
     DLLRKNVKIG IVTAAGYTTA DRYYSRLHGL LDAMANSADL TPSQKQSLVV MGGEANYLFE
     FDSSSPHLLA PVPRQHWLTP EMAAWNEQDI AQLLDVAEAA LRDCIKTLNL PATLMRKDRA
     VGIIPVSPEI RIPRESLEET VLLVQKILEL STVGRSRRVP FCAFNGGRDV FVDIGDKSWG
     VTVCQRWFSQ KEGPHGVIKG ENTLHVGDQF LSAGANDFRA RSVGTTAWIA SPVETVELLD
     ELAELMGKKM S