ISN1_GIBZE
ID ISN1_GIBZE Reviewed; 446 AA.
AC Q4HTS9; A0A098DEH7; A0A0E0S1K3; A0A1C3YMF3; V6RJE7;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-SEP-2016, sequence version 2.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=IMP-specific 5'-nucleotidase 1;
DE EC=3.1.3.99 {ECO:0000250|UniProtKB:Q99312};
GN Name=ISN1; ORFNames=FGRAMPH1_01T11151, FGRRES_11629_M, FGSG_11629;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
CC -!- FUNCTION: IMP-specific 5'-nucleotidase involved in IMP (inositol
CC monophosphate) degradation. {ECO:0000250|UniProtKB:Q99312}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + IMP = inosine + phosphate; Xref=Rhea:RHEA:27718,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:17596, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:58053; EC=3.1.3.99;
CC Evidence={ECO:0000250|UniProtKB:Q99312};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000250|UniProtKB:Q99312};
CC -!- SUBUNIT: Homotetramer. {ECO:0000250|UniProtKB:Q99312}.
CC -!- SIMILARITY: Belongs to the ISN1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ESU14369.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS231667; ESU14369.1; ALT_SEQ; Genomic_DNA.
DR EMBL; HG970333; SCB65686.1; -; Genomic_DNA.
DR RefSeq; XP_011319794.1; XM_011321492.1.
DR AlphaFoldDB; Q4HTS9; -.
DR SMR; Q4HTS9; -.
DR STRING; 5518.FGSG_11629P0; -.
DR EnsemblFungi; ESU14369; ESU14369; FGSG_11629.
DR GeneID; 23558450; -.
DR KEGG; fgr:FGSG_11629; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G11151; -.
DR eggNOG; ENOG502QR24; Eukaryota.
DR HOGENOM; CLU_031816_1_0_1; -.
DR InParanoid; Q4HTS9; -.
DR Proteomes; UP000070720; Chromosome 2.
DR GO; GO:0050483; F:IMP 5'-nucleotidase activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0006190; P:inosine salvage; IEA:InterPro.
DR GO; GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR009453; ISN1.
DR PANTHER; PTHR28213; PTHR28213; 1.
DR Pfam; PF06437; ISN1; 1.
DR PIRSF; PIRSF028836; ISN1; 1.
DR SUPFAM; SSF56784; SSF56784; 1.
PE 3: Inferred from homology;
KW Hydrolase; Magnesium; Nucleotide metabolism; Reference proteome.
FT CHAIN 1..446
FT /note="IMP-specific 5'-nucleotidase 1"
FT /id="PRO_0000084252"
FT REGION 328..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 446 AA; 49756 MW; 9B82AB9C6641E50C CRC64;
MTTRYRVEYA LKTHRRDQFI EWVKGLLAVP FVLYSQPTGV FGDGPSVTQM AEEAHRRYAE
IMRDVELMID DHISRQQDDS MFPSKLRMLI PTAGPFFTRL PLEAAFKYQD RKRYISSRRF
VAPSFNDVRQ ILNSAQSMAV TNGSLQLATF DGDVTLYDDG FNLEPTSPVI PRLLDLLRKN
IKIGIVTAAG YTSADRYYER LHGLLDAIAE STDLDPVQKQ SIIIMGGEAN YLFEYSPSSP
CKLAPVPRTQ WLTPEMASWS DADITRLLDV AENALRDCVN NLNLPAMIMR KDRAVGIIPK
TPGTRIARES LEETVLVVQR ILELSSLGSS EERPTKHRPS SPPIPPSVAS QSRRVPFCAF
NGGNDVFVDI GDKSWGVTVC QQWFGSKENG GAIRGENTLH VGDQFLSAGS NDFKARSVGT
TAWIASPAET VELLDELADM MQKKLS
